Effects of a β-Adrenergic Agonist (Clenbuterol) on Growth and Muscle Composition in Broiler Chicks Treated with or without Thyroxine

美夫, 濱野; 周, 山崎; 至, 本間; 茂樹, 小林; 福秋, 寺島

doi:10.2508/chikusan.66.599

Cited by 2 publications

(3 citation statements)

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“…Furthermore, although this vitamin has been shown to be associated with insulin and thyroid hormones (Segermann et al 1991;Streeper et al 1997), whether there is an interrelationship with b-adrenergic response is unclear. With regard to repartitioning nutrients in chickens, the metabolic response to b-agonist supplementation, which stimulates protein deposition and decreases adipose tissue accretion (Dalrymple et al 1984;Weppelman, 1984;Buyse et al 1991), is dependent on nutritional and hormonal states (Hamano et al 1994(Hamano et al , 1995(Hamano et al , 1998. In addition, the b-adrenergic response of leanness in chickens is thought to be generally weaker than that of mammals (Yang & McElligott, 1989;Wellenreiter, 1991).…”

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Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

et al. 1999

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The present study was conducted to determine the role of α-lipoic acid (LA) in plasma metabolites, hepatic O2 consumption, and β-adrenergic response in broilers. In Expt 1, 12-d-old female broiler chicks were divided into three dietary groups and fed on diets with or without LA (5 or 50 mg/kg) until 4 or 6 weeks of age, as a 2 × 3 factorial arrangement. The dietary LA had no effect on growth rates (body weight, abdominal fat, breast muscle, and liver). The higher level of LA increased plasma non-esterified fatty acid and decreased plasma triacylglycerol concentrations only at 6 weeks of age. A 42 % increase in hepatic respiration was observed in the 4-week-old chickens given 50 mg LA/kg diet. In Expt 2, 3-d-old female broiler chicks were treated with or without dietary LA at 50 mg/kg. At 30 and 31 d old, isoproterenol (2 mg/kg body weight per h) was continuously infused into a wing vein for 2 h, and changes in plasma glucose, triacylglycerol, and non-esterified fatty acid concentrations were analysed. Isoproterenol increased plasma glucose over basal levels maximally at 60 min. Furthermore, the glucose increase in the LA-treated chickens was 35% greater than that of the controls at this time. Plasma non-esterified fatty acid and triacylglycerol concentrations were decreased by the isoproterenol infusion, regardless of LA administration. Therefore, the present study suggests that dietary LA has repartitioning effects on energy metabolism in chickens (although this depends on age-related metabolic state) and is a possible facilitator in the β-adrenergic response of plasma glucose to a β-agonist.

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Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

et al. 1999

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“…The typical mode of action of beta-agonists, which elevate muscle protein deposition, is primarily to reduce the muscle protein breakdown-rate in chickens (Hamano et al, 1994(Hamano et al, , 1995Morgan et al, 1989;Muramatsu et al, 1990). The clenbuterol-induced muscle hypertrophy (an increased protein/DNA ratio that is an index of muscle cell size) was related to the effects of dietary protein on DNA concentration.…”

Section: Discussionmentioning

confidence: 97%

“…It is well known that dietary supplementation with beta-adrenergic agonists (beta-agonist) brings about an increase in protein deposition and/or a decrease in fat accretion in growing animals (Dalrymple et al, 1984;Hamano et al, 1995;Yang and McElligott, 1989). In addition, the action of betaagonist, while leading to growth promotion, are likely to change the nutritional states or dietary requirements of the animals (Reeds and Mersmann, 1991;Wellenreiter, 1991).…”

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confidence: 97%

Combined effects of clenbuterol and various concentrations of protein on performance of broiler chickens

Hamano

Kume²,

Yamazaki³

et al. 1998

British Poultry Science

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1. The effects of the beta-adrenergic agonist, clenbuterol (1 mg/kg diet) on the growth and muscle composition in female broiler chickens (14 to 32 d of age) fed on diets containing various concentrations of protein (220, 240 or 260 g protein/kg) were examined. 2. Body weight gain over the 18 d period increased linearly with increasing protein intake. The rate of gain was significantly higher in clenbuterol-treated chickens than in control birds. 3. Dietary clenbuterol increased thigh muscle weight and protein concentration of breast and thigh muscle, regardless of dietary protein content. Protein/DNA ratio in thigh muscle was enhanced by clenbuterol feeding, and the magnitude of difference of the ratio was higher in chickens fed on the 240 and 260 g CP/kg diets than in those fed the 220 g CP/kg diet. 4. It was concluded that clenbuterol-treated chickens require increased dietary protein to maintain maximal growth, and that increased protein consumption is an important factor in improving growth in clenbuterol-fed broilers.

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Effects of a β-Adrenergic Agonist (Clenbuterol) on Growth and Muscle Composition in Broiler Chicks Treated with or without Thyroxine

Cited by 2 publications

References 21 publications

Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

Involvement of lipoic acid in plasma metabolites, hepatic oxygen consumption, and metabolic response to a β-agonist in broiler chickens

Combined effects of clenbuterol and various concentrations of protein on performance of broiler chickens

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