2002
DOI: 10.1046/j.1432-1033.2002.03139.x
|View full text |Cite
|
Sign up to set email alerts
|

Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C‐terminally truncated gaegurin 4

Abstract: Gaegurin 4 (GGN4), a 37-residue antimicrobial peptide, consists of two amphipathic a helices (residues 2-10 and 16-32) connected by a flexible loop region (residues 11-15). As part of an effort to develop new peptide antibiotics with low molecular mass, the activities of C-terminally truncated GGN4 analogues were tested. D 24)37 GGN4, a peptide analogue with 14 residues truncated from the C-terminus of GGN4, showed a complete loss of antimicrobial activity. However, the single substitution of aspartic acid 16 … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

6
64
0

Year Published

2004
2004
2020
2020

Publication Types

Select...
5
1

Relationship

4
2

Authors

Journals

citations
Cited by 43 publications
(70 citation statements)
references
References 39 publications
6
64
0
Order By: Relevance
“…Three scans were added and averaged, followed by subtraction of the CD signal of the solvent. Finally, the CD intensity was normalized as the mean residue molar ellipticity (21)…”
Section: Methodsmentioning
confidence: 99%
See 4 more Smart Citations
“…Three scans were added and averaged, followed by subtraction of the CD signal of the solvent. Finally, the CD intensity was normalized as the mean residue molar ellipticity (21)…”
Section: Methodsmentioning
confidence: 99%
“…NATA was used as a control material for fluorescence experiments, as it is an indole derivative that closely mimics a tryptophan residue involved in peptide bonds (21,30,31). NMR Spectroscopy-Samples for NMR measurements contained 3 mM peptide in a 300 mM SDS-d 25 solution containing 7% D 2 O at pH 4.0.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations