Effects of acetamiprid on immune system in female wistar rats

Abstract

A subacute toxicity study of acetamiprid was undertaken in 72 female wistar rats in four groups (18 each). Three different concentrations of acetamiprid (25, 100 and 200 mg/kg of body weight) were administered orally to rats. Untreated rat served as control. The antibody titre of sheep red blood cells (SRBC) in all the treated groups and decrease in cell mediated immune response (CMI) were evaluated by delayed type hypersensitivity reaction to dinitroflurobenzene (DNFB). Our results revealed that in 200 mg/kg body treated rats, there were significant (Pdd0.01) decrease in mean values of total leukocyte count and relative lymphocyte count in rats. Globulin was also decreased significantly (Pdd0.01) in acetamiprid treated rats compared to control. There was a significant decrease (Pdd0.01) in spleen weight in rats treated with 200 mg/kg dose as compared to control. Histopathological examination of spleen revealed depletion of lymphocytes from Malpighian corpuscles in all treated groups in a dose dependent manner. The results indicated that acetamiprid suppressed both CMI and antibody forming ability of lymphocytes.

Acetamiprid Induces Toxicity in Mice under Experimental Conditions with Prominent Effect on the Hematobiochemical Parameters

“…In the present study, significant decrease in total leukocyte count (thousand/cu.mm) was in agreement with the previous observation made by Mondal et al [13] in female rats after oral administrations of acetamiprid. However, El -Shahawy et al [9] in male albino mice after sub-lethal doses of acetamiprid, lead acetate, and cadmium acetate observed increase in white blood cells.…”

“…The present findings of increase in the value of AST was in agreement with the findings of Bhardwaj et al [12] in female rats following administration of Imidacloprid and Zhang et al [1] in male mice following administrations of acetamiprid. Increase in Alkaline phosphatase value was also reported by other workers such as acetamiprid toxicity in female rats [13], acetamiprid in male mice Zhang et al [1], dichlorovos in male mice [15]. The increase in ALP usually occurred due to its increased synthesis due to damaged liver conditions [16].…”

Induced Acetamiprid Toxicity in Mice: A Review

“…The present findings of increase in the value of AST was in agreement with the findings of Bhardwaj et al [7] in female rats following administration of Imidacloprid and Zhang et al [1] in male mice following administrations of acetamiprid. Increase in Alkaline phosphatase value was also reported by other workers such as acetamiprid toxicity in female rats [8], acetamiprid in male mice Zhang et al [1], dichlorovos in male mice [10]. The increase in ALP usually occured due to its increased synthesis due to damaged liver conditions [11].…”

“…A significant decrease in total leukocyte count (thousands/ cu.mm) was observed by Mondal et al [8] in female rats after oral administrations of acetamiprid. However, El -Shahawy et al [4] in male albino mice after sublethal doses of acetamiprid, lead acetate, and cadmium acetate observed increase in white blood cells.…”

Effets toxicologiques et méthodes d’analyse de la lambda-cyhalothrine et de l’acétamipride utilisés dans la protection phytosanitaire du cotonnier au Bénin

“…C'est pour cela que leurs applications dans la rizière de Chine ont été interdits en raison de leur haute toxicité pour les animaux aquatiques (Çakmak et Gorgone, 2003 ;Köprücü et Aydin, 2004 Zhang et al (2011) ont montré chez des souris mâles exposées à l'acétamipride une altération du système reproducteur suite à un effet au niveau du poids des testicules, de l'épididyme, de la vésicule séminale, de la prostate, de la quantité de sperme, du taux de testostérone, de la viabilité et de la motilité des spermatozoïdes. L'acétamipride entraîne également l'épuisement et l'appauvrissement des lymphocytes et des hémorragies chez des rats exposés (Mondal et al, 2009). Il existe peu d'études réalisées sur l'impact de l'acétamipride sur les espèces aquatiques.…”