Effects of Aerobic Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in Stroke: A Systematic Review

Limaye, Neeraj S; Carvalho, Leonardo César; Kramer, Sharon

doi:10.1016/j.apmr.2021.04.010

Cited by 18 publications

(15 citation statements)

References 52 publications

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“…Previous literature about the effect of exercise on BDNF, IGF-1, and VEGF expression is heterogeneous and discussed to be dependent on exercise protocols, e. g. exercise type, intensity, volume (30,35,40,69,(74)(75)(76) as well as the level of physical tness (30,77). Consequently, moderate exercise intensity and increasing level of tness in the present study might have contributed to the missing increase in basal BDNF and VEGF concentration.…”

Section: Neurotrophic and Growth Factorsmentioning

confidence: 67%

“…VEGF has been shown to play a role in exercise-induced adult hippocampal neurogenesis and cognitive improvements (for review : 35). Despite controversial ndings in the literature, human studies and reviews provide consistent evidence that aerobic exercise enhances these neurotrophic and growth factors (35)(36)(37)(38)(39)(40). In previous investigations, decreasing BDNF and increasing IGF-1 level was found during isolation with regular exercise, whereas non-isolated and non-exercising control participants during 60 days of bedrest with or without arti cial gravity exposure did not show any changes (11,41).…”

mentioning

confidence: 86%

“…On the contrary to the ndings by Saucedo Marquez et al (83) and Santos et al (75), no difference in BDNF level between exercise protocols could be observed here. High-intensity interval exercise in the previous studies might have contributed to this discrepancy (40,75,83). Here, exercise intensity was aimed to be matched for both protocols for average treadmill speed.…”

Section: Neurotrophic and Growth Factorsmentioning

confidence: 99%

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Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement

Abeln

Fomina

Popova

et al. 2022

Preprint

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Exercise could prevent physical and psychological deteriorations, especially during pandemic times of lock-down scenarios and social isolation. But to meet both, the common exercise protocols require optimization based on holistic investigations and with respect to underlying processes. This study aimed to clarify individual chronic and acute effects of continuous and interval running exercise on physical and cognitive performance, mood, and affect and to explore underlying neurophysiological factors during a terrestrial simulated space mission.Six volunteers (three females) were isolated for 120 days. Accompanying exercise training consisted of continuous and interval running protocol a cross-over design. Incremental stage tests on a treadmill were done frequently to test physical performance. Actigraphy was used to monitor physical activity level. Cognitive performance, mood (MoodMeter®), affect (PANAS), brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), vascular-endothelial growth factor (VEGF), and saliva cortisol were investigated prior to, four times during, and after isolation, pre- and post-exercise on two separate days, respectively. As a chronic effect, physical performance increased (and IGF-1 tended) in the course of isolation and training until the end of isolation. Subjective mood and affect state, as well as cognitive performance, basal BDNF and VEGF levels, were well-preserved across the intervention. No acute effects of exercise were detected, besides slower reaction time after exercise in two out of nine cognitive tests, testing sensorimotor speed and memory of complex figures. Consistently higher basal IGF-1 concentrations and faster reaction time in the psychomotor vigilance test were found for the continuous compared to the interval running protocol. CONCLUSION: The results suggest that 120 days of isolation and confinement can be undergone without cognitive and mental deteriorations. Regular, individual exercise training is hypothesized to play an important role in this regard. Continuous running exercise seems to trigger higher IGF-1 levels and vigilance compared to interval running. Systematic and prolonged investigations and larger sample size are required to follow up on exercise-protocol specific differences in order to optimize the exercise intervention for long-term psycho-physiological health and well-being.

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Section: Neurotrophic and Growth Factorsmentioning

confidence: 67%

mentioning

confidence: 86%

Section: Neurotrophic and Growth Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement

Abeln

Fomina

Popova

et al. 2022

Preprint

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“…Furthermore, physical activity interventions have the potential to improve functional recovery after stroke. Limaye et al conducted a systematic review examining the effect of aerobic exercise interventions on serum biomarkers of neuroplasticity in human stroke survivors ( 150 ). The authors included nine studies, and found that aerobic interventions can increase brain-derived neurotrophic factors, insulin-like growth factor 1, and VEGF.…”

Section: Discussionmentioning

confidence: 99%

“…The authors included nine studies, and found that aerobic interventions can increase brain-derived neurotrophic factors, insulin-like growth factor 1, and VEGF. However, further investigation is needed to discern how these serum biomarkers of neuroplasticity are associated with collateral circulation, the optimal exercise type and dose, most appropriate timing to commence physical activity interventions after stroke (i.e., how early), and the effect on functional recovery across different phases (i.e., acute, subacute and chronic) post-stroke in humans ( 148 , 150 ).…”

Section: Discussionmentioning

confidence: 99%

Pre-stroke Physical Activity and Cerebral Collateral Circulation in Ischemic Stroke: A Potential Therapeutic Relationship?

et al. 2022

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Favorable cerebral collateral circulation contributes to hindering penumbral tissue from progressing to infarction and is associated with positive clinical outcomes after stroke. Given its clinical importance, improving cerebral collateral circulation is considered a therapeutic target to reduce burden after stroke. We provide a hypothesis-generating discussion on the potential association between pre-stroke physical activity and cerebral collateral circulation in ischemic stroke. The recruitment of cerebral collaterals in acute ischemic stroke may depend on anatomical variations, capacity of collateral vessels to vasodilate, and individual risk factors. Physical activity is associated with improved cerebral endothelial and vascular function related to vasodilation and angiogenic adaptations, and risk reduction in individual risk factors. More research is needed to understand association between cerebral collateral circulation and physical activity. A presentation of different methodological considerations for measuring cerebral collateral circulation and pre-stroke physical activity in the context of acute ischemic stroke is included. Opportunities for future research into cerebral collateral circulation, physical activity, and stroke recovery is presented.

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Combined Aerobic Exercise and Virtual Reality-Based Upper Extremity Rehabilitation Intervention for Chronic Stroke: Feasibility and Preliminary Effects on Physical Function and Quality of Life

Ross¹,

Hart²,

Williams³

et al. 2023

Archives of Rehabilitation Research and Clinical Translation

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Effects of Aerobic Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in Stroke: A Systematic Review

Cited by 18 publications

References 52 publications

Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement

Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement

Pre-stroke Physical Activity and Cerebral Collateral Circulation in Ischemic Stroke: A Potential Therapeutic Relationship?

Combined Aerobic Exercise and Virtual Reality-Based Upper Extremity Rehabilitation Intervention for Chronic Stroke: Feasibility and Preliminary Effects on Physical Function and Quality of Life

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