Effects of aerobic exercise on tear secretion and tear film stability in dry eye patients

Sun, Chao; Chen, Xiaofan; Huang, Yanming; Zou, Huan; Fan, Wenting; Yang, Mei; Yuan, Rongdi

doi:10.1186/s12886-021-02230-9

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…A prospective cross-sectional study involving 43 healthy participants found significant reductions in tear fluid levels of inflammation-related cytokine, including interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-4, IL-5, and dozens of others, after a 20 min exercise session in comparison to the baseline levels (38). More excitingly, exercise reduced the tear fluid concentration of the marker of oxidative stress, 8-hydroxy-2′-deoxyguanosine (8-OHdG), suggesting that exercise may play a role in alleviating DED by reducing the oxidative stress present in tears (39) (see Table 1).…”

Section: Potential Mechanismsmentioning

confidence: 99%

Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

Zhang,

Jiang,

Deng

et al. 2024

Front. Med.

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In the field of eye health, the profound impact of exercise and physical activity on various ocular diseases has become a focal point of attention. This review summarizes and elucidates the positive effects of exercise and physical activities on common ocular diseases, including dry eye disease (DED), cataracts, myopia, glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD). It also catalogues and offers exercise recommendations based on the varying impacts that different types and intensities of physical activities may have on specific eye conditions. Beyond correlations, this review also compiles potential mechanisms through which exercise and physical activity beneficially affect eye health. From mitigating ocular oxidative stress and inflammatory responses, reducing intraocular pressure, enhancing mitochondrial function, to promoting ocular blood circulation and the release of protective factors, the complex biological effects triggered by exercise and physical activities reveal their substantial potential in preventing and even assisting in the treatment of ocular diseases. This review aims not only to foster awareness and appreciation for how exercise and physical activity can improve eye health but also to serve as a catalyst for further exploration into the specific mechanisms and key targets through which exercise impacts ocular health. Such inquiries are crucial for advancing innovative strategies for the treatment of eye diseases, thereby holding significant implications for the development of new therapeutic approaches.

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Section: Potential Mechanismsmentioning

confidence: 99%

Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

Zhang,

Jiang,

Deng

et al. 2024

Front. Med.

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“…to promote tear secretion and improves tear lm stability in dry eye patients, 50,53 and tear lm instability has been linked to LWE. 28 Other studies have also demonstrated a link between a lack of exercise (i.e., sedentary lifestyle) and risk of DE.…”

Section: Discussionmentioning

confidence: 99%

“…Sedentary behavior has been associated with reduced tear breakup time, lower tear volume, and risk of DE. [50][51][52][53] It has been speculated that exercise increases parasympathetic stimulation of the lacrimal gland and acinar blood vessels, increasing secretion of electrolytes and aqueous. 1 Approximately 2.5 hours more per week spent outdoors was found to be a heavily weighted predictor of lesser corneal staining extent, and of lower CLDEQ-8 score among contact lens wearers.…”

Section: Discussionmentioning

confidence: 99%

Artificial Intelligence Models Utilize Lifestyle Factors to Predict Dry Eye-Related Outcomes

Graham,

Wang,

Kothapalli

et al. 2024

Preprint

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Purpose To examine and interpret machine learning models that predict dry eye (DE)-related clinical signs, subjective symptoms, and clinician diagnoses by heavily weighting lifestyle factors in the predictions. Methods Machine learning models were trained to take clinical assessments of the ocular surface, eyelids, and tear film, combined with symptom scores from validated questionnaire instruments for DE and clinician diagnoses of ocular surface diseases, and perform a classification into DE-related outcome categories. Outcomes are presented for which the data-driven algorithm identified subject characteristics, lifestyle, behaviors, or environmental exposures as heavily weighted predictors. Models were assessed by 5-fold cross-validation accuracy and class-wise statistics of the predictors. Results Age was a heavily weighted factor in predictions of eyelid notching, Line of Marx anterior displacement, and fluorescein tear breakup time (FTBUT), as well as visual analog scale symptom ratings and a clinician diagnosis of blepharitis. Comfortable contact lens wearing time was heavily weighted in predictions of DE symptom ratings. Time spent in near work, alcohol consumption, exercise, and time spent outdoors were heavily weighted predictors for several ocular signs and symptoms. Exposure to airplane cabin environments and driving a car were predictors of DE-related symptoms but not clinical signs. Prediction accuracies for DE-related symptoms ranged from 60.7–86.5%, for diagnoses from 73.7–80.1%, and for clinical signs from 66.9–98.7%. Conclusions The results emphasize the importance of lifestyle, subject, and environmental characteristics in the etiology of ocular surface disease. Lifestyle factors should be taken into account in clinical research and care to a far greater extent than has been the case to date.

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“…The Mediterranean diet has also been shown to be beneficial in systemic metabolic diseases and cardiovascular disorders [ 38 ]. It has also been confirmed that aerobic exercise promotes tear production and improves tear film stability in patients with DED [ 39 ]. Determining whether the prevention and control of diseases can be achieved through rational improvement of dietary patterns and healthy lifestyles is therefore significant and deserves long-term studies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associated risk factors of dry eye disease in Hotan, Xinjiang: a cross-sectional study

Li,

Wang,

et al. 2023

BMC Ophthalmol

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Objectives To assess the prevalence of dry eye disease (DED) in the Uyghur population in Hotan, Xinjiang, and to identify risk factors associated with this disorder. Methods Between January and September of 2020, 5,121 Uyghur subjects aged 18 − 98 years from 105 villages were selected and studied cross-sectionally using a whole-group random sampling method in the Hotan area, Xinjiang, China. The Ocular Surface Disease Index questionnaire was used to collect subjective symptoms of DED and examine tear-film break-up times. The break up time and Schirmer’s test were used to collect objective signs, to determine the prevalence of DED and its risk factors. Results A total of 5,121 subjects aged 18 − 98 years were recruited from the Uyghur population in the Hotan region of Xinjiang, China, for eye examinations and questionnaire surveys. A total of 40.6% (2,078/5,121) were diagnosed with DED, of which 38.3% were male and 41.9% were female. The prevalence of DED was the highest in subjects ≥ 65 years of age, with 47.8% in males and 53.3% in females. The lowest occurrence was in subjects 18 − 44 years of age, with 32.5% in males and 33.7% in females. Older age, tea drinking, and staying awake late were risk factors affecting the severity of DED prevalence (p < 0.05), but there was no significant difference in sex, presence of diabetes, or presence of hypertension (p > 0.05). Conclusion The prevalence of DED in the study population was 40.6%, and its prevalence was higher in females, when compared with males. The prevalence of dry eye also increased with age, and at an advanced age, female sex, smoking, staying awake late, and not exercising were risk factors for DED.

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Effects of aerobic exercise on tear secretion and tear film stability in dry eye patients

Cited by 7 publications

References 32 publications

Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

Artificial Intelligence Models Utilize Lifestyle Factors to Predict Dry Eye-Related Outcomes

Prevalence and associated risk factors of dry eye disease in Hotan, Xinjiang: a cross-sectional study

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