EFFECTS OF ACUTE ALCOHOL INTOXICATION ON PITUITARY-GONADAL AXIS HORMONES, PITUITARY-ADRENAL AXIS HORMONES, beta-ENDORPHIN AND PROLACTIN IN HUMAN ADULTS OF BOTH SEXES

Frias, J.; Torres, Juan Antonio Vera; Miranda, Marı́a Isabel; Ruiz, Enrique Martínez; Ortega, Esperanza

doi:10.1093/alcalc/37.2.169

Cited by 89 publications

(65 citation statements)

References 27 publications

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“…While Frias et al (2000) reported that alcohol ingestion produced a decrease in plasma testosterone levels and no significant changes in either FSH or LH levels; Little et al (1992) demonstrated that administration of alcohol to prepubescent males stimulated testosterone secretion with no changes in serum LH. Furthermore, they stated that when alcohol was administered to adult male rats, both testosterone and LH levels decreased.…”

Section: Discussionmentioning

confidence: 99%

Influence of virgin coconut oil (VCNO) on oxidative stress, serum testosterone and gonadotropic hormones (FSH, LH) in chronic ethanol ingestion

Dosumu¹,

Duru²,

Osinubi³

et al. 2010

ABJNA

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The present study explored the effect of virgin coconut oil on oxidative stress, testosterone and gonadotropic hormones in alcohol-induced testicular injury. Twenty-five male rats were randomly assigned to one of five groups (n=5). The oil was processed from the mature endosperm of coconut and administered at 6.7 ml/kg body weight, while alcohol was given orally at 7 ml/kg body weight. After sacrifice, testicular malondialdehyde and serum hormone levels were determined. Testicular malondialdehyde levels increased significantly in animals treated with alcohol alone (p < 0.001), and animals treated with alcohol following virgin coconut oil treatment (p < 0.05) while the other groups showed a significant decrease (p < 0.05) when compared with the control. However, when compared with the group treated with alcohol alone, all the other groups showed a significant decrease (p < 0.05) in testicular malondialdehyde level. Serum testosterone levels increased significantly (p < 0.05) in rats treated with virgin coconut oil when compared with the alcohol-only treated group, while serum FSH and LH levels were not significantly different from the control values in all the treatment groups. Virgin coconut oil effectively lowered alcohol-induced oxidative stress by reducing testicular malondialdehyde levels and ameliorated the deleterious effect of alcohol on serum testosterone level, but showed no effect on serum FSH and LH levels.

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Section: Discussionmentioning

confidence: 99%

Influence of virgin coconut oil (VCNO) on oxidative stress, serum testosterone and gonadotropic hormones (FSH, LH) in chronic ethanol ingestion

Dosumu¹,

Duru²,

Osinubi³

et al. 2010

ABJNA

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“…Since the ovary is an important source of circulating progesterone and allopregnanolone in humans (Rapkin et al, 1997;Genazzani et al, 2002), the study included women in follicular (AAI, n ¼ 10; controls, n ¼ 7) or luteal (AAI, n ¼ 10; controls, n ¼ 8) phases of their ovarian cycle. Their consumption of alcohol was confirmed by the measurement of blood alcohol concentrations, using a gas-chromatographic head-space method described previously by our group (Frias et al, 2002). Statistically significant differences between the groups were analyzed by a two-way ANOVA.…”

Section: Methodsmentioning

confidence: 99%

Alcohol Intoxication Increases Allopregnanolone Levels in Female Adolescent Humans

Torres

Ortega

2003

Neuropsychopharmacol

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Teenage drinking is a cause of growing concern in industrialized countries, where almost 35% of alcohol drinkers are under 16 years old. Increased anxiety, irritability, and depression among adolescents may induce them to seek the anxiolytic and rewarding properties of alcohol. We studied the effects of acute alcohol intoxication (AAI) on the plasma levels of progesterone and allopregnanolone in female adolescents. Blood samples were drawn from female adolescents who arrived at the emergency department. One study group was formed by those who arrived with evident behavioral symptoms of AAI and the other by those arriving for mild trauma (contusions, sprains) after no consumption of alcohol (controls). Our results demonstrate that AAI significantly increases serum progesterone and allopregnanolone levels in both follicular and luteal phases of the ovarian cycle. Since alcohol and allopregnanolone positively modulate gamma-aminobutyric acid type A (GABA A ) receptors, allopregnanolone may play a major role in the anxiolytic and rewarding effects of alcohol, either directly or by influencing the sensitivity of GABA A -receptors to alcohol.

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“…Ethanol and its metabolite acetaldehyde have a direct toxic effect on Leydig cells but, on the other hand, there is a disruption on the hypothalamic-pituitary-gonadal axis. Chronic alcohol exposure decreases circulating LH levels and the response of LH to GnRH is reduced in alcoholics [5]. Disturbance of the hypothalamic-pituitary-gonadal axis persists over months of abstinence, with sustained increases in serum free and total testosterone levels in the presence of inadequate raised LH concentrations [2].…”

Section: Discussionmentioning

confidence: 99%

Total serum testosterone estimation and ultrasonographic volumetric evaluation of testes in patients with alcoholic liver cirrhosis

et al. 2009

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AbstractIn the course of cirrhosis, a variety of disturbances of endocrine glands occur. Degenerative changes in the testes with atrophia and fibrosis of the glandular tissue are often found in men. Twenty-one males with compensated alcoholic liver cirrhosis were studied. The age ranged from 29 to 61 years (mean 47,1). Efficiency of the liver was evaluated according to Child classification. HBC (this needs to be spelled out in parenthesis) or HBV (Hepatitis B Virus) infections were excluded. Levels of serum testosterone were determined and the volume size of the testes was measured using 7,5 MHz sector probe, B&K Medical ultrasonograph, 3535 model. Volume size of the testes was measured in 22 healthy control volunteers, as well; age ranged from 25 to 66 years (mean-46,6). All patients were interviewed about sexual function, particularly possible erectile dysfunction using IIEF-5 questionnaire. The mean testosterone level was 8,89 umol/l (ranged: 7,4–10,9 umol/l) in the study patients [the normal range interval: 8,2–34,6 umol/l]. The level was below the normal range in 4 patients, and low but within the normal range in the remaining patients. Statistically significant lower values of both testes volumes were estimated in patients with compensated alcoholic liver cirrhosis in comparison to healthy controls (p<0,001), however only 5 (23,81 %) study group subjects admitted impaired libido and erectile dysfunction. Decreased levels of testosterone in the peripheral blood and diminished volume size of testes are found in patients suffering from alcoholic liver cirrhosis. Erectile dysfunction in patients with liver cirrhosis needs further evaluation.

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EFFECTS OF ACUTE ALCOHOL INTOXICATION ON PITUITARY-GONADAL AXIS HORMONES, PITUITARY-ADRENAL AXIS HORMONES, beta-ENDORPHIN AND PROLACTIN IN HUMAN ADULTS OF BOTH SEXES

Cited by 89 publications

References 27 publications

Influence of virgin coconut oil (VCNO) on oxidative stress, serum testosterone and gonadotropic hormones (FSH, LH) in chronic ethanol ingestion

Influence of virgin coconut oil (VCNO) on oxidative stress, serum testosterone and gonadotropic hormones (FSH, LH) in chronic ethanol ingestion

Alcohol Intoxication Increases Allopregnanolone Levels in Female Adolescent Humans

Total serum testosterone estimation and ultrasonographic volumetric evaluation of testes in patients with alcoholic liver cirrhosis

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