Effects of acepromazine on the cardiovascular actions of dopamine in anesthetized dogs

Monteiro, Eduardo Raposo; Neto, Francisco José Teixeira; Castro, V. B.; Campagnol, Daniela

doi:10.1111/j.1467-2995.2007.00328.x

Cited by 25 publications

(41 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Binding to peripheral alpha1-adrenergic receptors may cause phenothiazine to induce peripheral vasodilatation, and consequently tachycardia CORTOPASSI, 2002). This was reported in dogs treated with acepromazine and anesthetized with isoflurane (MONTEIRO et al, 2007;GRASSO et al, 2015) and would corroborate the data in this study, although only the GMO group showed significant changes.…”

Section: Resultssupporting

confidence: 82%

“…Propofol can reduce SBP by 15 to 30%, and the dosedependent manner and the previous or subsequent administration of opioids may potentiate the hypotensive effect of the anesthetic (MAGELLAN; CHEIBUB, 1990). Also, in dogs anesthetized with isoflurane and treated with acepromazine, it was noted that this drug potentiated the hypotensive effects of inhalational anesthetics (MONTEIRO et al, 2007;GRASSO et al, 2015). Such observations corroborate the results of this study, indicating that the phenothiazine associated with the opioids in question may have enhanced the cardiovascular depressant effects of propofol.…”

Section: Resultssupporting

confidence: 81%

See 1 more Smart Citation

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy

Cintra

Duque

Silveira

et al. 2017

SCA

View full text Add to dashboard Cite

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomyEfeitos cardiorrespiratórios e eletrocardiográficos da metadona ou morfina no período perioperatório em cães anestesiados com infusão contínua de propofol e submetidos a ovário-histerectomia AbstractThe aims of this study were compare the electrocardiogram (ECG) and cardiopulmonary effects of methadone or morphine, both injected intravenously (IV) in dogs anesthetized with continuous infusion of propofol. Sixteen healthy female mongrel dogs were used in this study for elective ovariohysterectomy. The animals were allocated in random order into two groups assigned GME (methadone 0.3 mg kg -1 , IV) or GMO (morphine 0.3 mg kg -1 , IV). Parameters were evaluated: heart rate (HR), P-wave amplitude (Ps and PmV), interval between Ps and R waves (PR), QRS duration (QRS), R-wave amplitude (R), duration the interval between the Q and T waves (QT), systolic blood pressure (SBP), rectal temperature (RT), respiratory rate (RR), end tidal of carbon dioxide (ETCO 2 ) and periferic oxyhemoglobin saturation (SpO 2 ). Postoperative analgesia was assessed by mechanical nociceptive stimulus based on the scale proposed by Firth and Haldane (1999) and rescue analgesia based on the visual analogue scale. HR was lower in GME in relation to GMO. The P, PmV, PR, QRS, R and QT values remained within their normality tracks, showing no clinical importance. Apnea and ETCO 2 increased in both groups. There was no difference between groups of the analgesic effects. It can be concluded that methadone and morphine promote similar cardiovascular effects after IV injection during surgery in dogs anesthetized with propofol by continuous rate infusion, however, when methadone used, assisted ventilation is required. In addition, both drugs promote postoperative analgesia until six hours. ResumoO presente estudo teve como objetivo comparar as alterações no eletrocardiograma (ECG) e nos parâmetros cardiorrespiratórios da metadona ou morfina administrada pela via intravenosa (I.V.) em cães anestesiados com infusão intravenosa contínua de propofol. Foram utilizados 16 cadelas, sem raça definida submetidos ao procedimento de ovário-histerectomia. Os animais foram distribuídos aleatoriamente em dois grupos, designados como GME (metadona 0,3 mg kg -1 , I.V.) ou GMO (morfina 0,3 mg kg -1 , I.V.). Os parâmetros avaliados foram frequência cardíaca (FC), tempo e amplitude da onda P (Ps e PmV), intervalo entre as ondas P e R (PR), duração do complexo QRS (QRS), amplitude da onda R (R), duração do intervalo entre as ondas Q e T (QT), pressão arterial sistólica (PAS), temperatura retal (TR), frequência respiratória (f), tensão de dióxido de carbono no final da expiração (ETCO 2 ) e saturação de oxigênio na hemoglobina (SpO 2 ). A analgesia pós-operatória foi verificada seguindo a proposta de Firth e Haldane (1999) e o regaste analgésico baseado na escala análoga v...

show abstract

Section: Resultssupporting

confidence: 82%

Section: Resultssupporting

confidence: 81%

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy

Cintra

Duque

Silveira

et al. 2017

SCA

View full text Add to dashboard Cite

show abstract

“…The reduction in HR is thought to result from increased vagal tone by opioids (HALL et al, 2001;WAGNER, 2002) whereas the reduction in SAP may have resulted from the effects of both the opioid and ACP. Phenothiazines cause a reduction in systemic vascular resistance (SVR) due to competitive antagonism at vascular alpha-1 adrenergic receptors, an effect that lasts for at least 4 hours (MONTEIRO et al, 2007). Additionally, the opioid-induced reduction in HR may have contributed to the reduction in SAP via a reduction in cardiac output (CO) according to the equation: blood pressure=CO x SVR (CUNNINGHAM, 2002).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the sedative effects of morphine, meperidine or fentanyl, in combination with acepromazine, in dogs

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Benzodiazepines cause minimal cardiovascular depression; however, in adult dogs the sedation can be unreliable and dysphoria may occur (Sanchez et al, 2013). Sedation with acepromazine may provide benefit to hypertensive patients due to the α-1 adrenergic blockade it produces (Monteiro et al, 2007). However, the prolonged and irreversible duration of action of acepromazine may impede the treatment of hypotension during anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

“…Acepromazine likely contributed to the subsequent mild hypotension. Furthermore, the long and irreversibly action of acepromazine may have impeded management of blood pressure were it to worsen (Monteiro et al, 2007). If the reflex bradycardia had not responded to the induction of vasodilation, treatment with an anticholinergic such as atropine would have been indicated.…”

Section: Introductionmentioning

confidence: 99%

Anaesthetic management of a unilateral adrenalectomy of an adrenocortical tumour in a dog

Wise¹,

Boveri²

2016

Open Vet J.

View full text Add to dashboard Cite

Adrenalectomies in dogs are being more commonly performed, however anaesthetic management of such cases can be challenging due to the multiple aetiologies of adrenal tumours and the physiological role of adrenal glands. This case report describes the anaesthetic management of a dog with clinical signs of hyperadrenocorticism that underwent unilateral adrenalectomy via laparotomy and discusses anaesthetic preparedness, protocol selection and management of complications for dogs undergoing adrenalectomy.

show abstract

Effects of acepromazine on the cardiovascular actions of dopamine in anesthetized dogs

Cited by 25 publications

References 23 publications

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy

Comparison of the sedative effects of morphine, meperidine or fentanyl, in combination with acepromazine, in dogs

Anaesthetic management of a unilateral adrenalectomy of an adrenocortical tumour in a dog

Contact Info

Product

Resources

About