2023
DOI: 10.1186/s43042-022-00379-6
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Effects of ABCG2 C421A and ABCG2 G34A genetic polymorphisms on clinical outcome and response to imatinib mesylate, in Iranian chronic myeloid leukemia patients

Abstract: Background Chronic myeloid leukemia (CML) is a multifactorial clonal myeloid neoplasm that mainly arises from the Philadelphia chromosome. Even though imatinib mesylate (IM) is considered the gold standard for first-line treatment, a number of CML patients have shown IM resistance that can be influenced by many factors, including pharmacogenetic variability. The present study examined whether two common single nucleotide polymorphisms (SNPs) of ABCG2 (G34A and C421A) contribute to IM resistance… Show more

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“…Considering Table 3, the main techniques used for genotyping were the PCR-RFLP method, validated by direct gene sequencing [24,26,36,38,41] and polymerase chain reaction (PCR) and Sanger sequencing [37,40].…”
Section: Primary Resultsmentioning
confidence: 99%
“…Considering Table 3, the main techniques used for genotyping were the PCR-RFLP method, validated by direct gene sequencing [24,26,36,38,41] and polymerase chain reaction (PCR) and Sanger sequencing [37,40].…”
Section: Primary Resultsmentioning
confidence: 99%