Effects of acute and chronic toluene inhalation on behavior and (3H)-serotonin binding in rat

Yamawaki, Shigeto; Segawa, Tomio; Sarai, Keisuke

doi:10.1016/0024-3205(82)90439-8

Cited by 34 publications

(13 citation statements)

References 12 publications

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“…Thinner is among the most abused solvents and toluene is its main component (2), and it is a psychotropic associated to the morbidity of this addiction (3). The inhalation of toluene vapors causes various psychotropic effects (4).…”

Section: Introductionmentioning

confidence: 99%

Effect of Toluene and Nutritional Status on Serotonin, Lipid Peroxidation Levels and NA+/K+-ATPase in Adult Rat Brain

et al. 2005

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The aim was to evaluate the effect of toluene and nutritional status on levels of serotonin (5-HT), 5-hydroxytryptophan (5-HTP), Na+/K+-ATPase, total ATPase and lipid peroxidation (TBARS) in rat brain. Study was conducted with malnourished (MN), well-nourished (WN) and normal Wistar rats. Three groups were formed for each nutritional status: control group I received 0.9% NaCl; toluene (1 g/kg) was administered to group II, and 1.5 g/kg to group III. Levels of 5-HT decreased (P< 0.05) in WN toluene groups, and 5-HTP decreased (P < 0.05) in the WN 1 g toluene and MN 1.5 g toluene groups. TBARS decreased (P < 0.05) in WN toluene groups. A trend to increase in Na+/K+-ATPase was found in WN and MN toluene groups, while total ATPase increased (P < 0.05) in the WN 1.5 g toluene group. The results suggest that high concentrations of toluene in single doses induce significant changes in the serotonergic system and alter membrane fluidity more perceptibly in the brain of adult animals with regular diet than in malnourished animals.

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Section: Introductionmentioning

confidence: 99%

Effect of Toluene and Nutritional Status on Serotonin, Lipid Peroxidation Levels and NA+/K+-ATPase in Adult Rat Brain

et al. 2005

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“…Several neurological deficits have been described in experimental animals following inhalation or intraperitoneal injection, including modified levels of enzymes (Korpela and Tahti, 1988), lipids (Kyrklund et al, 1987), and specific neurotransmitter receptors (Yamawaki et al, 1982;Von Euler et al, 1988). Behavioral and electroencephalic changes have also been reported (Naaslund, 1986;Rees et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Toluene-induced oxidative stress in several brain regions and other organs

Mattia

Ali

Bondy

1993

Molecular and Chemical Neuropathology

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“…Several studies have shown that short-term exposure to low concentrations of toluene (80-1000 ppm) can affect the levels and utilization of catecholamines, such as noradrenaline and dopamine [8][9][10][11][12][13][14][15][16]. The changes in catecholamine turnover may be related to changes in monoamine receptor binding [17][18][19][20][21]. Of the receptors hitherto tested, the dopamine D-2 receptors appear to be especially vulnerable to toluene exposure [20,21].…”

Section: Introductionmentioning

confidence: 99%

Subacute exposure to low concentrations of toluene affects dopamine-mediated locomotor activity in the rat

et al. 1991

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SummaryThe effects of low concentrations of toluene (4~80 ppm. 3 days. 6 h/day) were investigated on spontaneous and on apomorphine-induced locomotor activity in the rat. and were correlated to effects on S(-) [N-propyl-3 H(N)]-propylnorapomorphine ([ 3 H]NPA) binding in rat neostriatal membranes. on membrane fluidity. membrane leakage. and calcium levels in synaptosomes from the frontoparietal cortex, the neostriatum and the subcortical limbic area. and on serum hormone levels. Toluene exposure (80 ppm, post-exposure delay 18 h) alone did not affect locomotor activity, but attenuated apomorphineinduced (0.05 mg/kg, s.c.) suppression of rearing. and potentiated apomorphine-induced (I mg/kg. s.c.) increases in locomotion and rearing. Toluene exposure increased the K 0 value of [3H]NPA binding without affecting the Bmax· All these effects were absent at 40 ppm of toluene or at a post-exposure delay of 42 h. Toluene exposure (80 ppm. post-exposure delay of 18 h) did not affect the serum levels of prolactin. TSH, corticosterone. or aldosterone, or synaptosomal membrane fluidity and calcium levels. whereas membrane leakage was increased in the neostriatum. The present study indicates that the reduction of D-2 receptor affinity by short-term. low-dose toluene exposure is accompanied by a reduced D-2 autoreceptor function and an enhanced postsynaptic D-2 receptor function.

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Effects of acute and chronic toluene inhalation on behavior and (3H)-serotonin binding in rat

Cited by 34 publications

References 12 publications

Effect of Toluene and Nutritional Status on Serotonin, Lipid Peroxidation Levels and NA+/K+-ATPase in Adult Rat Brain

Effect of Toluene and Nutritional Status on Serotonin, Lipid Peroxidation Levels and NA+/K+-ATPase in Adult Rat Brain

Toluene-induced oxidative stress in several brain regions and other organs

Subacute exposure to low concentrations of toluene affects dopamine-mediated locomotor activity in the rat

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