Effects of Aerobic Training on Airway Inflammation in Asthmatic Patients

Abstract

aerobic training reduces sputum eosinophil and FeNO in patients with moderate or severe asthma, and these benefits were more significant in subjects with higher levels of inflammation. These results suggest that aerobic training might be useful as an adjuvant therapy in asthmatic patients under optimized medical treatment.

Has Aerobic Exercise Anti-inflammatory Effect for Asthma?

“…More recently, an excellent study from Mendes et al demonstrated for the first time that 12 weeks of moderate intensity aerobic exercise in moderate and severe asthmatic patients resulted in decreased number of eosinophils in induced sputum, proving the concept that aerobic exercise presents anti-inflammatory effects for asthma [14].…”

“…This gradual change of concept represent a big advance against old paradigms, and is based in a growing number of clinical and experimental studies showing that the regular practice of aerobic exercises in appropriate volume and intensity results in several physical and psychological beneficial effects to asthmatic patients [5][6][7][8][9][10][11][12][13][14][15].…”

“…increase in ventilatory capacity) and asthmarelated symptoms "asthma-control" (e.g. dyspnea, exercise-induced bronchospasm or peak expiratory flow variability) [5][6][7][8][9][10][11][12][13][14][15]. In addition a decrease of daily use of inhaled steroids has been reported, suggesting an anti-inflammatory effect of exercise on asthmatic lungs [5][6][7][8][9][10][11][12][13][14][15].…”

“…dyspnea, exercise-induced bronchospasm or peak expiratory flow variability) [5][6][7][8][9][10][11][12][13][14][15]. In addition a decrease of daily use of inhaled steroids has been reported, suggesting an anti-inflammatory effect of exercise on asthmatic lungs [5][6][7][8][9][10][11][12][13][14][15]. This hypothesis was further supported by recent findings from Gonçalves et al and Mendes et al, demonstrating that aerobic exercise decreased the levels of exhaled nitric oxide, an established pro-inflammatory mediator in asthma, and also the number of eosinophils in induced sputum in moderate/severe persistent asthmatic patients [13,14].…”

Comparação entre exercício aeróbio e respiratório no controle clínico e inflamação pulmonar de pacientes com asma persistente moderada ou grave: ensaio clínico aleatorizado

“…As evidências na literatura têm demonstrado que os exercícios aeróbios podem proporcionar aos pacientes: melhora dos fatores relacionados à qualidade de vida 34,24,35 e do controle clínico 36 , bem como redução do número de crises e uso da medicação de alívio 37,24,35 , do broncoespasmo induzido pelo exercício 34 , da hiperresponsividade das vias aéreas 38 , do uso de corticosteróide 34 , do risco de exacerbação da asma 27,24,39 . Atualmente, tem-se sugerido que o exercício físico tenha um efeito antiinflamatório na asma evidenciado pela redução da fração de óxido nítrico exalado (FeNO) 39,40 e redução na porcentagem de eosinófilos no escarro 39 . Apesar desses estudos, os únicos benefícios amplamente reconhecidos do treinamento físico aeróbio em pacientes asmáticos, avaliados por análise sistemática, são o aumento da capacidade aeróbica, melhora dos fatores de saúde relacionados a qualidade de vida e redução da dispneia durante o exercício 22 .…”