Effects of acute buspirone administration on inhibitory control and sexual discounting in cocaine users

Abstract

These findings indicate that acutely administered buspirone has little impact on behavioral measures of inhibitory control and impulsive sexual decision-making. Considering previous findings with chronic dosing, these findings highlight that the behavioral effects of buspirone differ as a function of dosing conditions.

The condom purchase task: A hypothetical demand method for evaluating sexual health decision‐making

“…Results here demonstrated that condom demand at unconstrained cost was sensitive to a contextual risk factor relevant for STI transmission such that condom demand increased as a function of increasing perceived partner STI risk. These findings parallel those of previous delay discounting studies that have demonstrated higher likelihoods of condom-protected sex when condoms are readily available (at no delay) for hypothetical sexual partners classified as being higher in STI risk Johnson & Bruner, 2012;Strickland, Bolin, Romanelli, Rush, & Stoops, 2017). These findings are also similar to the observation that condom use is more likely when the risk of transmission is made highly probable or certain in probability discounting tasks (Berry et al, 2019).…”

Buspirone maintenance does not alter the reinforcing, subjective, and cardiovascular effects of intranasal methamphetamine

“…These data are consistent with prior reports showing that the combination of buspirone with methamphetamine (Pike et al, 2016; Paterson et al, 2014) and cocaine (Bolin et al, 2016) is safe and tolerable. These findings are also concordant with a past study demonstrating that buspirone alone does not engender subjective effects (Strickland et al, 2017). …”

Does being drunk or high cause HIV sexual risk behavior? A systematic review of drug administration studies

“…These studies investigated acute effects of alcohol in samples that ranged from social or moderate drinkers (e.g., Davis et al, 2010; Jacques-Tiura et al, 2015) to heavy or heavy episodic-drinkers (e.g., Gilmore et al, 2013; Maisto et al, 2012), and across various populations at risk for HIV contraction including men who have sex with men (MSM one study; Maisto et al, 2012), heterosexual women (seventeen; or majority in sample were heterosexual e.g., Zawacki et al, 2011), heterosexual men (ten; e.g., Maisto et al, 2004), or heterosexual men and women (eleven; or majority of participants in sample were heterosexual; e.g., Johnson et al, 2016). The remaining studies focused on acute effects of cocaine administration among male and female cocaine users (Johnson et al, 2017, specific sexual orientation not required), THC administration among male and female regular cannabis users (one; Metrik et al, 2012, specific sexual orientation not required/specified), and buspirone maintenance or acute buspirone administration among male and female cocaine users (e.g., Bolin et al, 2016; Strickland et al, 2017; specific orientation not required). The majority of the studies were conducted in the U.S., and several were conducted in Canada (see Table 1).…”

“…Higher doses of buspirone, longer maintenance periods, and a counseling component may also help to maximize these initial promising findings (Bolin et al, 2016). Indeed, Strickland et al (2017) tested the effects of acute (rather than maintenance) buspirone using the Sexual Delay Discounting Task as described above, and found little effect on condom-protected versus unprotected sex.…”