1955
DOI: 10.1016/0006-3002(55)90013-5
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Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices

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Cited by 254 publications
(46 citation statements)
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“…The highest specific activities were attained by the component believed to be phosphatidic acid and by a phosphoinositide which probably has the structure of phosphatidylinositol. These findings are similar to those of Dawson (36) using guinea pig brain and those of Hokin and Hokin (37,38) using pigeon pancreas and guinea pig brain. Rowe (9) reported that cephalin was the most highly labeled phospholipid component in whole blood incubated with P32.…”
Section: Resultssupporting
confidence: 91%
“…The highest specific activities were attained by the component believed to be phosphatidic acid and by a phosphoinositide which probably has the structure of phosphatidylinositol. These findings are similar to those of Dawson (36) using guinea pig brain and those of Hokin and Hokin (37,38) using pigeon pancreas and guinea pig brain. Rowe (9) reported that cephalin was the most highly labeled phospholipid component in whole blood incubated with P32.…”
Section: Resultssupporting
confidence: 91%
“…Yet, it is clear from these (Figs. [3][4][5] and previous studies (18) that medium osmolarity cannot be ignored while probing for metabolic activities in platelet suspensions. Although a biochemical explanation of the observed phenomena must await further study, it is useful for a start to consider some of the more obvious consequences of manipulating medium osmolarity.…”
Section: Discussionmentioning
confidence: 99%
“…Proof of the active turnover of the inositol lipids in tissues other than brain began in 1955 with the studies of Hokin and Hokin (4) on the stimulation by acetylcholine of 'Pt incorporation into phosphoinositide of pancreas slices. Later, it became apparent that in various other tissues, liver (5,6), erythrocytes (7,8), leukocytes (9)(10)(11), and kidney (5,12), the in vitro incorporation of 'Pt was at a very high rate in the inositides.…”
Section: Introductionmentioning
confidence: 99%
“…In the early 1950s, Hokin and Hokin ( 1,2 ) discovered that addition of acetylcholine to brain slices stimulated the incorporation of phosphate and inositol but not glycerol into lipids; the major products of this incorporation were phosphatidylinositol (PI) and phosphatidic acid. Subsequent studies defi ned the reactions of the PI cycle and showed that the initial event was receptor-meditated activation of a phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PI-4,5-P 2 ) to 1,2-diacylglycerol (DG) and inositol 1,4,5-trisphosphate (IP 3 ).…”
Section: The Pi Cyclementioning
confidence: 99%