Effects of Acidosis on Cardiovascular Function in Surgical Patients

Clowes, G. H. A.; Sabga, Gabriel; Konitaxis, A.; Tomin, R; Hughes, Mary J.; Simeone, F. A.

doi:10.1097/00000658-196110000-00005

Cited by 90 publications

(14 citation statements)

References 31 publications

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“…In a second group of 15 patients whose post-operative cardiac indices were less than 2 litres per minute and whose pulmonary arterial saturation fell below 50% on one or more occasions, the average A-V difference was approximately 8 vol.%; only five of these patients survived the first few days following operation. Clowes, Sabga, Konitaxis, Tomin, Hughes, and Simeone (1961) have also made measurements of cardiac output after open-heart surgery. Using the dye technique, they showed that, if no significant metabolic acidosis was present, cardiac output was generally increased after operation.…”

Section: Oxygen Transfer (Tables M and Iv)mentioning

confidence: 99%

Respiratory Changes After Open-heart Surgery

McClenahan¹,

Young²,

Sykes³

1965

Thorax

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Section: Oxygen Transfer (Tables M and Iv)mentioning

confidence: 99%

Respiratory Changes After Open-heart Surgery

McClenahan¹,

Young²,

Sykes³

1965

Thorax

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“…Hence to elucidate the second possibility. which seemed more probable because of evidences of direct myocardial depressant effect of metabolic acidosis (24,25), a few biopsy studies of the lung were done in open thorax dogs, before and during profound metabolic acidosis (pH: 7.15; BD: 16 mEq per liter; Paco2: 40 mm Hg). A representative sample from this histopathologic study is given in figure 5.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Acidosis and Lung Mechanics in Dogs

Sinha¹,

Tinker²,

Hizon³

et al. 1972

Am Rev Respir Dis

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__________________________________________________ ___The changes in lung mechanics, e.g., dynamic compliance, expiratory airway resistance, and the components of the work of breathing, i.e., total work, elastic work, resistive work, and negative work were studied at constant tidal volume during the following conditions: (1) increased frequency of breathing from a control rate of 10 to 40 breaths per minute in increments of 5 per minute while acid-base status was held constant; (2) induced acute metabolic lactic acidosis with a fixed arterial carbon dioxide tension and breathing rate of 10 breaths per minute; (3) during increased frequency of breathing superimposed on profound metabolic acidosis. The effect on lung mechanics of increased frequency of breathing combined with metabolic acidosis was considerably greater than the effect of frequency of breathing or acidosis alone. The deleterious effect of metabolic acidosis on lung mechanics is accentuated by the increased work of breathing that results from the concomitant increase of respiratory frequency.

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“…We know that acidosis lowers the cardiac output (Clowes, Sabga, Konitaxis, Tomin, Hughes, and Simeone, 1961;Ebert, Greenfield, Austin, and Morrow, 1962) and if severe enough will produce ventricular fibrillation and death. We know also that alkalosis produces tetany and convulsions and diminished cerebral circulation.…”

Section: Problems In Acid-base Balancementioning

confidence: 99%

Acid-base balance

Walker

1967

Journal of British Surgery

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Effects of Acidosis on Cardiovascular Function in Surgical Patients

Cited by 90 publications

References 31 publications

Respiratory Changes After Open-heart Surgery

Respiratory Changes After Open-heart Surgery

Metabolic Acidosis and Lung Mechanics in Dogs

Acid-base balance

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