Effects of acupuncture on nutritional state of patients with stable chronic obstructive pulmonary disease (COPD): re-analysis of COPD acupuncture trial, a randomized controlled trial

Suzuki, Masao; Muro, Shigeo; Fukui, Motonari; Ishizaki, Naoto; Satô, Susumu; Shiota, Tetsuhiro; Endo, Kazuo; Suzuki, Tomoko; Mitsuma, Tadamichi; Mishima, Michiaki; Hirai, Toyohiro

doi:10.1186/s12906-018-2341-3

Cited by 27 publications

(21 citation statements)

References 39 publications

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“…The improvements in pulmonary functions and nutritional status observed in previous papers were not replicated in our study,13,25 although the same acupuncture points were used. However, we used a thinner needle (0.16 mm vs 0.35 mm) in this study because of the weak pain stimulus.…”

Section: Discussioncontrasting

confidence: 81%

<p>Clinical Effects Of Acupuncture On The Pathophysiological Mechanism Of Chronic Obstructive Pulmonary Disease During Exercise</p>

Maekura

Miki

et al. 2019

COPD

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PurposePharmacological therapy and pulmonary rehabilitation are useful for exertional dyspnoea in patients with chronic obstructive pulmonary disease (COPD); however, several patients have no meaningful improvements. Although acupuncture significantly improves exercise intolerance and dyspnoea, the pathophysiological mechanism of these effects is unknown; therefore, we evaluated this mechanism using cardiopulmonary exercise testing in a single-arm, open experimental study.Patients and methodsSixteen patients with COPD underwent acupuncture once a week for 12 weeks. Primary outcomes were exercise performance parameters, including peak oxygen uptake in the incremental exercise tests (IETs) and the time to the limit of tolerance measured in constant work rate exercise tests (CWRETs) at 70% peak work-rate of the IET. IETs and CWRETs were performed at baseline and at weeks 12, 16, and 24.ResultsDuring the time course, there were significant increases in peak oxygen uptake (p = 0.018) and minute ventilation (V̇E, p = 0.04) in the IETs. At 12 weeks, the endurance time significantly increased (810 ± 470 vs 1125 ± 657 s, p < 0.001) and oxygen uptakes at terminated exercise were significantly lower (771 ± 149 mL/min, p < 0.05) than those at baseline (822 ± 176 mL/min) in CWRETs. The significant decreases in oxygen uptake and minute ventilation and improvements in Borg scale scores were also observed during CWRETs after acupuncture. The decreases at isotime in the Borg scale (r = −0.789, p = 0.0007) and V̇E (r = −0.6736, p = 0.0042) were significantly correlated with the improvement of endurance time.ConclusionThe positive effects of acupuncture on exertional dyspnoea were associated with increased endurance time influenced by improved oxygen utilisation and reduced ventilation during exercise. Acupuncture may be a new intervention for COPD in addition to conventional maintenance therapies.

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Section: Discussioncontrasting

confidence: 81%

<p>Clinical Effects Of Acupuncture On The Pathophysiological Mechanism Of Chronic Obstructive Pulmonary Disease During Exercise</p>

Maekura

Miki

et al. 2019

COPD

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“…Acupuncture improved peak oxygen uptake, peak minute ventilation, time to the limit of tolerance, and total SGRQ score of patients with COPD (44). Acupuncture also improved the nutritional state of patients with COPD, including body weight, respiratory muscle strength, nutritional hematological examination, and inflammatory biomarkers (6). According to the previous association rule analysis, ST36, BL12, and CV17 and ST36, BL12, and EXB1 could be considered the core acupoint combinations for the treatment of COPD (45).…”

Section: Discussionmentioning

confidence: 92%

Acupuncture Point Stimulation Treatments Combined With Conventional Treatment in Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis

Tsai

Cui

et al. 2021

Front. Med.

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Background: Chronic obstructive pulmonary disease (COPD), which is a disease characterized by dyspnea, cough, and respiratory symptoms, leading to impaired health-related quality of life (HRQL) and exercise capacity, is highly prevalent worldwide. Some studies demonstrated that acupuncture point stimulation treatments (APSTs) are effective and safe in treating patients with COPD. The aim of this systematic review and network meta-analysis is to analyze the effects on HRQL and FEV1% predicted of diverse APSTs in treating patients with COPD.Materials and Methods: We searched seven electronic databases. Randomized controlled trials (RCTs) with stable COPD patients comparing APSTs and conventional treatment (Tx) were included. The primary outcome was HRQL measured by COPD Assessment Test or St. George's Respiratory Questionnaire. The secondary outcome was FEV1% predicted. We performed random effect network meta-analysis using a consistency model.Results: This network meta-analysis analyzed 21 RCTs with 1,577 stable COPD participants. In comparison with Tx, acupressure massage (AM) + Tx [−5.11; 95% confidence interval (CI), −6.65 to −3.57] was the most effective intervention in improving HRQL, followed by moxibustion (Mx) + Tx (−2.86; 95% CI, −3.86 to −1.86). Moreover, in comparison with Tx, Mx + Tx (7.79; 95% CI, 2.16 to 13.42) was the most effective intervention in improving FEV1% predicted, followed by acupuncture (A) + Tx (5.79; 95% CI, 2.90 to 8.68).Conclusions: Combined interventions (APSTs + Tx) are more effective than single intervention in improving both HRQL and FEV1% predicted. AM, Mx, and A can be considered effective non-pharmacological complementary interventions in treating patients with COPD under Tx.

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“… 30 Previous researches have shown that acupuncture is an effective in the treatment of for COPD. 8 , 13 , 14 This overview provided a comprehensive mapping of the evidence on the effectiveness of acupuncture for COPD. A total of 9 SRs were included in this overview, the evaluation with AMSTAR 2 showed that the quality of included SRs was low or critically low and the results of the GRADE system evaluation showed that the strength of evidence was very low to low for most outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] Proponents argue that acupuncture is effective at relieving symptoms and improving quality of life and activity endurance, and it is associated with fewer adverse effects than conventional approaches used to treat COPD. 11 In recent years, with the increasing number of clinical studies [12][13][14] on acupuncture treatment of COPD, a certain number of systematic reviews (SRs) [15][16][17][18][19][20][21][22][23] have been published to provide corresponding evidence supporting clinical decision-making. However, based on preliminary studies, the results of different systematic evaluations are not completely consistent, which are unable to effectively guide clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Role of Acupuncture in the Treatment of COPD: An Overview of Systematic Reviews

Liu¹,

Li²,

Feng³

et al. 2021

IJGM

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Background Since consistent evidence on the effectiveness of acupuncture in the treatment of chronic obstructive pulmonary disease (COPD) is not available, this overview aims to summarize and critically evaluate the methodological and evidence quality of systematic reviews (SRs) on this topic. Methods Eight electronic databases were searched to identify relevant SRs of the use of acupuncture in the treatment of COPD from inception to January 2021. Two researchers independently screened the literature, extracted the data, and cross-checked the data. The Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR 2) list was used to assess the methodological quality of SRs. The Grades of Recommendations, Assessment, Development and Evaluation (GRADE) system was used to assess the quality of evidence for the outcomes of interest. Results Nine SRs that conducted quantitative syntheses were included in this overview. The methodological quality of the SRs and the quality of evidence for the main outcome measures were generally unsatisfactory. Only 2 SRs were rated as low methodological quality by AMSTAR 2, and the remaining SRs were rated as critically low quality. The key limitations of the SRs were lack of a protocol and registration or a list of excluded studies. We did not find high-quality evidence to confirm the effectiveness of acupuncture for COPD, and the main reason was that the qualitative data synthesis relied on trials with small sample sizes and critically low quality. Conclusion Acupuncture appears to be an effective therapeutic method for COPD, but the credibility of the results is limited owing to the generally low methodological quality and evidence quality of the included SRs. Further rigorous and comprehensive studies are required to provide robust evidence and draw definitive conclusions.

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Effects of acupuncture on nutritional state of patients with stable chronic obstructive pulmonary disease (COPD): re-analysis of COPD acupuncture trial, a randomized controlled trial

Cited by 27 publications

References 39 publications

<p>Clinical Effects Of Acupuncture On The Pathophysiological Mechanism Of Chronic Obstructive Pulmonary Disease During Exercise</p>

<p>Clinical Effects Of Acupuncture On The Pathophysiological Mechanism Of Chronic Obstructive Pulmonary Disease During Exercise</p>

Acupuncture Point Stimulation Treatments Combined With Conventional Treatment in Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis

Role of Acupuncture in the Treatment of COPD: An Overview of Systematic Reviews

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