Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats

Chagas, Marcos Hortes Nisihara; Crippa, José Alexandre de Souza; Zuardi, Antônio Waldo; Hallak, Jaime Eduardo Cecílio; Machado‐de‐Sousa, João Paulo; Hirotsu, Camila; Maia, Lucas O.; Tufik, Sérgio; Andersen, Mônica Levy

doi:10.1177/0269881112474524

Cited by 73 publications

(44 citation statements)

References 26 publications

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“…Concerning the effects of CBD on sleep, animal studies have found different results according to the dose and route of administration used . The intracerebroventricular administration of CBD led to an increase in wakefulness and consequent reduction in REM sleep in rats .…”

Section: What Is New and Conclusionmentioning

confidence: 99%

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

et al. 2014

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Section: What Is New and Conclusionmentioning

confidence: 99%

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

et al. 2014

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“…For instance, Monti (1977) found a diminution in sleep after systemic administration of CBD [10], whereas Carlini and Cunha (1981) showed an improvement in sleep in insomniacs after using CBD [11]. Moreover, systemic administration of CBD (10 or 40 mg/kg) in male Wistar rats during the light period, enhanced the total percentage of sleep [12]. Further complexity has been added to the understanding of CBD pharmacology since Nicholson et al .…”

Section: Modulation Of Sleep-wake Cycle By Cannabidiolmentioning

confidence: 99%

Potential Effects of Cannabidiol as a Wake-Promoting Agent

Murillo-Rodrı́guez¹,

Sarro-Ramírez²,

Sánchez³

et al. 2014

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Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased. Most attention has focused on ∆9-tetrahydrocannabinol (∆9-THC) as it is the psychoactive constituent of Cannabis sativa (C. sativa). However, in previous years, the focus of interest in the second plant constituent with non-psychotropic properties, cannabidiol (CBD) has been enhanced. Recently, several groups have investigated the pharmacological properties of CBD with significant findings; furthermore, this compound has raised promising pharmacological properties as a wake-inducing drug. In the current review, we will provide experimental evidence regarding the potential role of CBD as a wake-inducing drug.

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“…However, other studies have demonstrated a reduction in REM sleep following THC administration (21–23). Similarly, while in some cases CBD has demonstrated hypnotic properties (24, 25), it has alternatively been associated with increased wakefulness (26). Furthermore, chronic cannabis users exhibit decreased SWS compared to controls immediately following termination of use, with recovery after fours weeks of abstinence (27).…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent cannabis use, depressive symptoms, andFAAHgenotype predict sleep quality in emerging adults: a pilot study

Maple

McDaniel

Shollenbarger

et al. 2016

The American Journal of Drug and Alcohol Abuse

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Background Cannabis has been shown to affect sleep in humans. Findings from animal studies indicate that higher endocannabinoid levels promote sleep, suggesting that chronic use of cannabis, which downregulates endocannabinoid activity, may disrupt sleep. Objectives This study sought to determine if past year cannabis use and genes that regulate endocannabinoid signaling, FAAH rs324420 and CNR1 rs2180619, predicted sleep quality. As depression has been previously associated with both cannabis and sleep, the secondary aim was to determine if depressive symptoms moderated or mediated these relationships. Methods Data were collected from 41 emerging adult (ages 18–25) cannabis users. Exclusion criteria included Axis I disorders (besides SUD) and medical and neurologic disorders. Relationships were tested using multiple regressions, controlling for demographic variables, past year substance use, and length of cannabis abstinence. Results Greater past year cannabis use and FAAH C/C genotype were associated with poorer sleep quality. CNR1 genotype did not significantly predict sleep quality. Depressive symptoms moderated the relationship between cannabis use and sleep at a non-significant trend level, such that participants with the greatest cannabis use and most depressive symptoms reported the most impaired sleep. Depressive symptoms mediated the relationship between FAAH genotype and sleep quality. Conclusions This study demonstrates a dose-dependent relationship between chronic cannabis use and reported sleep quality, independent of abstinence length. Furthermore, it provides novel evidence that depressive symptoms mediate the relationship between FAAH genotype and sleep quality in humans. These findings suggest potential targets to impact sleep disruptions in cannabis users.

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Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats

Abstract: The systemic acute administration of CBD appears to increase total sleep time, in addition to increasing sleep latency in the light period of the day of administration.

Cited by 73 publications

References 26 publications

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

Potential Effects of Cannabidiol as a Wake-Promoting Agent

Dose-dependent cannabis use, depressive symptoms, andFAAHgenotype predict sleep quality in emerging adults: a pilot study

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