Effects of Adrenocorticotropic Hormone (ACTH) and of Cortisone on Peptic Ulcer

Sandweiss, David J.

doi:10.1016/s0016-5085(19)36102-5

Cited by 73 publications

(7 citation statements)

References 27 publications

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“…As far back as 1950 it was noted on the base of clinical observations that it needs at least 5-7 days of corticosteroids use before appearance of ulcer symptoms (Sandweiss, 1954). One of the principles for minimizing undesirable side effects of glucocorticoid therapy is "keep treatment as short as possible, since treatment lasting 5 to 7 days shows fewer side effect" (Longui, 2007).…”

Section: Discussionmentioning

confidence: 99%

Dual action of glucocorticoid hormones on the gastric mucosa: how the gastroprotective action can be transformed to the ulcerogenic one

et al. 2009

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Glucocorticoid hormones have dual action on the stomach: gastroprotective and ulcerogenic one. The present study was designed to investigate how physiological gastroprotective action of glucocorticoids can be transformed to pathological ulcerogenic effect. Dose- and time-dependent effects of single injection of dexamethasone on indomethacin-induced gastric erosions, corticosterone and blood glucose levels, somatic parameters were investigated in rats. Dexamethasone at the doses of 0.1, 1, 10 mg/kg decreased the gastric erosion area dose dependently in the case of its injection 1 h before indomethacin administration. Gastroprotective action of dexamethasone (at a dose of 1 mg/kg) was also observed in the case of its injection 6 and 12 h before indomethacin. However, the further increase in the time interval caused transformation of gastroprotective action of dexamethasone to ulcerogenic one. Accordingly to the data obtained short-term maintenance of blood glucose level provides the gastroprotective action of dexamethasone, while dexamethasone-induced long-lasting maintenance of blood glucose level accompanied with the signs of catabolic effects may be responsible at least partly for its ulcerogenic effect.

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Section: Discussionmentioning

confidence: 99%

Dual action of glucocorticoid hormones on the gastric mucosa: how the gastroprotective action can be transformed to the ulcerogenic one

et al. 2009

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“…According to the widely held view, glucocorticoids released during stress enhance the vulnerability of the stomach to stress action. This point of view has been based on the clinical and experimental data (Gray et al, 1953;Sandweiss, 1954;Black, 1988;Weusten et al, 1993) demonstrating the ulcerogenic properties of high doses of exogenous glucocorticoids and also on a positive correlation between stress-induced glucocorticoid level and gastric ulceration (Weiss, 1971;Murphy et al, 1979).…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic-pituitary-adrenocortical axis: the hidden gold in gastric mucosal homeostasis

et al. 2006

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The results overviewed in the present article suggest that glucocorticoids released during acute activation of hypothalamic-pituitary-adrenocortical (HPA) axis are important gastroprotective factors, allowing us to re-evaluate the traditional point of view about their ulcerogenic role. It has been shown that various ulcerogenic stimuli induce an increase in glucocorticoid production that in turn helps the gastric mucosa to resist against a harmful action of ulcerogenic stimuli. Glucocorticoids released in response to mild stress contribute to adaptive gastric cytoprotection. The gastroprotective action of glucocorticoids is accounted for by maintaining the local defensive factors and inhibiting the pathogenic elements. Maintenance of glucose and temperature homeostasis as well as systemic blood pressure by glucocorticoid hormones could be a fundamental of their beneficial action on various gastric targets. Thus, glucocorticoids released during activation of HPA axis may contribute to the gastric mucosal homeostasis through their contribution to general body homeostasis.

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“…In recent years it has become apparent that adrenocortical hormones are capable of influencing gastric secretory activity. The use of these steroids in therapeutics is frequently associated with the reactivation of peptic ulcer, and sometimes with the more dangerous consequences of hkemorrhage and perforation [Sandweiss, 1954]. It is well known that changes in adrenocortical activity, or the administration of adrenocortical hormones or their analogues are associated with changes in the concentration of sodium, chloride and potassium in body fluids such as serum, urine, saliva and sweat, and changes might therefore be anticipated in the concentration or output of these ions in gastric juice under similar circumstances.…”

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confidence: 99%

The Electrolyte Concentration of Human Gastric Secretion

1960

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The secretion by the stomach of hydrochloric acid, sodium, potassium and chloride has bepn studied in normal human subjects and in patients suffering from peptic ulcer.A close inverse relationship was demonstrated between the concentration of acid and sodium, and a direct relationship between potassium concentration and the rate of secretion of gastric juice. It is suggested that H and Na ions may share a secretory pathway, and that K concentration represents a part of the process of water secretion. These findings were consistent in over 300 samples of gastric juice, obtained without stimulation, and after stimulation with histamine or insulin.

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Effects of Adrenocorticotropic Hormone (ACTH) and of Cortisone on Peptic Ulcer

Cited by 73 publications

References 27 publications

Dual action of glucocorticoid hormones on the gastric mucosa: how the gastroprotective action can be transformed to the ulcerogenic one

Dual action of glucocorticoid hormones on the gastric mucosa: how the gastroprotective action can be transformed to the ulcerogenic one

Hypothalamic-pituitary-adrenocortical axis: the hidden gold in gastric mucosal homeostasis

The Electrolyte Concentration of Human Gastric Secretion

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