1988
DOI: 10.1172/jci113690
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Effects of active vitamin D3 and parathyroid hormone on the serum osteocalcin in idiopathic hypoparathyroidism and pseudohypoparathyroidism.

Abstract: Serum osteocalcin was measured in patients with idiopathic hypoparathyroidism or pseudohypoparathyroidism, before or during the treatment with active vitamin D3 (1,25(OH)2D3 or lcaOHD3).Serum osteocalcin and plasma 1,25(OH)2D were decreased in 11 patients with idiopathic hypoparathyroidism before treatment (2.8±1.27 ng/ml, P < 0.001 and 14.3±4.27 pg/ml, P <0.001, respectively). In 24 patients with idiopathic hypoparathyroidism during the treatment, serum osteocalcin and plasma 1,25(OH)2D were within the normal… Show more

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Cited by 30 publications
(8 citation statements)
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“…BGP secretion of osteoblast-like cells is known to be stimulated by 1,25 (OH)2D3 in vitro, a most potent metabolite of vitamin Da (2s). Similar in vivo results have been observed in hypoparathyroidism (29), chronic renal failure (a~ and osteoporosis (31) with vitamin D deficiency, whose serum levels of BGP were raised by short-term administrations of active forms of vitamin Da.…”
Section: Discussionsupporting
confidence: 77%
“…BGP secretion of osteoblast-like cells is known to be stimulated by 1,25 (OH)2D3 in vitro, a most potent metabolite of vitamin Da (2s). Similar in vivo results have been observed in hypoparathyroidism (29), chronic renal failure (a~ and osteoporosis (31) with vitamin D deficiency, whose serum levels of BGP were raised by short-term administrations of active forms of vitamin Da.…”
Section: Discussionsupporting
confidence: 77%
“…This disorder is characterized by markedly reduced bone remodeling due to the absence or markedly reduced presence of PTH (3)(4)(5). Chronically reduced bone turnover in patients with hypoparathyroidism typically leads to increased bone mass compared to that in ageand sex-matched controls (6)(7)(8)(9)(10)(11).…”
Section: Introductionmentioning
confidence: 99%
“…(4)(5)(6)(7) Independent of etiology, the typical biochemical constellation in untreated hypoparathyroidism includes low circulating PTH levels, hypocalcemia, relatively high urinary calcium excretion, hyperphosphatemia, and reduced levels of 1,25-dihydroxyvitamin D. (8,9) In the absence of PTH, bone remodeling is reduced. (10)(11)(12) Chronically low bone turnover in patients with hypoparathyroidism typically leads to bone mass that is higher than age-and sex-matched controls. (13)(14)(15)(16) This study was designed to provide a detailed description of the structural and dynamic features of the skeleton in hypoparathyroidism.…”
mentioning
confidence: 99%