Effects of Acute Exercise and Chronic Exercise on the Liver Leptin-AMPK-ACC Signaling Pathway in Rats with Type 2 Diabetes

Yi, Xuejie; Cao, Shicheng; Bo, Chang; Zhao, Dan; Gao, Haining; Wan, Yihan; Jiaojiao, Shi; Wei, Wei; Guan, Yifu

doi:10.1155/2013/946432

Cited by 36 publications

(26 citation statements)

References 52 publications

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“…(237^9 mg/dl) [19], and Otsuko LongEvans Tokushima Fatty (222^6 mg/dl) rat models [20]. The study also showed that in agreement with earlier studies [13], placement of Plexiglass clips on renal arteries led to renal hypertension 4 weeks after the operation.…”

Section: Isolated Aortic Studysupporting

confidence: 87%

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

Nekooeian

Khalili

Khosravi

2014

Journal of Asian Natural Products Research

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The mechanism of oleuropein's antihypertensive effects was examined in rat model of simultaneous type 2 diabetes and renal hypertension (diabetic hypertensive). Five groups of male Sprague-Dawley rats including a control, a diabetic-hypertensive group receiving vehicle, and three diabetic-hypertensive groups receiving oleuropein at 20, 40, or 60 mg/kg/day were used. The duration of diabetes was 10 weeks; during the last 4 weeks of which, animals were hypertensive and received vehicle or oleuropein. Systolic blood pressure, glucose and malondialdehyde, heart rate, and maximal response to phenylephrine (PE) in the absence of nitro-L-arginine methyl ester (L-NAME) of oleuropein-treated groups were significantly lower than those of vehicle-treated group. Erythrocyte superoxide dismutase, maximal response to PE in the presence of L-NAME, and maximal response to acetylcholine (Ach) of oleuropein-treated groups were significantly higher than those of vehicle-treated group. The findings indicate that antihypertensive effects of oleuropein might be partly mediated by improving the release of nitric oxide, and antioxidant and sympathoplegic activities.

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Section: Isolated Aortic Studysupporting

confidence: 87%

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

Nekooeian

Khalili

Khosravi

2014

Journal of Asian Natural Products Research

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“…These data suggest that a single bout of exercise does not affect hepatic gluconeogenesis either in mice fed with CD or HFD. This is in contrast with results from other studies in rodents . Knudsen et al .…”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, they observed that phosphorylation of ACC and AMPK decreased immediately after exercise, suggesting that β‐oxidation is not a major contributor to energy production in the liver. This is in agreement with another recent study showing decreased AMPK phosphorylation in rat liver in response to acute exercise . As it is clear that proteins show a differential expression according the intensity of exercise, the time elapsed after exercise, and the presence of diabetes, we speculate that the intensity of our exercise bout was insufficient to induce a transcriptional response in non‐insulin resistant mice.…”

Section: Discussionsupporting

confidence: 93%

Hepatic gene expression in mouse models of non‐alcoholic fatty liver disease after acute exercise

Piguet

Guarino

Potaczek

et al. 2019

Hepatology Research

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Aim Non‐alcoholic fatty liver disease (NAFLD) patients benefit from physical exercise. This study aimed to investigate the effect of acute exercise on hepatic gene expression in different mouse models of NAFLD. Methods C57BL/6J mice were fed with a control (CD) or a high fat (HFD) diet. AlbCrePtenflox/flox (Pten‐KO) and Fxr−/− mice, two genetic models of NAFLD with insulin hypersensitivity and resistance, respectively, were fed with CD. After 4 weeks, mice were randomly assigned to exercise or sedentariness. Mice were killed 15 min or 3 h after the running/sedentary period. Genome‐wide hepatic gene expression was evaluated with the Illumina Micro‐array platform. Quantitative polymerase chain reaction confirmed changes in gene expression. Results Acute exercise transiently affected the expression of genes involved in the immune response in C57BL/6 mice fed with CD and this effect normalized in the recovery phase. Acute exercise affected genes involved in gluconeogenesis in the insulin resistant Fxr−/− model. Genes involved in lipid metabolism were affected in C57BL/6 mice fed with CD, but not in mouse models of NAFLD. Genes involved in DNA damage response pathways were deregulated only in C57BL/6 mice fed with CD and not in mouse models of NAFLD. Conclusion The simultaneous analysis of different NAFLD models revealed that an acute exercise bout affects hepatic gene expression differentially according to animal models and that most of the differentially expressed genes are involved in glucose and fatty acid metabolism, immune regulation, and DNA damage response.

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“…Zhao et al (2011) demonstrated improvements in hypothalamic leptin signaling in rats submitted to chronic exercise. In the same line of thought, Yi et al (2013) showed an increase in leptin receptors on liver and vascular smooth muscle. Other studies proposed mechanisms related with reduction on fat pad mass (Estadella et al, 2004;Park et al, 2012).…”

Section: Discussionmentioning

confidence: 69%

7-week aerobic exercise training reduces adipocyte area and improves insulin sensitivity in Wistar rats fed a highly palatable diet

Garcia

Silva

Ferreira

et al. 2016

Motriz: rev. educ. fis.

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Abstract--The aim of this study was to evaluate the effect aerobic exercise training on fat pad mass, adipocyte size, leptin release and insulin sensitivity in rats fed with high fat-palatable diet. Twenty-four male Wistar rats (250-260g) were divided into four groups: sedentary control (CTR/SD), trained control (CTR/TR), obese sedentary (OB/SD) and obese trained (OB/TR). Obese groups were fed with high fat-palatable diet (27% of fat) and control groups fed with AIN-93. Our results showed that aerobic exercise training was effective to reduce body weight and epididymal fat mass in CTR/TR and OB/TR. Insulin and glucose levels were increased in OB/TR compared with OB/SD. Aerobic exercise training reduced the average area of adipocytes in CTR/TR and OB/TR and it was associated with reduced plasma insulin and leptin. In conclusion, 7-week aerobic exercise training reduces adipocyte area and improves insulin sensitivity and leptin levels in high fat-palatable diet-fed Wistar rats.

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Effects of Acute Exercise and Chronic Exercise on the Liver Leptin-AMPK-ACC Signaling Pathway in Rats with Type 2 Diabetes

Cited by 36 publications

References 52 publications

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

Hepatic gene expression in mouse models of non‐alcoholic fatty liver disease after acute exercise

7-week aerobic exercise training reduces adipocyte area and improves insulin sensitivity in Wistar rats fed a highly palatable diet

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