Effects of acid activation on the halloysite nanotubes for curcumin incorporation and release

Pereira, Vanessa de Abreu; Paz, Iara dos Santos; Gomes, Amanda Lima; Leite, Lorena Alves; Fechine, Pierre Basílio Almeida; Filho, Mén de Sá Moreira de Souza

doi:10.1016/j.clay.2020.105953

Cited by 27 publications

(6 citation statements)

References 49 publications

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“…Notwithstanding its potency, its clinical utility is encumbered by meager bioavailability and swift degradation. [ 60 ] Numerous inquiries have been channeled toward refining HNTs for augmented drug conveyance capacities, especially in the context of curcumin.…”

Section: Halloysite Nanotubes In Cancer Treatmentmentioning

confidence: 99%

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

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Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina and silica layers, endowing them with a large surface area and versatile surface chemistries that facilitate selective modifications. Moreover, their substantial pore volume and wide range of pore sizes enable efficient entrapment of diverse functional molecules. This comprehensive review highlights the broad biomedical application spectrum of HNTs, shedding light on their potential as innovative and effective therapeutic agents across various diseases. It emphasizes the necessity of optimizing drug delivery techniques, developing targeted delivery systems, rigorously evaluating biocompatibility and safety through preclinical and clinical investigations, exploring combination therapies, and advancing scientific understanding. With further advancements, HNTs hold the promise to revolutionize the pharmaceutical industry, opening new avenues for the development of transformative treatments.

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Section: Halloysite Nanotubes In Cancer Treatmentmentioning

confidence: 99%

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

Small

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“…Halloysite is a natural tubular clay, and one of the most studied, due to its biocompatibility (with low in vivo and in vitro toxicity) and mechanical, physical and chemical (simple inner/outer surfaces functionalization) properties. Due also to its tubular form, it can be loaded with different species to be used for the release of active molecules such as antioxidants [ 172 ], flame-retardants, corrosion inhibitors [ 173 ], biocides and drugs [ 174 ]. In this regard, there are many examples of the use of halloysite loaded or functionalized with different nanomaterials, such as metal or magnetic NPs, for environmental remediation approaches, that are able either to perform pollutant degradation catalytic reactions or to be used as recoverable absorbent systems.…”

Section: Silica-based Nanomaterialsmentioning

confidence: 99%

Functional Nanohybrids and Nanocomposites Development for the Removal of Environmental Pollutants and Bioremediation

et al. 2022

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World population growth, with the consequent consumption of primary resources and production of waste, is progressively and seriously increasing the impact of anthropic activities on the environment and ecosystems. Environmental pollution deriving from anthropogenic activities is nowadays a serious problem that afflicts our planet and that cannot be neglected. In this regard, one of the most challenging tasks of the 21st century is to develop new eco-friendly, sustainable and economically-sound technologies to remediate the environment from pollutants. Nanotechnologies and new performing nanomaterials, thanks to their unique features, such as high surface area (surface/volume ratio), catalytic capacity, reactivity and easy functionalization to chemically modulate their properties, represent potential for the development of sustainable, advanced and innovative products/techniques for environmental (bio)remediation. This review discusses the most recent innovations of environmental recovery strategies of polluted areas based on different nanocomposites and nanohybrids with some examples of their use in combination with bioremediation techniques. In particular, attention is focused on eco-friendly and regenerable nano-solutions and their safe-by-design properties to support the latest research and innovation on sustainable strategies in the field of environmental (bio)remediation.

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“…Basically built with kaolinite structure has layered structured (d 001 value of 10 Angstrom) occupied inbetween by water molecules ( Barman et al, 2020 ). The external adsorption site (specific surface area) of Hal can be modified by treatment with HCl for effective drug incorporation and influence the release rate of antioxidant such as curcumin ( de Abreu Pereira et al, 2021 ). Halloysite with high tubular surface area, biocompatibility, functionable aluminol and siloxane moieties has been used as a controlled drug release carriers for cancer ( Mo et al, 2021 ), tissue engineering ( Gkouma et al, 2021 ), diabetes mellitus ( Massaro et al, 2018 ), dental ( Karczewski et al, 2021 ), herbicide ( Tan et al, 2015 ), etc.…”

Section: Introductionmentioning

confidence: 99%