Effects of absorbent materials on a self-emulsifying drug delivery system for a poorly water soluble drug

Abstract

In order to compare the effects of a solid carrier on the formulation of a solid self-microemulsifying drug delivery system (s-SMEDDS), a liquid SMEDDS was prepared with simvastatin. The SMEDDS was optimized using polyoxyl 35 castor oil [Kolliphor Ò EL] as a surfactant (S), diethylene glycol monoethylether [Transcutol Ò P] as a co-surfactant (C), and prophyleneglycol monocaprylate [Capryol 90] as the oil phase (O). The microemulsion area at the surfactant to co-surfactant ratio (1:1) was evaluated, and the SMEDDS at an S and C/O ratio of 7:3 was selected. Four types of adsorbents with high specific areas were used: Aerosil Ò 200, Sylysia Ò 350, Neusilin Ò US2, Neusilin Ò UFL2. SEM, DSC, and PXRD results revealed rough-surfaced particles that represent the amorphous state of s-SMEDDS. The optimized formulation with Neusilin Ò UFL2 markedly improved drug release. The present study concluded that s-SMEDDS was effectively formulated via adsorption with solid carriers.

Citrus sinensis Essential Oil-Based Microemulsions: Green Synthesis, Characterization, and Antibacterial and Larvicide Activities

“…Region of ME showed a narrowing at the interface with a higher amount of water and less surfactant. Similar results of the ternary diagram were reported in the literature, using the same surfactant (Kolliphor EL) with Carpryol 90, castor oil/Capmul MCM 1:1, and corn oil/castor oil/Transcutol P, respectively, as a drug delivery system for poorly water-soluble drugs. According to Zeng et al, the use of short-chain alcohols may increase the region of microemulsions, however, the authors have not reported the optimal ratio between the cosurfactants and surfactants to reach a stable microemulsion.…”

A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved Solubility: Optimization, Characterization, and In Vitro Cytotoxicity Studies

“…When comparing the drug release within 5 min (Q5%) from P5-40-UFL2 and P5-40-US2, P5-40-UFL2 exhibited a higher Q5% value compared withP5-40-US2, which was aligned with Park's study [35] reporting that Neusilin US2 used in the formulation of P5-40-US2 had a larger particle size and a similar specific surface area compared with Neusilin UFL2 which was used in formulation P5-40-UFL2. Therefore, this result could be due to the presence of larger numbers of long and narrow intra-particular pores where DFX could entrap inside these pores and cause a slightly less percentage of released DFX.…”

Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan with improved dissolution and bioavailability

“…Various types of solid carriers have been extensively investigated to solidify SMEDDS, including silica-based water-insoluble adsorbents (e.g., porous silica, magnesium aluminometasilicate, and calcium silicate), cellulose-based hydrophilic diluents (e.g., microcrystalline cellulose, hydroxypropyl cellulose, and low-substituted hydroxypropyl cellulose), and saccharide-based water-soluble diluents (e.g., maltodextrin, lactose, and starch) [ 7 – 11 ]. Although adsorbents with high oil-absorbing capacity minimize the quantity required to solidify the SMEDDS, incomplete desorption of SMEDDS components may occur due to hydrophobic interactions between the drug and adsorbents [ 8 ].…”