Effects of Absorbent on the Dissolution Rate of PEG-Based Solid Dispersions Containing Poorly Water-Soluble Drug

Ngo, Hai V.; Ngo, Vy Tran-Khanh; Vo, Vi Tuong; Nguyen, Phuc Kien; Van, Toi Vo; Tran, Phuong Ha-Lien; Tran, Thao

doi:10.1007/978-981-10-4361-1_87

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The workflow of the device Is not complicated: after a QuantStudio digital chip loaded with a solution consisting of the sample, RT-RPA, and the CRISPR/Cas12a reaction system is inserted into the platform, RT-RPA occurs at a set constant temperature (42 °C), generating a large number of amplicons to activate CRISPR/Cas12a trans- activation, causing ssDNA-FQ reporters to cut and release fluorescence, which is monitored and recorded in real time by the smartphone’s camera [85] , [86] . And then, the fluorescence images were analyzed by a trained and validated deep learning-based algorithm to quantify HIV RNA [87] .…”

Section: Hiv Detection By Crispr/cas Systemsmentioning

confidence: 99%

HIV infection detection using CRISPR/Cas systems: Present and future prospects

Deng,

Xue

2023

Computational and Structural Biotechnology Journal

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Section: Hiv Detection By Crispr/cas Systemsmentioning

confidence: 99%

HIV infection detection using CRISPR/Cas systems: Present and future prospects

Deng,

Xue

2023

Computational and Structural Biotechnology Journal

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“…Solid dispersion (SD) can also efficiently increase the dissolution rate and solubility of insoluble drugs by changing the size and dispersion within the carrier. Compared with the abovementioned technologies, this strategy has advantages of high drug loading and suitability for industrial production [ 12 , 13 ]. To date, solvent evaporation has been applied to prepare thermosensitive Cur SDs [ 5 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Curcumin-Eudragit® E PO Solid Dispersions with Gradient Temperature through Hot-Melt Extrusion

Zhang

Zhu

et al. 2021

Molecules

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Hot-melt extrusion (HME) has great advantages for the preparation of solid dispersion (SD), for instance, it does not require any organic solvents. Nevertheless, its application to high-melting-point and thermosensitive drugs has been rarely reported. In this study, thermally unstable curcumin (Cur) was used as a drug model. The HME process was systematically studied by adjusting the gradient temperature mode and residence time, with the content, crystallinity and dissolution of Cur as the investigated factors. The effects of barrel temperature, screw speed and cooling rate on HME were also examined. Solubility parameters and the Flory–Huggins method were used to evaluate the miscibility between Cur and carriers. Differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, equilibrium solubility and in vitro and in vivo experiments were used to characterize and evaluate the results. An amorphous Cur SD was successfully obtained, increasing the solubility and release of Cur. In the optimal process, the mass ratio of Cur to Eudragit® E PO (EPO) was 1:4 and the barrel temperature was set at a gradient heating mode (130 °C–135 °C–140 °C–145 °C–150 °C–155 °C–160 °C) at 100 rpm. Related pharmacokinetic test results also showed the improved bioavailability of the drug in rats. In a pharmacodynamic analysis of Sprague–Dawley rats, the Cmax and the bioavailability of the Cur-EPO SD were 2.6 and 1.5 times higher than those of Cur, respectively. The preparation of the amorphous SD not only provided more solubility but also improved the bioavailability of Cur, which provides an effective way to improve the bioavailability of BCS II drugs.

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