Effects of aerobic exercise on fibroblast growth factor 21 in overweight and obesity. A systematic review

Porflitt-Rodríguez, María; Guzmán-Arriagada, Valentina; Sandoval-Valderrama, Romina; Tam, Charmaine S.; Pavicic, Francisca; Ehrenfeld, Pamela; Martinez-Huenchullan, Sergio F.

doi:10.1016/j.metabol.2022.155137

Cited by 21 publications

(14 citation statements)

References 46 publications

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“…Our results suggest that the phosphorylation of AMPK stimulates energy homeostasis via activation of PPARα and FGF21, which subsequently increases lipolysis and FAO [34,56]. According to a systemic review that analyzed the results of nine clinical trials, chronic aerobic exercise training tends to decrease the level of FGF21 mRNA, and protein while increasing FGFR and KLB [57]. Our data and clinical results provide strong evidence that FGF21 sensitivity contributes to the preventive effects of aerobic exercise in metabolism.…”

Section: Discussionmentioning

confidence: 52%

Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice

Kim

et al. 2022

Metabolism

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Section: Discussionmentioning

confidence: 52%

Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice

Kim

et al. 2022

Metabolism

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“…As an important endocrine regulator with hormonal effects predominantly expressed in the liver [ 48 ], FGF21 contributes to ketogenesis and ameliorates obesity [ 49 , 50 ]. FGF21 is also one of the exercise-induced hepatokine, and exercise could improve lipid metabolism by affecting the expression level and activity of FGF21 [ 51 , 52 ]. Considered an upstream regulator of FGF21, PPARα could induce hepatic FGF21 expression in rats [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice

Yan

Ren

et al. 2023

Nutrients

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Obesity is a serious public health issue worldwide. Growing evidence demonstrates the efficacy of the ketogenic diet (KD) for weight loss, but there may be some adverse side effects such as dyslipidemia and hepatic steatosis. Aerobic exercise is a widely recognized approach for improving these metabolic markers. Here we explored the combined impacts of KD and moderate aerobic exercise for an 8-week intervention on body weight and fat loss, serum biomarkers, and hepatic lipid metabolism in a mouse model of high-fat diet-induced obesity. Both KD and KD combined with exercise significantly reduced body weight and fat mass. No significant adverse effects of KD were observed in serum biomarkers or hepatic lipid storage, except for an increase in circulating triglyceride level. However, aerobic exercise lowered serum triglyceride levels, and further ameliorated serum parameters, and hepatic steatosis in KD-fed mice. Moreover, gene and protein expression analysis indicated that KD combined with exercise was associated with increased expression of lipolysis-related genes and protein levels, and reduced expression of lipogenic genes relative to KD without exercise. Overall, our findings for mice indicate that further work on humans might reveal that KD combined with moderate aerobic exercise could be a promising therapeutic strategy for obesity.

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“…This hormone contributes to body weight regulation and is strongly involved in the response to nutritional deprivation and the ketogenic state in mice [ 39 ]. A systematic review of clinical studies exploring the effect of exercise on FGF21 levels concluded that acute exercise tended to increase circulatory levels of FGF21, while chronic exercise with a duration over 4 weeks had rather the opposite effect [ 40 ]. It was also described that higher levels of daily physical activity could decrease circulating FGF21 levels [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Different Effects of Cyclical Ketogenic vs. Nutritionally Balanced Reduction Diet on Serum Concentrations of Myokines in Healthy Young Males Undergoing Combined Resistance/Aerobic Training

et al. 2023

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Myokines represent important regulators of muscle metabolism. Our study aimed to explore the effects of a cyclical ketogenic reduction diet (CKD) vs. a nutritionally balanced reduction diet (RD) combined with regular resistance/aerobic training in healthy young males on serum concentrations of myokines and their potential role in changes in physical fitness. Twenty-five subjects undergoing regular resistance/aerobic training were randomized to the CKD (n = 13) or RD (n = 12) groups. Anthropometric and spiroergometric parameters, muscle strength, biochemical parameters, and serum concentrations of myokines and cytokines were assessed at baseline and after 8 weeks of intervention. Both diets reduced body weight, body fat, and BMI. Muscle strength and endurance performance were improved only by RD. Increased musclin (32.9 pg/mL vs. 74.5 pg/mL, p = 0.028) and decreased osteonectin levels (562 pg/mL vs. 511 pg/mL, p = 0.023) were observed in RD but not in the CKD group. In contrast, decreased levels of FGF21 (181 pg/mL vs. 86.4 pg/mL, p = 0.003) were found in the CKD group only. Other tested myokines and cytokines were not significantly affected by the intervention. Our data suggest that changes in systemic osteonectin and musclin levels could contribute to improved muscle strength and endurance performance and partially explain the differential effects of CKD and RD on physical fitness.

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Effects of aerobic exercise on fibroblast growth factor 21 in overweight and obesity. A systematic review

Cited by 21 publications

References 46 publications

Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice

Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice

Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice

Different Effects of Cyclical Ketogenic vs. Nutritionally Balanced Reduction Diet on Serum Concentrations of Myokines in Healthy Young Males Undergoing Combined Resistance/Aerobic Training

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