Effects of Adjuvant-Induced Inflammation on Disposition of Diclofenac and Its Metabolites in Perfused Rat Liver

Uraki, Misato; Kawase, Atsushi; Sayama, Hiroyuki; Matsushima, Yuta; Iwaki, Masaya

doi:10.1016/j.xphs.2016.12.021

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…The decrease in RBC, Hb and increase in WBC by DCF-Potassium was previously reported [11]. The decrease in blood parameters caused by this drug may be attributed to its harmful effects on bone marrow and haematopoietic organs [12,13]. The Hb, PCV and MCV levels all showed varying alterations ( Table 5).…”

Section: Discussionmentioning

confidence: 56%

“…The platelets levels was lowest at low concentration of DCF but became highest at high dose. This indicates that although DCF is an anti-inflammatory drug at low dose at high concentration it has negative effect at very high concentration by inducing inflammatory process [13,14]. This is evident from the elevated levels of the WBC & PLT in all the dichlofenac treatment groups.…”

Section: Discussionmentioning

confidence: 83%

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Evaluation of Diclofenac (DCF) Potassium as a Possible Predisposer of Benign Prostatic Hyperplasia in Wistar Albino Rats

Zaruwa¹,

Muhammad²,

Abdullahi³

et al. 2020

SJBR

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 83%

Evaluation of Diclofenac (DCF) Potassium as a Possible Predisposer of Benign Prostatic Hyperplasia in Wistar Albino Rats

Zaruwa¹,

Muhammad²,

Abdullahi³

et al. 2020

SJBR

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“…This is possibly because inflammatory states (rheumatoid arthritis, etc.) delay the elimination of drug metabolites via reduction of biliary excretion [13] .…”

Section: Assessmentmentioning

confidence: 99%

Diclofenac-Induced Post Infantile Giant Cell Hepatitis

Venkataraman

Mohan

Conyers

et al. 2018

Journal of Gastroenterology and Hepatology Research

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unknown quantity of garlic tablets. Workup for hepatitis including infectious and toxic etiologies were ruled out. Serum IgG levels were elevated with increased globuin gap, and positive ANA titer of 640, anti-smooth muscle cell antibodies elevated at 41 units (moderate to strong positive > 30 units). Liver biopsy demonstrated submassive necrosis in the setting of post-infantile giant cell hepatitis. The differential diagnoses included idiopathic autoimmune hepatitis, viral or drug induced injury. Our diagnosis was drug induced autoimmune liver disease (DIALD), the etiology is likely due to Diclofenac given temporal relationship of drug intake and symptom onset, as well as a calculated Roussel Uclaf Causality Assessment Method (RUCAM) score of 6, signifying probable drug-induced liver disease. Patient was started on Prednisone and Azathioprine with complete resolution of clinical and laboratory findings within 5 months. DISCUSSION: The outcome of PIGCH is unpredictable, usually adopts a fulminant course leading to cirrhosis within months, however, a more benign course has also been described. PIGCH is triggered by three primary etiologies: drugs, infection, and autoimmune liver injury. This case highlights that giant cell hepatitis is a multifactorial condition that can be precipitated by drug use in the setting of autoimmune phenotype. Garlic and garlic extracts, through their antioxidant activities, have been reported to provide protection against free radical damage in the body. The innocuous course of PIGCH in our patient could possibly be due to concurrent consumption of garlic tablets. Further research is needed in this area.

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Changes in Radixin Expression and Interaction with Efflux Transporters in the Liver of Adjuvant-Induced Arthritic Rats

et al. 2019

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Effects of Adjuvant-Induced Inflammation on Disposition of Diclofenac and Its Metabolites in Perfused Rat Liver

Cited by 4 publications

References 45 publications

Evaluation of Diclofenac (DCF) Potassium as a Possible Predisposer of Benign Prostatic Hyperplasia in Wistar Albino Rats

Evaluation of Diclofenac (DCF) Potassium as a Possible Predisposer of Benign Prostatic Hyperplasia in Wistar Albino Rats

Diclofenac-Induced Post Infantile Giant Cell Hepatitis

Changes in Radixin Expression and Interaction with Efflux Transporters in the Liver of Adjuvant-Induced Arthritic Rats

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