Effects of Acetate or Bicarbonate Dialysis Solutions on Serum HDL and HDL Subfractions of Patients Undergoing Haemodialysis

Abstract

The aim of this study was to compare the effect of acetate- and bicarbonate-containing dialysis solutions (buffers) on serum lipid (triglyceride and total cholesterol) and lipoprotein (LDL, HDL and its subfractions as HDL2 and HDL3', Apolipoprotein A1 and Apolipoprotein B) values in patients undergoing haemodialysis. Lipid concentrations in 16 patients on bicarbonate and in 18 patients on acetate haemodialysis were investigated initially and after four weeks of dialysis treatment. Over four weeks of treatment both acetate and bicarbonate dialysis treatments had no negative effects on either HDL or HDL subfractions, and these buffering systems were indistinguishable from each other. We confirm that HDL is the major factor that is changed in the lipid profile in haemodialysis patients undergoing acetate or bicarbonate dialysis and suggest that the relation between LDL and HDL subfractions may be useful for monitoring the lipid changes in haemodialysis patients at risk of atherogenesis.

Identification of N‐acetyltaurine as a novel metabolite of ethanol through metabolomics‐guided biochemical analysis

“…In addition, hyperacetatemia also commonly occurs in long term hemodialysis patients after using dialysis fluid containing sodium acetate as buffering agent (65). Hyperacetatemia has been associated with the development of dyslipoproteinemia and atherosclerosis, especially in some hemodialysis patients (66), and has also been recently implicated as a main cause of alcohol hangover headache (67). Moreover, increased serum acetate has been shown as a better marker of problem drinking among drunken driver than ethanol (68).…”