Effects of acetamiprid and flumethrin on Unio sp. primary cells

Arslan, Pınar; Yurdakök-Dikmen, Begüm; Kuzukiran, Ozgur; Özeren, Saniye Cevher; Filazı, Ayhan

doi:10.1007/s11756-021-00692-2

Cited by 9 publications

(3 citation statements)

References 48 publications

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“…The cytotoxic effects of a pyrethroid insecticide, flumethrin and a neonicotinoid, acetamiprid, were studied on primary cell cultures of the mantle, gill, gonad, and digestive gland tissues of Unio sp. This study showed that, as compared to acetamiprid, flumethrin was more cytotoxic to all tested cells [47] . The risk Quotient of most organophosphate pesticides was found to be higher for daphnia than for fish and algae [23] .…”

Section: Effect On Aquatic Invertebratesmentioning

confidence: 60%

Effect of pesticide toxicity in aquatic environments: A recent review

Kadiru¹,

Patil²,

D’Souza³

2022

Int. J. Fish. Aquat. Stud.

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Pesticides are widely used in modern agriculture to enhance the quantity and quality of yield in an effective and economical manner, leading to improved food security worldwide. Organochlorines, organophosphates, carbamates and pyrethroids are the four major groups of pesticides used. However, with increasing pesticide use, especially in developing countries, the risk of its toxicity caused by them is on the rise. Despite a low per hectare use of pesticides in India, their injudicious use has led to the presence of pesticide residues in both terrestrial and aquatic ecosystems. It has been observed that major riverine ecosystems like Ganges, Yamuna, Cauvery, Tapi and many others show the presence of pesticides in the water column as well as the river bed sediments. Pesticides tend to bioaccumulate in the food chain. Agricultural runoff into aquatic systems raises the risk of exposure of pesticides to non-target species, leading to adverse consequences on the ecosystem. In this review, an attempt has been made to critically review the usage of pesticides in India, their entry into riverine ecosystems and the impact of pesticides on freshwater microorganisms, invertebrates and vertebrates. The review of legislation in India to control pesticide usage shows that proper implementation of the laws is needed on an urgent basis.

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Section: Effect On Aquatic Invertebratesmentioning

confidence: 60%

Effect of pesticide toxicity in aquatic environments: A recent review

Kadiru¹,

Patil²,

D’Souza³

2022

Int. J. Fish. Aquat. Stud.

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“…Flumethrin was found to be less toxic than other pyrethroids to several mosquito species (Bibbs et al 2018 ) but does impact the behaviour of bees at low levels (Tan et al 2013 ). In the single mollusc study identified, death was observed in gonad cells with short term exposure to 300 μg/L (Arslan et al 2021 ).…”

Section: Resultsmentioning

confidence: 99%

A rapid evidence assessment of the potential risk to the environment presented by active ingredients in the UK’s most commonly sold companion animal parasiticides

Wells

Collins

2022

Environ Sci Pollut Res

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A number of parasiticides are commercially available as companion animal treatments to protect against parasite infestation and are sold in large volumes. These treatments are not intended to enter the wider environment but may be washed off or excreted by treated animals and have ecotoxic impacts. A systematic literature review was conducted to identify the existing evidence for the toxicity of the six most used parasiticides in the UK: imidacloprid, fipronil, fluralaner, afoxolaner, selamectin, and flumethrin. A total of 17,207 published articles were screened, with 690 included in the final evidence synthesis. All parasiticides displayed higher toxicity towards invertebrates than vertebrates, enabling their use as companion animal treatments. Extensive evidence exists of ecotoxicity for imidacloprid and fipronil, but this focuses on exposure via agricultural use and is not representative of environmental exposure that results from use in companion animal treatments, especially in urban greenspace. Little to no evidence exists for the ecotoxicity of the remaining parasiticides. Despite heavy usage, there is currently insufficient evidence to understand the environmental risk posed by these veterinary treatments and further studies are urgently needed to quantify the levels and characterise the routes of environmental exposure, as well as identifying any resulting environmental harm.

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“…have cytotoxic effects even at very low doses. 38 In this study, the estrogenic, cytotoxic, apoptotic, and genotoxic effects of flumethrin were determined on MCF-7 cell lines.…”

Section: Discussionmentioning

confidence: 99%

In vitro toxicological assessment of flumethrin’s effects on MCF-7 breast cancer cells

2021

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Pyrethroid pesticides are frequently used for household insect control of insects and in agriculture and livestock. Flumethrin is a pyrethroid that is used against ectoparasites in many animals. The goal of this study was to evaluate the cytotoxic, apoptotic, genotoxic, and estrogenic effects of flumethrin on the mammalian breast cancer cell line (MCF-7). Compared with control groups, a dose-dependent decrease was observed in cell viability at concentrations of 100 µM and higher. The cytotoxic and apoptotic effects detected by LDH assay and AO/EtBr staining increased significantly at a concentration of 1000 µM. The expression of BCL2, which is an anti-apoptotic gene, significantly decreased, whereas BAX, TP53, and P21 expression significantly increased. The results of a comet assay indicated that flumethrin significantly changed tail length, tail % DNA, tail moment, and Olive tail moment in concentrations above 1 and 10 µM. In addition, a 0.1 µM concentration of flumethrin affected ERα receptor mediated cell proliferation and increased transcription of estrogen-responsive pS2 (TFF1) and progesterone receptor (PGR) genes. As a result, flumethrin-induced apoptosis and cytotoxicity at a high concentration, while induced genotoxicity even at lower concentrations. Flumethrin is an endocrine disrupting insecticide with estrogenic effects at very low concentrations.

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Effects of acetamiprid and flumethrin on Unio sp. primary cells

Cited by 9 publications

References 48 publications

Effect of pesticide toxicity in aquatic environments: A recent review

Effect of pesticide toxicity in aquatic environments: A recent review

A rapid evidence assessment of the potential risk to the environment presented by active ingredients in the UK’s most commonly sold companion animal parasiticides

In vitro toxicological assessment of flumethrin’s effects on MCF-7 breast cancer cells

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