Effects of age and age-related hearing loss on the neural representation of speech cues

Tremblay, Kelly L.; Piskosz, Michael; Souza, Pamela E.

doi:10.1016/s1388-2457(03)00114-7

Cited by 317 publications

(278 citation statements)

References 87 publications

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“…Similarly, hearing loss can affect N1 and P2 response latencies and amplitudes (Oates et al, 2002;Tremblay et al, 2003). In the current study, audiometric thresholds for all subjects were within the normal range through 4000 Hz and were closely matched for younger and older subjects at 500 Hz and 3000 Hz.…”

Section: Associations Among Cortical Potentials Audiometric Thresholsupporting

confidence: 61%

Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials

Harris

Mills

et al. 2008

Hearing Research

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Section: Associations Among Cortical Potentials Audiometric Thresholsupporting

confidence: 61%

Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials

Harris

Mills

et al. 2008

Hearing Research

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“…It remains unclear why different cortical evoked potential patterns are seen with synthetic versus natural speech. Similar onset rise times are seen for both types of stimuli, yet prolonged N100's (or double peaks) are seen with longer VOTs in synthetic speech (Elangovan and Stuart, 2011;Frye et al, 2007;Hoonhorst et al, 2009;Tremblay et al, 2003a; and no latency changes with natural speech (current study and Tremblay et al, 2003b). Tremblay et al, 2003b suggested that these differences could be attributed to stimulus characteristic differences.…”

Section: Consonants In Initial Positionsupporting

confidence: 57%

“…In contrast, other studies using synthetic speech described N100 latency to become delayed (Tremblay et al, 2003a;Frye et al, 2007) . Note that for onset responses (top traces) the amplitude of N100 is larger for /d/ than /t/ (FCz and GFP) with no differences in P200.…”

Section: Consonants In Initial Positionmentioning

confidence: 63%

Auditory cortical activity in normal hearing subjects to consonant vowels presented in quiet and in noise

Dimitrijevic

Pratt

Starr

2013

Clinical Neurophysiology

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“…Among listeners with matched thresholds, the actual amplitudes of the ABR waves are significantly lower with age (Boettcher et al 1993;Konrad-Martin et al 2012). Human studies using FFRs have found changes in neural timing and precision with age (Tremblay et al 2002(Tremblay et al , 2003Clinard et al 2010;Anderson et al 2012;Clinard and Tremblay 2013). Changes with age have also been observed at the level of single neurons in terms of decreased temporal coding and changes in rate coding in the dorsal cochlear nuclei (Schatteman et al 2008), inferior colliculus (IC) (Walton et al 1998;Palombi et al 2001;Walton et al 2002;Walton 2010;Rabang et al 2012), and auditory cortex (Mendelson and Ricketts 2001) and at a population level using EFRs in rodent aging models (Parthasarathy et al 2010;Parthasarathy and Bartlett 2011;Parthasarathy and Bartlett 2012).…”

Section: Introductionmentioning

confidence: 99%

Age-Related Changes in the Relationship Between Auditory Brainstem Responses and Envelope-Following Responses

Parthasarathy

Datta

Torres

et al. 2014

JARO

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Hearing thresholds and wave amplitudes measured using auditory brainstem responses (ABRs) to brief sounds are the predominantly used clinical measures to objectively assess auditory function. However, frequency-following responses (FFRs) to tonal carriers and to the modulation envelope (envelope-following responses or EFRs) to longer and spectro-temporally modulated stimuli are rapidly gaining prominence as a measure of complex sound processing in the brainstem and midbrain. In spite of numerous studies reporting changes in hearing thresholds, ABR wave amplitudes, and the FFRs and EFRs under neurodegenerative conditions, including aging, the relationships between these metrics are not clearly understood. In this study, the relationships between ABR thresholds, ABR wave amplitudes, and EFRs are explored in a rodent model of aging. ABRs to broadband click stimuli and EFRs to sinusoidally amplitude-modulated noise carriers were measured in young (3-6 months) and aged (22-25 months) Fischer-344 rats. ABR thresholds and amplitudes of the different waves as well as phase-locking amplitudes of EFRs were calculated. Age-related differences were observed in all these measures, primarily as increases in ABR thresholds and decreases in ABR wave amplitudes and EFR phaselocking capacity. There were no observed correlations between the ABR thresholds and the ABR wave amplitudes. Significant correlations between the EFR amplitudes and ABR wave amplitudes were observed across a range of modulation frequencies in the young. However, no such significant correlations were found in the aged. The aged click ABR amplitudes were found to be lower than would be predicted using a linear regression model of the young, suggesting altered gain mechanisms in the relationship between ABRs and FFRs with age. These results suggest that ABR thresholds, ABR wave amplitudes, and EFRs measure complementary aspects of overlapping neurophysiological processes and the relationships between these measurements changes asymmetrically with age. Hence, measuring all three metrics provides a more complete assessment of auditory function, especially under pathological conditions like aging.

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Effects of age and age-related hearing loss on the neural representation of speech cues

Cited by 317 publications

References 87 publications

Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials

Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials

Auditory cortical activity in normal hearing subjects to consonant vowels presented in quiet and in noise

Age-Related Changes in the Relationship Between Auditory Brainstem Responses and Envelope-Following Responses

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