Effects of acetylsalicylic acid and metamizol on hyaluronidase activity and sperm characteristics in rams

Tanyıldızı, Sadettin; Bozkurt, Tanzer

doi:10.1016/s0378-4320(03)00002-2

Cited by 13 publications

(12 citation statements)

References 16 publications

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“…the effects of metamizole on hyaluronidase activity of semen and sperm characteristics in rams were investigated by tanyildizi and Bozkurt (95). Metamizole caused an increase in the hyaluronidase activities and spermatozoa motilities, and significantly decreased the sperm concentrations and semen volumes.…”

Section: Reproductive and Developmental Toxicitymentioning

confidence: 99%

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile

Nikolova

Tencheva

Voinikov

et al. 2012

Biotechnology & Biotechnological Equipment

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Section: Reproductive and Developmental Toxicitymentioning

confidence: 99%

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile

Nikolova

Tencheva

Voinikov

et al. 2012

Biotechnology & Biotechnological Equipment

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“…Semen hyaluronidase activity could be an index of fertilization ability [13] and there is no published report on the effects of levamisole on sperm characteristics and hyaluronidase activity of serum and semen. Levamisole are commonly in veterinary practice in Turkey.…”

Section: Introductionmentioning

confidence: 99%

Effects of levamisole on hyaluronidase activity and sperm characteristics in rams

2004

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The aim of this study was to determine the effects of levamisole on sperm characteristics and hyaluronidase activity of blood serum and semen. For this purpose, 12 Akkaraman rams (2-3 years old) were used. Levamisole hydrochloride was administered orally at a dose of 7.5mg/kg body weights once daily for 2 days. Serum and semen samples were collected from the rams at post-treatment 1, 2, 4, 24, 48, 72, 96, 120, 144, 216, 288 and 384 h and examined for sperm characteristics and hyaluronidase activity. The results showed that the use of levamisole caused significant (P < 0.01) increase in serum hyaluronidase activity at all times except the 72 h, and in semen hyaluronidase activity at 1, 2, 4, 24, 72, 96 and 120 h compared to the control group. In addition, the levamisole caused significant (P < 0.05) decreases in semen volume, sperm motility, concentration and total sperm number at all times. There was no correlation between semen hyaluronidase activity and the sperm characteristics. In conclusion, levamisole did not have any deleterious effect on hyaluronidase enzyme. However, the use of this drug in rams during the breeding season is harmful due to the decrease of sperm characteristics.

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“…Similarly, Kolesarova et al (2012) demostrated stimulatory effect of resveratrol, a natural polyphenol, on the progesterone release by porcine ovarian GCs at the doses 50 μg/mL but not at 30 and 10 μg/mL. Previous studies examined the effects of natural compounds on different parts of animal reproductive system (Kolesárová et al, 2012a,b;Tanyildizi and Bozkurt, 2004;Halenár et al, 2013b;Yasui et al, 2003;Randel et al, 1992). Likewise, cultured HTB-35 cells line, as a model of cervical carcinoma, was used for the evaluation anticancer properties of amygdalin.…”

Section: Discussionmentioning

confidence: 96%

“…There are many studies which have described the effects of different natural substances on the secretory activity of porcine (Medveďová et al, 2011, Ranzenigo et al, 2008 and rats ovarian cells (Kolesárová et al, 2011). The adverse impacts of various naturally cyanidecontaining substances on the motility and morphological abnormality of bull sperm, were observed previously (Tanyildizi and Bozkurt, 2004). Steroid hormones, such as progesterone and estradiol, are produced by ovarian cells and both play irreplaceable role in ovarian cycles (Hagan et al, 2009;Arnhold et al, 2009), contribute to regulation of ovarian follicular development and remodeling (Mahajan, 2008).…”

Section: Discussionmentioning

confidence: 99%

Ovarian Hormone Production Affected by Amygdalin Addition in Vitro

Halenár¹,

Medvedova²,

Maruniaková³

et al. 2015

J microb biotech food sci

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Amygdalin, a natural substance, is a cyanogenic glycoside occurring in the seeds of apricots and bitter almonds. It is a controversial anti-tumor compound that has been used as an alternative cancer drug for many years. Amygdalin is composed of two molecules of glucose, one of benzaldehyde, which induces an analgesic action, and one of hydrocyanic acid, which is an anti-neoplastic compound. This in vitro study was performed to evaluate the possible impact of amygdalin (1, 10, 100, 1000, 10 000 μg/mL) on the secretory activity of granulosa cells (GCs) from porcine cyclic ovaries. The release of progesterone and estradiol-17β by GCs were evaluated by ELISA. In our study, the noticeable changes in estradiol-17β release by ovarian GCs were determined after the amygdalin addition. Amygdalin, at the highest dose (10 000 μg/mL), significantly (P≤0.05) stimulated the release of estradiol-17β by GCs, in comparison to the untreated control cells. On the contrary, no significant (P≥0.05) changes in the progesterone release by GCs caused by amygdalin addition were observed. In conclusion, obtained results showed that the amygdalin application (various doses) to ovarian GCs caused a dose-dependent stimulation of the estradiol-17β release, but not progesterone, and its possible modulatory impact on the steroid production in porcine ovaries.

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Effects of acetylsalicylic acid and metamizol on hyaluronidase activity and sperm characteristics in rams

Cited by 13 publications

References 16 publications

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile

Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile

Effects of levamisole on hyaluronidase activity and sperm characteristics in rams

Ovarian Hormone Production Affected by Amygdalin Addition in Vitro

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