Effects of acupuncture on obstructive sleep apnea severity, blood pressure control and quality of life in patients with hypertension: A randomized controlled trial

Silva, Marcus Vinícius F. P.; Lustosa, Thais C.; Arai, Victor J.; Patriota, Tarcya L.G Couto; Lira, Maria Priscila Figueiredo; Lins-Filho, Ozeas L; Chalegre, Sintya Tertuliano; B.B.A.S., Kamilla; Secundo, Isaac Vieira; Pedrosa, Rodrigo Pinto

doi:10.1111/jsr.12954

Cited by 11 publications

(4 citation statements)

References 24 publications

(57 reference statements)

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“…This is considered to be a neuromuscular compensatory mechanism in which 5‐hydroxytryptamine (5‐HT) plays an important role. Silva et al proved that acupuncture can activate caudal raphe 5‐HT pathways and release serotonergic neurotransmitters, thereby increasing the excitatory drive of the upper airways and reducing collapse (Silva et al, 2020). Taken together, the above findings support a positive effect of acupuncture on OSAHS, and this is consistent with the present findings.…”

Section: Discussionmentioning

confidence: 99%

Effects of acupuncture on obstructive sleep apnea–hypopnea syndrome: A meta‐analysis

Lin

Kong

Chen

et al. 2023

Research in Nursing & Health

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Our study aimed to systematically evaluate the effect of acupuncture in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Literature search of four Chinese databases and six English databases for studies published from the inception of each database to March 1, 2022 and identify relevant studies published in Chinese or English. Related randomized controlled trials of acupuncture for the treatment of OSAHS were included to analyze the efficacy of acupuncture. Two researchers independently reviewed all of the retrieved studies to screen for eligible studies and extract the required relevant data. Included studies were subjected to a methodological quality assessment using the Cochrane Manual 5.1.0, and to a meta-analysis using Cochrane Review Manager version 5.4. A total of 19 studies with 1365 participants were examined. Compared with the control group, the apnea-hypopnea index, lowest oxygen saturation, Epworth Sleepiness Scale, interleukin-6, tumor necrosis factor α, and nuclear factor κ-B indicators all exhibited statistically significant changes. Thus, acupuncture was effective in alleviating the state of hypoxia and sleepiness and reduced the inflammatory response and disease severity among reported patients with OSAHS. Therefore, acupuncture could be widely used in the clinical treatment of OSAHS patients as a complementary strategy and warrants further study.acupuncture, complementary and alternative therapies, meta-analysis, obstructive sleep apneahypopnea syndrome, randomized controlled trials | INTRODUCTIONObstructive sleep apnea-hypopnea syndrome (OSAHS) is an increasingly prevalent disorder in which the upper airway is narrowed or closes during sleep, causing hypopnea or apnea. The pathophysiology of OSAHS is multifactorial and includes airway narrowing due to altered upper airway anatomical and functional aspects and increased pharyngeal collapse due to impairment of muscle responsiveness, arousability and respiratory drive (Rajesh et al., 2021). Recent studies have estimated that nearly 1 billion adults worldwide experience OSAHS, with approximately 42% of these individuals affected by moderate to severe OSAHS (Benjafield et al., 2019). Furthermore, about 14.5% of children with sleep-disordered breathing may have severe OSAHS (Bains et al., 2020). Patients often manifest intermittent hypoxia and excessive daytime sleepiness which can lead to fatigue, impaired attention, and an increased risk of accidents.

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Section: Discussionmentioning

confidence: 99%

Effects of acupuncture on obstructive sleep apnea–hypopnea syndrome: A meta‐analysis

Lin

Kong

Chen

et al. 2023

Research in Nursing & Health

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“…Patients were given conventional symptomatic support and sham acupuncture treatments in the sham acupuncture group. Sham acupuncture procedure: During the sham acupuncture treatment, the therapeutic needle is inserted approximately 1 inch away from the actual acupuncture point, while the remaining procedures are consistent with the verum acupuncture treatment [ 26 ]. Patients in both groups were given conventional education, psychological support, sleep counseling, and exercise instruction.…”

Section: Methodsmentioning

confidence: 99%

Acupuncture improves immunity and fatigue after chemotherapy in breast cancer patients by inhibiting the Leptin/AMPK signaling pathway

Li,

Fu,

Guo

et al. 2023

Support Care Cancer

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Objective Acupuncture has become a popular complementary treatment in oncology. This study is based on RNA-Seq transcriptome sequencing technology to investigate the molecular mechanisms underlying the effect of acupuncture-mediated regulation of the Leptin/AMPK signaling pathway on mitochondrial dysfunction-induced fatigue in breast cancer patients after chemotherapy. Methods Peripheral blood samples from 10 patients with post-operative chemotherapy for breast cancer were selected for transcriptome sequencing to screen the key molecular pathways involved in fatigue after chemotherapy in breast cancer patients. Besides, peripheral blood samples were collected from 138 post-operative chemotherapy patients with breast cancer to study the composite fatigue and quality of life scores. Flow cytometry was used to detect T lymphocyte subsets in peripheral blood-specific immune cells. In addition, a blood cell analyzer was used to measure peripheral blood leukocyte counts, and MSP-PCR was used to detect mitochondrial DNA mutations in peripheral blood leukocytes. Results Transcriptome bioinformatics analysis screened 147 up-regulated mRNAs and 160 down-regulated mRNAs. Leptin protein was confirmed as the key factor. Leptin was significantly higher in the peripheral blood of breast cancer patients who developed fatigue after chemotherapy. Acupuncture treatment effectively improved post-chemotherapy fatigue and immune status in breast cancer patients, suppressed the expression of Leptin/AMPK signaling pathway-related factor and leukocyte counts, and significantly reduced the rate of mitochondrial DNA mutations in peripheral blood leukocytes. Conclusion The Leptin/AMPK signaling pathway may be the key molecular pathway affecting the occurrence of fatigue after chemotherapy in breast cancer patients. Leptin may improve post-chemotherapy fatigue in breast cancer patients by activating AMPK phosphorylation and alleviating mitochondrial functional impairment.

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“…In an RCT study involving forty-four patients with obstructive sleep apnea and comorbid hypertension, there were no differences in pre-intervention and post-intervention AHI, daytime or nocturnal BP, or quality of life between the acupuncture and control groups. This leads to the conclusion that acupuncture therapy does not reduce the severity of obstructive sleep apnea, daytime or nocturnal BP, or quality of life in patients with obstructive sleep apnea and comorbid hypertension (41).…”

Section: Clinical Effect Of Acupuncture On Obstructive Sleep Apneamentioning

confidence: 99%

Efficacy of Acupuncture in the Treatment of Obstructive Sleep Apnea: A Review

Samadi,

Mehrain,

Kheirollahi

et al. 2024

Arch Neurosci

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Context: Obstructive sleep apnea is one of the most common sleep disorders, and it is associated with several conditions, including cardiovascular diseases and neuropsychiatric events. Due to its significant burden and increasing prevalence, the treatment of obstructive sleep apnea is of great importance. Evidence Acquisition: Continuous airway pressure (CPAP) has been the standard treatment for managing clinically significant obstructive sleep apnea in recent decades. However, compliance with CPAP treatment is as low as 60% in patients with obstructive sleep apnea. Additionally, CPAP only suppresses respiratory disturbances during sleep while using the devices and does not provide a permanent resolution. Given the limitations of prevalent treatments for obstructive sleep apnea, various alternative therapies have been explored. Among these, acupuncture is a traditional yet novel treatment for obstructive sleep apnea. Acupuncture is widely accepted by many people and specialists in different fields and is commonly used to treat various conditions. Several studies have shown that acupuncture effectively improves the apnea-hypopnea index (AHI). In this review article, we conducted a comprehensive literature search to assess the impact of acupuncture on obstructive sleep apnea. Our findings suggest that acupuncture may represent an effective and safe therapy option for individuals dealing with obstructive sleep apnea. Results: Acupuncture may also assist patients with obstructive sleep apnea in enhancing their oxygen saturation and improving their sleep quality. This discovery holds particular significance for individuals with moderate to severe obstructive sleep apnea. However, it is worth noting that methodological weaknesses in most of the trials in this field may overstate the clinical efficacy of acupuncture therapy. Conclusions: Further high-quality randomized clinical trials are warranted to establish the effectiveness and safety of acupuncture for obstructive sleep apnea patients.

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Effects of acupuncture on obstructive sleep apnea severity, blood pressure control and quality of life in patients with hypertension: A randomized controlled trial

Cited by 11 publications

References 24 publications

Effects of acupuncture on obstructive sleep apnea–hypopnea syndrome: A meta‐analysis

Effects of acupuncture on obstructive sleep apnea–hypopnea syndrome: A meta‐analysis

Acupuncture improves immunity and fatigue after chemotherapy in breast cancer patients by inhibiting the Leptin/AMPK signaling pathway

Efficacy of Acupuncture in the Treatment of Obstructive Sleep Apnea: A Review

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