Effects of Age and Serum 25-OH-Vitamin D on Serum Parathyroid Hormone Levels

Valcour, André; Blocki, Frank; Hawkins, Douglas M.; Rao, Sudhaker D

doi:10.1210/jc.2012-2276

Cited by 177 publications

(144 citation statements)

References 37 publications

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“…In agreement with the literature, an inverse logarithmic relationship between 25(OH)D and serum PTH was confirmed [36] [41]. In a survey of more than 900 Australian women [42], PTH concentration was found to be associated with ionized calcium, age, weight and 25(OH)D concentration, with the latter variable being the determinant of greater significance in the multivariate analysis (r = −0.21).…”

Section: Discussionsupporting

confidence: 87%

Hypovitaminosis D and Associated Risk Factors in Postmenopausal Women

Masoni¹,

Menoyo²,

Bocanera³

et al. 2014

Health

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Given the relevance of vitamin D in calcium metabolism homeostatic control, as well as its role as differentiation and cell proliferation modulator, it is important to study its circulating level in patients considered at risk, in order to develop prevention strategies. We studied 77 postmenopausal women with no history of osteoactive drug therapy, corticosteroid intake or diseases that could alter bone metabolism, attending the Menopause Center at the Hospital Provincial del Centenario, Rosario, Argentina. A medical history was taken, and a food consumption frequency questionnaire was applied in order to estimate daily calcium intake. To assess daily physical exercise, work and sports activities were investigated. Serum parathyroid hormone (PTH) and 25(OH)D were measured, and a hip DXA scan was performed in every patient. An inappropriate level of 25(OH)D was observed in 86.3% of patients. The 25(OH)D average value was found within the insufficiency range (<30 ng/ml) whereas PTH average concentration fell within the normal range, and bone mineral density average value was found within the osteopenic category. A statistically significant negative logarithmic association was observed between serum PTH level and vitamin D status (p = 0.01). Mean 25(OH)D concentration among patients who had reported fractures was significantly lower than the corresponding to women who had not suffered this type of event. Patients with vitamin D deficiency had significantly wider mean Cobb angle; higher sum of wedge angles of T4 -T12 vertebral bodies mean values, and higher uncompromised vertebrae wedge angle values than non-deficient women. This study shows high hypovitaminosis D occurrence among these postmenopausal women.

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Section: Discussionsupporting

confidence: 87%

Hypovitaminosis D and Associated Risk Factors in Postmenopausal Women

Masoni¹,

Menoyo²,

Bocanera³

et al. 2014

Health

View full text Add to dashboard Cite

show abstract

“…Whether the observed seasonal variation in vitamin D concentration is pathological and not normal physiology is difficult to assess. The definition of vitamin D sufficiency, often regarded as the concentration above which PTH cannot be suppressed further, varies widely (e.g., from 30 to 110 nmol/L [60]) and indeed, in the largest study to date, no threshold above which increasing vitamin D concentration failed to further suppress PTH could be identified [62]. Furthermore, the relationship between PTH and vitamin D was highly dependent on age [62].…”

Section: We Recommend Edta Plasma Samples For Pth Measurement Should mentioning

confidence: 99%

“…The definition of vitamin D sufficiency, often regarded as the concentration above which PTH cannot be suppressed further, varies widely (e.g., from 30 to 110 nmol/L [60]) and indeed, in the largest study to date, no threshold above which increasing vitamin D concentration failed to further suppress PTH could be identified [62]. Furthermore, the relationship between PTH and vitamin D was highly dependent on age [62]. The population in which PTH is most commonly measured is also known to have a high prevalence of vitamin D deficiency/insufficiency [63] and therefore use of a PTH reference range derived in vitamin D repleted individuals may be inappropriate.…”

Section: We Recommend Edta Plasma Samples For Pth Measurement Should mentioning

confidence: 99%

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

Hanon

Sturgeon

Lamb

2013

Clinical Chemistry and Laboratory Medicine (CCLM)

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Parathyroid hormone (PTH) is relatively unstable: optimisation of pre-analytical conditions, including specimen type, sampling time and storage conditions, is essential. We have undertaken a systematic review of these pre-analytical conditions. An electronic search of the PubMed, Embase, Cochrane, Centre for Research and Dissemination and Bandolier databases was undertaken. Of 5511 papers identified, 96 underwent full text review, of which 83 were finally included. At room temperature PTH was stable in ethylenediaminetetraacetic acid (EDTA) preserved whole blood for at least 24 h and in EDTA plasma for at least 48 h after venepuncture. Losses were observed in clotted blood samples after 3 h and in serum after 2 h. At 4°C PTH was more stable in EDTA plasma (at least 72 h) than serum (at least 24 h). Central venous PTH concentrations were higher than peripheral venous concentrations. In the northern hemisphere, PTH concentrations were higher in winter than summer. PTH has a circadian rhythm characterised by a nocturnal acrophase and mid-morning nadir. Data related to frozen storage of PTH (−20°C and −80°C) were limited and contradictory. We recommend that blood samples for PTH measurement should be taken into tubes containing EDTA, ideally between 10:00 and 16:00, and plasma separated within 24 h of venepuncture. Plasma samples should be stored at 4°C and analysed within 72 h of venepuncture. Particular regard must be paid to the venepuncture site when interpreting PTH concentration. Further research is required to clarify the suitability of freezing samples prior to PTH measurement.

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“…The definition of vitamin D deficiency, insufficiency, and sufficiency is currently challenging as an overall consensus is still lacking (48,49,50 In recent years, a number of position statements and clinical practice guidelines have been published to define the optimal vitamin D status and the health outcomes associated with its alteration (52,53). Many different recommendations on dietary intakes needed to reach and maintain sufficient 25(OH)D levels have been proposed as well (54,55,56,57,58,59).…”

Section: Vitamin D and The Search For A Thresholdmentioning

confidence: 99%

“…Actually, maximal intestinal calcium absorption, serum PTH suppression (52,53), reduced risk of falling, prevention of fractures, increase in BMD, and reduced histomorphometric findings of osteomalacia from bone biopsy are the most important parameters considered in both reports to identify the optimal vitamin D status (58,59,64,65,66). Table 1 briefly summarizes the different conclusions about these skeletal outcomes reached by the two professional organizations.…”

Section: Vitamin D and The Search For A Thresholdmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Value and limitations of assessing vitamin D nutritional status and advised levels of vitamin D supplementation

Romagnoli

Pepe

Piemonte

et al. 2013

European Journal of Endocrinology

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The growing attention to the role of vitamin D in skeletal and extra-skeletal diseases over the last decade induced an increased demand for vitamin D determination as well as a dramatic rise of sales of vitamin D supplement. However, several critical points in this field remain to be clarified. We lack a clear consensus about the definition of vitamin D deficiency, insufficiency, and sufficiency. The identification of different thresholds defining vitamin D status has relevant implications in clinical practice. In fact, the worldwide prevalence of low vitamin D status is highly varying according to the level of 25(OH)D utilized to define sufficiency. Therefore, the assessment of 25-hydroxyvitamin D levels may have a critical role, but a number of different technical problems associated with its determination may interfere in interpreting the results. The hydrophobic nature of vitamin D and the tight binding to its carrier (vitamin D binding protein), the different forms circulating in blood, and the issue of standardization are among the most important factors influencing the measurement of this metabolite. Another controversial point relies on the conflicting guidance on prevention and treatment of vitamin D deficiency endorsed by different medical and scientific communities. In particular, uncertainty exists about how to replete vitamin D stores, how to maintain normal 25(OH)D levels after repletion, which form of vitamin D is preferable for supplementation, and which route of administration and dosing regimens are advisable. Finally, concerns have been raised regarding vitamin D toxicity and its adverse effects.

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Effects of Age and Serum 25-OH-Vitamin D on Serum Parathyroid Hormone Levels

Cited by 177 publications

References 37 publications

Hypovitaminosis D and Associated Risk Factors in Postmenopausal Women

Hypovitaminosis D and Associated Risk Factors in Postmenopausal Women

Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review

MANAGEMENT OF ENDOCRINE DISEASE: Value and limitations of assessing vitamin D nutritional status and advised levels of vitamin D supplementation

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