Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep

Manconi, Mauro; Ferri, Raffaele; Zucconi, Marco; Clemens, Stefan; Rundo, Francesco; Oldani, Alessandro; Ferini‐Strambi, Luigi

doi:10.1016/j.sleep.2010.03.019

Cited by 95 publications

(83 citation statements)

References 47 publications

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“…Our result matches previous studies that analyzed HRV during sleep sequences without PLMS in subjects with RLS [11], confirming that the autonomic sympathovagal balance seems unaffected at rest condition.…”

Section: Tablesupporting

confidence: 92%

“…PLM during relaxed wakefulness (PLMW) index was 1.5 ± 2.1/h (range 0-7.1/h). At IRLS, two patients had very severe degree of disease (score 31-40), eight had severe degree (score 21-30) and the remaining two had moderate degree (score [11][12][13][14][15][16][17][18][19][20]. None of our patients had mild RLS (score 1-10).…”

Section: Demographic and Clinical Datamentioning

confidence: 90%

“…Moreover, the disinhibition of IML leads to an increase in sympathetic output that might explain the alteration of ANS observed by some authors [11,29]. In addition, there is wide evidence that the dopaminergic system dysfunction induces hypertension [30][31][32], as supported by experimental studies in dopamine D3 knockout mice that has been proposed as a potential animal model for RLS [33].…”

Section: Tablementioning

confidence: 98%

“…In the last decade, many authors focused on the potential consequences of RLS on cardio-and cerebrovascular diseases [6,7], sometimes by investigating the autonomic nervous system (ANS), mainly during sleep [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…However, some authors failed to find any association between RLS and hypertension and/or cardiovascular diseases [13,14]. Moreover, changes in sympatho-vagal balance in RLS patients with PLMS were observed during sleep by means of heart rate variability (HRV) spectral analysis [11].…”

Section: Introductionmentioning

confidence: 99%

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Is autonomic nervous system involved in restless legs syndrome during wakefulness?

et al. 2014

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A B S T R A C TObjective: To investigate cardiovascular autonomic function in patients with restless leg syndrome (RLS) by means of cardiovascular reflexes and heart rate variability (HRV) during wakefulness. Methods: Twelve RLS patients and 14 controls underwent cardiovascular function tests including headup tilt test (HUTT), Valsalva maneuver, deep breathing, hand grip, and cold face. HRV analysis was performed in the frequency domain using both autoregressive (AR) and fast Fourier transform algorithms in rest supine condition and during HUTT.Results: There was a significant increase in systolic blood pressure values in supine rest condition and a trend toward a lower Valsalva ratio in RLS patients with respect to controls. The significant and physiological changes of HRV at HUTT detected in healthy subjects were not found in RLS patients. Conclusion: RLS patients exhibit a tendency toward hypertension, reduced amplitude of both sympathetic and parasympathetic responses at HUTT, as well as blunted parasympathetic drive to blood pressure changes. These findings, if confirmed by more controlled studies, might support the hypothesis of autonomic nervous system involvement during wakefulness and consequently an enhanced cardiovascular risk in RLS.

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Section: Tablesupporting

confidence: 92%

Section: Demographic and Clinical Datamentioning

confidence: 90%

Section: Tablementioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is autonomic nervous system involved in restless legs syndrome during wakefulness?

et al. 2014

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Dissociation of periodic leg movements from arousals in restless legs syndrome

Manconi¹,

Ferri

Zucconi

et al. 2012

Annals of Neurology

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121

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Objective: The purpose of this study was to characterize the nature of the relation between periodic leg movements during sleep (PLMS) and cortical arousals to contribute to the debate on the clinical significance and treatment of PLMS. Methods: A prospective, placebo‐controlled, single‐blind, parallel group study was carried out including 46 drug‐naive patients with idiopathic restless legs syndrome (RLS). Each patient underwent 2 consecutive full‐night polysomnographic studies. The first night was the baseline night. Prior to the second night, 1 group received a single oral dose of 0.25mg pramipexole, whereas a second group received a single oral dose of 0.5mg clonazepam, and the remaining patients received placebo. Sleep stages, cyclic alternating pattern (CAP), and leg movement activity were scored following standard criteria; symptoms of RLS were also assessed. Results: Pramipexole suppressed PLMS without affecting electroencephalographic (EEG) instability (CAP) and arousals (corresponding to CAP A3 and, partially, A2 subtypes), whereas clonazepam did the opposite, reducing non‐rapid eye movement sleep EEG instability without effects on PLMS. Both drugs were effective on sensory RLS symptoms. Interpretation: This study demonstrates that a selective pharmacological approach can disconnect PLMS from arousal events, suggesting an indirect relation between each other. These results might weaken the hypothesis of a direct pathological role of PLMS in sleep disruption and can be important for the discussion on the existence of a distinct entity called periodic limb movements disorder. Moreover, the study opens the doors to the possibility of a joint treatment for RLS targeting sensory and motor symptoms, as well as sleep instability. ANN NEUROL 2012;71:834–844

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The double‐edged sword of the amoxicillin antibiotic against prostate cancer in nano palladium form and its electrochemical detection of dopamine

Hassan

Hanna

Medany

2023

Applied Organom Chemis

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Pd (II) complex was prepared from the interaction with Schiff base based on the condensation amoxicillin trihydrate drug and 4-N,N-dimethylaminobenzaldehyde. The complex was prepared on the nanoscale that was investigated using transmission electron microscopy (TEM). The chemical structure of the synthesized Schiff base and its Pd (II) chelate was proved through several techniques. Assays using MTT and lactate dehydrogenase verified the Pd (II) complex ability to inhibit human prostate cancer cells (PC3). According to the findings, the inhibition of PC3 cell growth was directly proportional to the dose of Pd (II) complex. Its highest IC 50 value was attained after 48 h of incubation reached to 22.6 μg/mL. As a measure of DNA damage in PC3 cells, this IC50 value demonstrated a significant increase in early and late apoptotic cells with an intense comet nucleus. Given that the concentration of reactive oxygen species (ROS) in treated PC3 cells was much higher than in control ones. These results contributed to the notion that ROS-mediated cell death, which may have taken place via the mitochondrial pathway, was the mechanism by which the Pd (II) complex inhibited the proliferation of PC3 cancer cells. The prepared Pd (II) complex was fabricated and casted onto GC electrode for investigate the dopamine concentration in human serum. The limit of detection and limit of quantization were found to be 0.0127 and 0.0424 μM, respectively, which were in a good agreement with literature and were found to be an improvement to that present in the literature.

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Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep

Cited by 95 publications

References 47 publications

Is autonomic nervous system involved in restless legs syndrome during wakefulness?

Is autonomic nervous system involved in restless legs syndrome during wakefulness?

Dissociation of periodic leg movements from arousals in restless legs syndrome

The double‐edged sword of the amoxicillin antibiotic against prostate cancer in nano palladium form and its electrochemical detection of dopamine

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