Effects of Adrenergic Drugs Administered During Ovum Transport and Chemical Sympathectomy of the Oviduct on Fertility in Rabbits1

Hodgson, Barrie J.; Fremming, Benjamin D.; Daly, Susan

doi:10.1095/biolreprod13.2.142

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…Other studies indicated little or no effect of such drugs (Paton et al, 1978). When effects have been seen they are generally small and could be due to non-specific actions of the experimental procedure (Hodgson, Fremming & Daly, 1975).…”

Section: Discussionmentioning

confidence: 99%

Pregnancy and parturition in rats after sympathetic denervation of the ovary, oviduct and utero-tubal junction

Roche¹,

Parkington²,

Gibson³

1985

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The ovarian vascular pedicle and ovarian suspensory ligament were briefly frozen to destroy the nerves. Examination of sections from the ovary, oviduct and utero-tubal junction by fluorescence histochemistry showed that they were usually devoid of adrenergic nerves. Measurement of noradrenaline in segments of the uterine horn by high-performance liquid chromatography showed that the transmitter was eliminated from the upper third but not the middle or lower thirds of the uterine horn. Unilateral or bilateral denervations at metoestrus in cyclic rats did not affect either the number of ovulations or the numbers or spacing of conceptuses at Day 7 of pregnancy. Bilateral denervations on Days 4, 7 or 11 of pregnancy did not affect ovarian weights or numbers of conceptuses observed 1 week later. Plasma progesterone concentrations were at least as high in the denervated groups as in the sham-operated control groups. After unilateral or bilateral denervations at Day 15, pregnancy continued normally and birth of normal young occurred, without apparent problems, at the same time as for sham-operated rats. The mothers tended their young and allowed them to suck. It is concluded that the adrenergic innervation of the ovary in the rat is not required for its normal function during pregnancy; that of the oviduct and mesosalpinx is not required for ovum pick-up or for transport of oocytes, spermatozoa or early embryos; and that of the utero-tubal junction is not required for uterine motility involved in embryo spacing and parturition.

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Section: Discussionmentioning

confidence: 99%

Pregnancy and parturition in rats after sympathetic denervation of the ovary, oviduct and utero-tubal junction

Roche¹,

Parkington²,

Gibson³

1985

Reproduction

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show abstract

“…The timing of this 'unlocking' of the isthmus coincides with the cyclic hormonal change from oestrogen (follicular) to progestagen (luteal) dominance. The once popular theory that this hormone-dependent unlocking was mediated through /i-adrenoceptors (Brundin, 1969) has recently been challenged on the basis of pharmacological interference with adrenergic nerve function (Johns, Chlumecky, Cottle & Paton, 1975;Hodgson, Fremming & Daly, 1975 The extensibility of the rat cervix was measured by a modification (Figure 1) of the method of Harkness & Harkness (1959). The removable stainless steel pins (P1 and P2; diameter 1.5 mm) were placed through the lumina of the cervix (c).…”

Section: ~~~~~~~~~~~0mentioning

confidence: 99%

Proceedings of the British Pharmacological Society

1977

British J Pharmacology

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Systemic Pharmacology of Adrenergic Activators and Inhibitors: Effects on the Genital System

M¹,

Kovács²

1981

Adrenergic Activators and Inhibitors

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Effects of Adrenergic Drugs Administered During Ovum Transport and Chemical Sympathectomy of the Oviduct on Fertility in Rabbits1

Cited by 8 publications

References 20 publications

Pregnancy and parturition in rats after sympathetic denervation of the ovary, oviduct and utero-tubal junction

Pregnancy and parturition in rats after sympathetic denervation of the ovary, oviduct and utero-tubal junction

Proceedings of the British Pharmacological Society

Systemic Pharmacology of Adrenergic Activators and Inhibitors: Effects on the Genital System

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