Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats

Motaghinejad, Majid; Motevalian, Manijeh; Shabab, Behnaz; Fatima, Sulail

doi:10.1007/s00702-016-1623-5

Cited by 30 publications

(15 citation statements)

References 51 publications

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“…Furthermore, an increase in oxidative stress was shown with acute and chronic MPH treatment in the SHR [ 78 ]. Finally, acute administration of high doses of MPH in adult rats produced oxidative damage, reduced GSH, SOD, GPx, and glutathione reductase (GR) activities, and provoked neurodegeneration in the cerebral cortex and hippocampus [ 79 ]. Recently, in the cortex and hippocampus of rats treated with MPH, MDA levels were increased and SOD levels reduced [ 81 ].…”

Section: Role Of Oxidative Stressmentioning

confidence: 99%

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Corona

2020

Antioxidants

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder of childhood. Although abnormalities in several brain regions and disturbances of the catecholaminergic pathway have been demonstrated, the pathophysiology of ADHD is not completely understood, but as a multifactorial disorder, has been associated with an increase in oxidative stress and neuroinflammation. This review presents an overview of factors that increase oxidative stress and neuroinflammation. The imbalance between oxidants and antioxidants and also the treatment with medications are two factors that can increase oxidative damage, whereas the comorbidity between ADHD and inflammatory disorders, altered immune response, genetic and environmental associations, and polymorphisms in inflammatory-related genes can increase neuroinflammation. Evidence of an association with these factors has become valuable for research on ADHD. Such evidence opens up new intervention routes for the use of natural products as antioxidants that could have potential as a treatment against oxidative stress and neuroinflammation in ADHD.

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Section: Role Of Oxidative Stressmentioning

confidence: 99%

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Corona

2020

Antioxidants

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“…One study showed that acute and chronic treatment with MPH in the SHR model increased oxidative stress [136]. Finally, the acute administration of high doses of MPH can cause oxidative and inflammatory changes in brain cells and induce neurodegeneration in the hippocampus and cerebral cortex of adult rats [137].…”

Section: Oxidative Stress and The Relationship With Adhdmentioning

confidence: 99%

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

et al. 2020

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Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked with an increased risk of substance use and side effects. The pathophysiology of ADHD is not completely known, although it has been associated with an increase in inflammation and oxidative stress. This review presents an overview of findings following antioxidant treatment for ADHD and describes the potential amelioration of inflammation and oxidative stress using antioxidants that might have a future as multi-target adjuvant therapy in ADHD. The use of antioxidants against inflammation and oxidative conditions is an emerging field in the management of several neurodegenerative and neuropsychiatric disorders. Thus, antioxidants could be promising as an adjuvant ADHD therapy.

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“…Accordingly, elevation of NO production together with increased ROS might not only have positive effects, as peroxynitrite is an extremely potent oxidative species [59]. In fact, it was shown that MPH triggers ROS production in various animal studies [60,61]. By contrast, a clinical study points to protective effects of MPH against oxidative stress, at least after 12 weeks of MPH medication [62].…”

Section: Blood Pressure In Pediatric Adhd and Potential Effects Of Mphmentioning

confidence: 99%

Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate

Jansen

Hanusch

Pross

et al. 2020

JCM

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Attention deficit hyperactivity disorder (ADHD) is a common pediatric psychiatric disorder, frequently treated with methylphenidate (MPH). Recently, MPH’s cardiovascular safety has been questioned by observational studies describing an increased cardiovascular risk in adults and blood pressure alterations in children. We considered members of the L-arginine (Arg)/nitric oxide (NO) pathway as possible early cardiovascular risk factors in pediatric ADHD children. They include the NO metabolites, nitrite and nitrate, the NO precursor Arg, and asymmetric dimethylarginine (ADMA), an endogenous NO synthase (NOS) inhibitor and a cardiovascular risk factor in adults. We conducted a prospective clinical trial with 42 ADHD children (aged 6–16 years) with (n = 19) and without (n = 23) MPH treatment. Age-matched children without ADHD (n = 43) served as controls. All plasma and urine metabolites were determined by gas chromatography-mass spectrometry. We observed higher plasma nitrite and lower plasma ADMA concentrations in the ADHD children. MPH-treated ADHD children had higher plasma nitrite concentrations than MPH-untreated ADHD children. As NOS activity is basally inhibited by ADMA, MPH treatment seems to have decreased the inhibitory potency of ADMA. Percentiles of systolic blood pressure were higher in MPH-treated ADHD children. The underlying mechanisms and their implications in the MPH therapy of pediatric ADHD with MPH remain to be elucidated in larger cohorts.

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Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats

Cited by 30 publications

References 51 publications

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate

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