Effects of age and binarising area on choroidal vascularity index in healthy eyes: an optical coherence tomography study

Koçak, Nurullah; Subaşı, Mustafa; Yeter, Volkan

doi:10.1007/s10792-020-01636-6

Cited by 23 publications

(15 citation statements)

References 35 publications

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“…The universal mean values for SFCT and CVI in our study were slightly greater than the corresponding values in healthy eyes (SFCT, 306.05 ± 55.34 µm; CVI, 66.71% ± 2.58%) (24). In contrast, Lee et al (25) reported that the mean SFCTs of PSD were 428.5 ± 57.9 µm and 430.5 ± 68.1 µm using both spectral domain and swept source (SS) OCT, respectively, which were greater than the findings in our study.…”

Section: Discussioncontrasting

confidence: 81%

“…Because CVI is reportedly significantly correlated with pachyvessels ( 27 ), both the diameter ( 28 ) and area of choroidal hyporeflective lumina considerably contribute to SFCT, whereas choroidal stroma do not ( 29 ). Koçak et al ( 24 ) reported that SFCT was significantly greater in participants aged ≤18 years than in participants aged >18 years. However, our participants were considerably older; this increased age may have led to stromal atrophy and vascular arteriosclerosis in the choroid, thus resulting in lower SFCT.…”

Section: Discussionmentioning

confidence: 99%

“…However, our participants were considerably older; this increased age may have led to stromal atrophy and vascular arteriosclerosis in the choroid, thus resulting in lower SFCT. Furthermore, CVI was reportedly significantly greater in participants aged ≤ 18 years than in participants aged >18 years ( 24 ). However, we found no relationship between CVI and age.…”

Section: Discussionmentioning

confidence: 99%

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Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases

Hua

Zhang

2022

Front. Med.

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BackgroundThis study qualitatively and quantitatively compared imaging characteristics between neovascular and atrophic pachychoroid spectrum disease (PSD) by optical coherence tomography (OCT), and OCT angiography (OCTA).MethodsThe subtypes of PSD were identified by multi-modality imaging approaches. Subfoveal choroidal thickness (SFCT), choroidal vascular index (CVI), and vascular density of choroidal neovascularization (CNV) were measured.ResultsThe CVI and SFCT of 174 PSD eyes were 67.6% ± 5.48% and 362.2 ± 131.88 μm, respectively. After adjustment for age, linear regression indicated that SFCT was positively associated with CVI (p < 0.001), and patched hyper-reflective lesions in choriocapillaris layers (p = 0.009). Compared with neovascular PSD eyes, atrophic PSD eyes had similar patient age (57.1 ± 16.72 years, p = 0.639), SFCT (332.0 ± 111.00 μm, p = 0.51), and CVI (67.6% ± 3.94%, p = 0.527). There were no differences between polypoidal choroidal vasculopathy (PCV) eyes with aneurysmal polypoidal lesions and PCV eyes with tangled polypoidal lesions in terms of age, CVI, SFCT, vascular density, or the occurrence of double layer signs (DLSs, all p > 0.05). Logistic regression indicated that age (p = 0.003), SFCT (p = 0.003), patched hyper-reflective lesions in choriocapillaris layers (p = 0.009), and DLSs (p < 0.001) were predictive factors for CNV progression in PSD eyes (all p < 0.05).ConclusionsOur study highlighted the similarities in SFCT and CVI between neovascular and atrophic PSD, both of which were late stage lesions. Besides, age, SFCT, patched hyper-reflective lesions in choriocapillaris layers, and DLSs were risk factors for CNV in PSD. Our results showed that atrophic PSD is an important change in the late stage of PSD disease, which is helpful for in-depth understanding of the pathological mechanism of PSD and corresponding intervention.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases

Hua

Zhang

2022

Front. Med.

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“…4 Furthermore, our previous study observed good repeatability in CVI calculation using spectral-domain OCT in the healthy population regardless of age. 5 As a result, we think that CVI is a reproducible measurement method with high reliability.…”

Section: Dear Editormentioning

confidence: 97%

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Koçak

2022

European Journal of Ophthalmology

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“…Objective supplemental information about the choroid's structure, including ChT and the choroidal vascular index (CVI), has also been made available in recent years by virtue of binarization, a method that allows viewing the choroid in greater detail [7]. Such techniques have revealed that ChT and CVI are affected by refractive abnormalities, age, and ethnicity [8][9]. In other recent studies, short-term alterations in ChT and CVI have also been identi ed as being associated with time of day, caffeine consumption, and smoking [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Seasonal Allergic Conjunctivitis and its Treatment on Choroidal Vascular Index

2022

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Effects of age and binarising area on choroidal vascularity index in healthy eyes: an optical coherence tomography study

Cited by 23 publications

References 35 publications

Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases

Imaging Characteristics of Neovascular and Atrophic Pachychoroidal Spectrum Diseases

Reply to letter to editor

The Influence of Seasonal Allergic Conjunctivitis and its Treatment on Choroidal Vascular Index

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