Effects of acute topiramate dosing on open field behavior in mice

Abstract

Although topiramate (TPM) has been used to treat human disease, there are few studies of its effects on the behavior of animal models. Objective. This study aimed to assess the effect of acute TPM administration on the behavior of mice undergoing the open-field test. Method. The animals were divided in two groups: the treatment group (n = 10), which received 10 mg/kg TPM intraperitoneally, and the control group (n = 10), which received saline. 30 minutes after drug administration, the animals were assessed for 5 minutes in the open-field. The following parameters were analyzed: number of squares explored, immobility time, central area permanence time, peripheral apparatus permanence time, rearing frequency and time, grooming frequency and time, rearing frequency during the last minute, number of fecal boli, and estimated speed. Results. The treatment group had a higher number of squares explored (p = 0.02) and greater estimated speed (p = 0.01). Conclusion. The results suggest that acute TPM administration increases the locomotor activity of mice without interfering with learning, anxiety, stress, and exploratory behavior.

Topiramato

“…Nesta edição da Revista Neurociências temos o prazer de contar com um estudo experimental de Bertges et al, da Universidade Federal de Juiz de Fora (MG), com o objetivo principal de avaliar o efeito da administração aguda do topiramato no comportamento exploratório de camundongos em campo aberto. Os autores evidenciaram que a administração aguda do topiramato aumentou a atividade locomotora destes animais 4 .…”