Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals

Cooke, Molly; Iosia, Mike; Buford, Thomas W.; Shelmadine, Brian; Hudson, Geoffrey M.; Kerksick, Chad M.; Rasmussen, Christopher; Greenwood, Mike; Leutholtz, Brian; Willoughby, Darryn S.; Kreider, Richard B.

doi:10.1186/1550-2783-5-8

Cited by 116 publications

(95 citation statements)

References 42 publications

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“…In another study, serum MDA levels were also unaffected by treatment of CoQ 10 in trained cyclists (46). On the contrary, Cooke et al (47) stated that acute supplementation with CoQ 10 resulted in higher MDA levels during and following exercise. They indicated that acute and chronic supplementation of CoQ 10 may affect acute and/or chronic responses to various types of exercise.…”

Section: Discussionmentioning

confidence: 92%

Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart

Okudan¹,

Revan²,

Balcı³

et al. 2012

BLL

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This study examined the combined effects of swimming training and coenzyme Q 10 (CoQ 10 ) supplementation on exhaustive exercise-induced oxidative stress in rat heart. The study was carried out with 4-monthold young adult male Wistar rats. Sixty four rats were divided mainly into two groups: trained and control. Each group was further divided into four subgroups: rest, exhausted, rest with CoQ 10 , exhausted with CoQ 10 . The training program consisted of swimming one hour each day, fi ve days a week, for six weeks. At the end of sixth week, rats in exhausted exercise group were forced to swim until exhaustion and then they were immediately sacrifi ced, while rats in rest group were sacrifi ced at rest. Training alone or in combination with CoQ 10 supplementation reduced to increasing MDA levels due to exhaustive exercise in rat heart (p<0.05). The trained-rest with CoQ 10 group showed lower 8-OHdG levels than the control-rest with CoQ 10 group. Exhaustive exercise effect was signifi cant on SOD activity. Exhaustive exercise increased GSH levels in control groups while decreased GSH levels in training groups (p<0.05). In conclusion, the results suggest that CoQ 10 supplementation combined with training may inhibit lipid peroxidation and DNA damage in the heart tissue. Also, it can be said that SOD activity and GSH levels were not infl uenced by CoQ 10 supplementation (Fig. 4

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Section: Discussionmentioning

confidence: 92%

Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart

Okudan¹,

Revan²,

Balcı³

et al. 2012

BLL

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“…This fold increase resulted in increased CoQ10 in heart (11.3%), breast (45%), wings (25%) and legs (16%) of chicken. Cooke et al (2008) and Gopi et al (2014a) recorded an increase in muscle CoQ10 at 20 mg kgG 1 content with reduction in muscle cholesterol content but were not at 40 mg of CoQ10 kgG 1 of diet. Krizman et al (2012) also proposed that for production of functional food chicken, supplementation of CoQ10 could be considered in future as CoQ10 in Asian J.…”

Section: Coenzyme Q10 Absorption Among Body Tissuesmentioning

confidence: 99%

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

Gopi¹,

Kumar²,

Elaiyaraja³

et al. 2015

Asian J. of Animal and Veterinary Advances

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The essentiality of nutrients keeps on changing with the advancement in nutritional research and genetic gain. The genetic gain especially in poultry sector is very high which results in increase in nutrient requirement of both the essential and non-essential nutrients. For the rapid growth the requirement of essential nutrients reaches many folds which are in direct relation with the performance, but the requirement for non-essential nutrients is an indirect one. Most of the dispensable amino acids, vitamin C, carnitine, etc. which are being synthesized endogenously are now a days unable to meet the birds requirements that warrants the dietary supply. Another important nutrient is coenzyme Q10 (CoQ10) which endogenously synthesized is now gaining much attention as a supplement for fast growing broilers. The CoQ10 can be termed as multi-functionary as each and every cell in the body needs this but quantity is being high for very active organs like heart, lungs, liver, kidney, etc. They are essential for cellular oxidative phosphorylation and regenerative antioxidant. The supplementation of CoQ10 improved the feed efficiency with reducing the electron leaks from mitochondria and increases total antioxidant capacity. For this property, CoQ10 is widely used in human medicine especially persons suffering from cardiac, neurological disorder, hypercholesterolemic condition and also even in cancer. The CoQ10 in poultry draws first attention when it is found to reducing the ascites mortality in marketable broilers. Thereafter, the advantages of CoQ10 is started to exploit with much attention to ascites, feed efficiency, cholesterol lowering effect nutraceutical and nutrigenomic property both in poultry and swine industry.

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“…Acute and chronic supplementation of CoQ 10 may affect acute and/or chronic responses to various types of exercise [85,88]. CoQ 10 supplementation increased total CoQ concentration in the slow-twitch muscles and was useful for reducing exhaustive exercise-induced muscular injury by enhancing stabilization of muscle cell membrane [89].…”

Section: Ubiquinonesmentioning

confidence: 99%

Antioxidants and Their Importance During Muscular Exercise: A Review

Bjelakovic¹,

Kocić

Radovanović

et al. 2017

FU Med Biol

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Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals

Abstract: Background: To determine whether acute (single dose) and/or chronic (14-days) supplementation of CoQ10 will improve anaerobic and/or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations within trained and untrained individuals.

Cited by 116 publications

References 42 publications

Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart

Effects of CoQ10 supplementation and swimming training on exhaustive exercise-induced oxidative stress in rat heart

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

Antioxidants and Their Importance During Muscular Exercise: A Review

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