2008
DOI: 10.1016/j.bbr.2008.05.023
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Effects of age and anxiety on learning and memory

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Cited by 73 publications
(26 citation statements)
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“…Physiologically, the impairments are associated with deficits in glutamatergic, GABAergic, dopaminergic, cholinergic and serotonergic neurotransmitter systems. Serotonergic neurotransmitter system contribute to the deficit through its influence on dopaminergic, cholinergic, glutamatergic, GABAergic and growth factors and receptor functions all important in schizophrenia and cognitive status (Gray and Roth 2007;Millan 2000;Küçük et al 2008;Mora et al 1997;Zhou et al 2008;Bantick et al 2001). Additional studies are required to determine the specific neural mechanisms responsible for the observed patterns on learning and memory.…”
Section: Discussionmentioning
confidence: 95%
“…Physiologically, the impairments are associated with deficits in glutamatergic, GABAergic, dopaminergic, cholinergic and serotonergic neurotransmitter systems. Serotonergic neurotransmitter system contribute to the deficit through its influence on dopaminergic, cholinergic, glutamatergic, GABAergic and growth factors and receptor functions all important in schizophrenia and cognitive status (Gray and Roth 2007;Millan 2000;Küçük et al 2008;Mora et al 1997;Zhou et al 2008;Bantick et al 2001). Additional studies are required to determine the specific neural mechanisms responsible for the observed patterns on learning and memory.…”
Section: Discussionmentioning
confidence: 95%
“…Cognitive functions were assayed in the MWM test. This test allows to evaluate learning ability and memory of rodents in spatial memory disorders (Brandeis et al, 1989;Moghaddam and Bures, 1997) and in aging (Joseph et al, 1999;Kiray et al, 2006;Küç ük et al, 2008). Several studies have suggested that old-aged rats exhibit reduced spatial memory in the MWM as compared to young rats, whereas young and middle-aged animals do not differ from each other (Blalock et al, 2003).…”
Section: Discussionmentioning
confidence: 97%
“…The MWM has been used extensively to measure cognitive deficits in spatial memory in lesion studies [40,41] and in aging [1,3,42,43]. It is known that old rats show reduced spatial memory on this test compared to young rats, while young and middle-aged animals do not differ from each other [44].…”
Section: Discussionmentioning
confidence: 99%