Effects of acute and repeated alcohol ingestion on hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal functioning in normal males

Ida, Yoshishige; Tsujimaru, Shusaku; Nakamaura, Katsura; Shirao, Ishou; Mukasa, Hirokazu; Egami, Hideaki; Nakazawa, Yoichi

doi:10.1016/0376-8716(92)90009-2

Cited by 80 publications

(45 citation statements)

References 22 publications

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“…Animal studies on stimulated bladder muscle strips reported reduced contractility of the detrusor and urethra with acute administration of ethanol 20,21 , while studies on chronic exposure have shown both increased and decreased contractility of the detrusor muscle 22,23 . Acute alcohol consumption causes a transient decrease in circulating testosterone levels 24 , and an increase in circulating oestrogens in men 25 , and sex hormones have been shown to cause relaxation of certain smooth muscle types by suppressing calcium influx 26 . However, population studies on chronic moderate alcohol intake and testosterone concentration have reported conflicting results 27 .…”

Section: Discussionmentioning

confidence: 99%

The association of diet and other lifestyle factors with the onset of overactive bladder: a longitudinal study in men

Dallosso

Matthews

McGrother

et al. 2004

Public Health Nutr.

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Objective: To investigate associations between diet and non-dietary lifestyle factors and the onset of overactive bladder (OAB) in men. Subjects: Random sample of community-dwelling men aged 40 years plus. Design and methods: Baseline data on urinary symptoms and diet were collected from 5454 men using a postal questionnaire and a food-frequency questionnaire. Followup data on urinary symptoms were collected from 4887 men in a postal survey one year later. Logistic regression analysis was used to investigate diet and lifestyle factors associated with onset of OAB in the men without OAB at baseline. Results: There was a highly significant negative association between beer intake at baseline and subsequent OAB onset (P ¼ 0.001), with reduced risk at all levels of intake compared with those who seldom/never drank beer. Adjustment for total alcohol intake (g ethanol day -1 ) reduced the significance of the association (P ¼ 0.02). None of the food groups studied was associated with OAB onset, with the possible exception of potatoes (P ¼ 0.05), which showed an increased risk of onset at the highest level of consumption. Physical activity, smoking and obesity were not significantly associated. Conclusions: While most diet and lifestyle factors were not associated with OAB onset, the evidence from this prospective longitudinal study suggests that beer may have a protective role in the development of OAB. This could be due to a nonalcoholic ingredient as well as the alcohol content.

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Section: Discussionmentioning

confidence: 99%

The association of diet and other lifestyle factors with the onset of overactive bladder: a longitudinal study in men

Dallosso

Matthews

McGrother

et al. 2004

Public Health Nutr.

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“…The increase in PRL in these patients, however, was associated with increased androgen conversion to estradiol, possibly due to liver cirrhosis. Alcoholic men also showed elevated plasma levels of PRL [37][38][39]. Male alcoholic patients frequently show evidence of feminization that is manifested by gynecomastia, spider angiomata, palmar erythema and changes in body hair patterns [10]: a potential role for PRL and estradiol in the pathogenesis for the observed feminization.…”

Section: Cell Cycle Genomic Instability and Tumorigenesis In Lactotmentioning

confidence: 99%

Genesis of Prolactinomas: Studies Using Estrogen-Treated Animals

Sarkar

2006

Frontiers of Hormone Research

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Prolactin-secreting adenomas (prolactinomas) are the most prevalent form of pituitary tumors in humans. Our knowledge of the formation of these tumors is limited. Experimental work in animal has uncovered that estradiol exposure leads to prolactinoma formation via orchestrated events involving dopamine D2 receptors, transforming growth factor-β (TGF-β) isoforms and their receptors, as well as factors secondary to TGF-β action. Additionally, these studies determined that TGF-β and b-FGF interact to facilitate the communication between lactotropes and folliculo-stellate cells that is necessary for the mitogenic action of estradiol. The downstream signaling that governs lactotropic cell proliferation involves activation of the MAP kinase p44/42-dependent pathway.Pituitary tumors are primarily adenomas; they account for approximately 10-15% of intracranial tumors. They cause significant morbidity due to local invasion, hypopituitarism or hormone hypersecretion [1,2]. Pituitary tumors are classified as either functioning and secreting excessive amounts of active hormones, or as endocrinologically inactive and secreting no hormones or inactive hormones. Pituitary tumors are also classified by virtue of their size into the arbitrary division of those less than 1 cm as microadenomas and those more than 1 cm as macroadenomas. Pituitary tumors secreting excess prolactin are characterized as prolactinomas. Prolactinomas are the most frequently occurring neoplasm in the human pituitary [3,4]. In the general population, 1:2,800 men and 1:1,050 women are considered to have prolactinomas [5]. In human subjects, prolactinomas occur as both macroadenomas and microadenomas. In addition, mixed growth hormone and prolactin-secreting adenomas are documented to exist in a substantial number of acromegaly patients.Hyperprolactinoma is a condition in which plasma prolactin (PRL) levels are elevated above normal levels. Hyperprolactinemia, with elevation of serum prolactin of more than 200 ng/ml, is characteristically associated with prolactinomas [6]. Hyperprolactinemia causes reproductive dysfunction such as amenorrhea, galactorrhea, and infertility in women [7]. Amenorrhea and galactorrhea may occur alone or together [8]. Up to 25% of patients with secondary amenorrhea have been diagnosed with hyperprolactinemia. Many of these patients showed micro-prolactin adenomas or macro-prolactin adenomas in the pituitary. Although treatments that alter central dopaminergic neuronal functions cause an elevated serum PRL level, in most cases hyperprolactinemia is due to a pituitary tumor. In women, prolactinomas are mainly microadenomas. These microadenomas are rarely associated with hypopituitarism or central nervous system dysfunction. Idiopathic hyperprolactinemia, without demonstrable pituitary or hypothalamic disease, has also been identified. In men, prolactinomas are mainly

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“…Alguns trabalhos têm demonstrado uma maior ativação do eixo HHA após a ingestão aguda de álcool (0,8-1,75 g/kg) em indivíduos saudáveis (29,30), entretanto outros trabalhos não confirmaram esses achados (31). Esses dados são difíceis de serem comparados, já que diferem em duração da observa-…”

Section: Alcoolismounclassified

Estados de pseudo-Cushing

Romanholi

Salgado

2007

Arq Bras Endocrinol Metab

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Síndromes de pseudo-Cushing são um grupo heterogêneo de doenças, incluindo alcoolismo, anorexia nervosa, obesidade visceral e depressão, que compartilham muitas das características clínicas e bioquímicas da síndrome de Cushing. Os mecanismos responsáveis para a gênese da síndrome de pseudo-Cushing são fracamente compreendidos. Tem sido sugerido que o hipercortisolismo da síndrome de pseudo-Cushing pode ser resultante do aumento da secreção do hormônio liberador de corticotrofina (CRH) hipotalâmico no contexto de um eixo hipotálamo-hipofisário-adrenal que, de outra maneira, está normalmente constituído. A sobreposição substancial entre as características clínicas e laboratoriais entre muitos pacientes com síndrome de Cushing e aqueles com síndrome de pseudo-Cushing pode tornar o diagnóstico diferencial difícil. Distinguir entre síndrome de pseudo-Cushing e síndrome de Cushing verdadeira é crítico para se prevenir o tratamento desnecessário e potencialmente prejudicial de tais pacientes. Esta breve revisão sumariza os principais eventos patofisiológicos das síndromes de pseudo-Cushing e fornece uma estratégia útil para o seu diagnóstico diferencial.

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Effects of acute and repeated alcohol ingestion on hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal functioning in normal males

Cited by 80 publications

References 22 publications

The association of diet and other lifestyle factors with the onset of overactive bladder: a longitudinal study in men

The association of diet and other lifestyle factors with the onset of overactive bladder: a longitudinal study in men

Genesis of Prolactinomas: Studies Using Estrogen-Treated Animals

Estados de pseudo-Cushing

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