Effects of age and spectral shaping on perception and neural representation of stop consonant stimuli

Harkrider, Ashley W.; Plyler, Patrick N.; Hedrick, Mark

doi:10.1016/j.clinph.2005.05.016

Cited by 66 publications

(100 citation statements)

References 24 publications

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“…Increased N1 and/or P2 latencies have been associated with a general slowing of neuronal processing, as well as changes in excitatory and inhibitory processes, which can result in decreased neuronal synchrony or temporal jitter within the auditory pathway. With regard to amplitudes, some studies report similar N1-P2 amplitudes for younger and older subjects (Barrett et al, 1987;Brown et al, 1983;Picton et al, 1984;Tremblay et al, 2004), whereas others report an age-related increase in amplitudes (Anderer et al, 1996;Harkrider et al, 2005;Pfefferbaum et al, 1980). Like the N1-P2, age-related increases in amplitude have been reported for other cortical potentials (Boettcher et al, 2001;Woods et al, 1986).…”

Section: Introductionmentioning

confidence: 81%

Electrophysiologic correlates of intensity discrimination in cortical evoked potentials of younger and older adults

2007

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When measured behaviorally, older adults with normal hearing have poorer intensity discrimination thresholds than younger adults, but only at lower frequencies. Poor intensity discrimination at lower but not higher frequencies for older adults can be associated with an age-related decline in temporal processing. The current study was designed to assess age-related effects on intensity discrimination at 500 and 3000 Hz using the cortical auditory evoked potential, N1-P2. Subjects were 10 younger and 10 older adults with normal hearing. The N1-P2 was elicited by an intensity increase in an otherwise continuous pure tone presented at 70 dB SPL. Intensity increments ranged from 0 dB to 5 dB at 500 Hz and from 0 dB to 8 dB at 3000 Hz in 1-dB steps. Intensity discrimination threshold was defined as the smallest intensity change needed to evoke an N1-P2 response. Consistent with behavioral measures, N1-P2 response thresholds were significantly higher for older subjects than younger subjects at 500 Hz but did not differ significantly at 3000 Hz. In addition, N1 and P2 latencies for older subjects were significantly prolonged at 500 Hz, but not at 3000 Hz. As intensity increments increased above threshold, amplitudes tended to be larger in older than in younger subjects, however, these differences were not statistically significant. In older subjects, response latencies and amplitudes were significantly larger at 500 Hz than at 3000 Hz. In younger subjects, response latencies and amplitudes were similar across frequency. Similar intensity discrimination thresholds and age-related differences for behavioral measures and evoked potentials support the notion that the N1-P2 measures reflect the physiological detection of intensity change which in turn relates to intensity discrimination. A possible explanation for the decreased intensity discrimination at low frequencies, and enhanced amplitudes with prolonged latencies in older subjects is an age-related decline in inhibitory control within the central auditory nervous system.

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Section: Introductionmentioning

confidence: 81%

Electrophysiologic correlates of intensity discrimination in cortical evoked potentials of younger and older adults

2007

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“…Moreover, Tremblay et al (2004) reported that N1 latencies were prolonged in older subjects in response to changes in the temporal cues of speech stimuli, but not to the onset of a simple pure-tone stimulus, and hypothesized that age-related changes in N1 may be due to reduced neural synchrony and not simply a result of age-related delays in neural conduction times. Similarly, Harkrider et al (2005) observed that P2 latencies were delayed in older subjects in response to changes in the spectral cues of speech stimuli and suggested that prolonged latencies in older listeners may be due to reduced neural synchrony in response to changes in spectral cues. Bertoli et al (2005) observed similar increases in P2 latencies in older normal-hearing and hearing-impaired adults as compared to younger adults.…”

Section: Effect Of Age On P1 N1 and P2 Response Latencies And Amplimentioning

confidence: 87%

“…In contrast, although P1-N1-P2 thresholds were significantly larger at 500 Hz for older than younger subjects, P1 and N1 amplitudes appeared larger (not smaller) in older than in younger subjects, although differences did not reach statistical significance. Several studies have reported age-related increases in P1 amplitudes (Tremblay et al, 2004) and N1 amplitudes (Harkrider et al, 2005;Harris et al, 2007). Additionally, Boettcher et al (2002) reported increased amplitudes of the FMFR in older than younger subjects using a frequency-modulated sinusoid with a 500-Hz carrier frequency.…”

Section: Effect Of Age On P1 N1 and P2 Response Latencies And Amplimentioning

confidence: 96%

“…In general, P1-N1-P2 responses are larger at frontal midline electrode sites, including Cz. Additionally, several studies examining aging effects have reported results from these midline electrode sites (Anderer et al, 1996;Harkrider et al, 2005;McCandless et al, 1970;Tremblay et al, 2004;Yingling et al, 1983), allowing for comparisons with the current study. However, age-related changes in the scalp topography of the P1-N1-P2 have also been reported (Anderer et al, 1996;Smith et al, 1980).…”

Section: Effect Of Age On P1 N1 and P2 Response Latencies And Amplimentioning

confidence: 99%

“…Pronounced effects of aging have been reported for P1-N1-P2 response latencies and amplitudes (Anderer et al, 1996;Boutros et al, 2000;Harkrider et al, 2005;Laffont et al, 1989;Pfefferbaum et al, 1980;Schroeder et al, 1995;Tremblay et al, 2004;Woods, 1992). However, less is known about age-related effects on response amplitudes and latencies when the P1-N1-P2 response is used to measure acoustic changes contained within a signal.…”

Section: Introductionmentioning

confidence: 99%

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Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials

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The role of the arcuate and middle longitudinal fasciculi in speech perception in noise in adulthood

Tremblay

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In this article, we used High Angular Resolution Diffusion Imaging (HARDI) with advanced anatomically constrained particle filtering tractography to investigate the role of the arcuate fasciculus (AF) and the middle longitudinal fasciculus (MdLF) in speech perception in noise in younger and older adults. Fourteen young and 15 elderly adults completed a syllable discrimination task in the presence of broadband masking noise. Mediation analyses revealed few effects of age on white matter (WM) in these fascicles but broad effects of WM on speech perception, independently of age, especially in terms of sensitivity and criterion (response bias), after controlling for individual differences in hearing sensitivity and head size. Indirect (mediated) effects of age on speech perception through WM microstructure were also found, after controlling for individual differences in hearing sensitivity and head size, with AF microstructure related to sensitivity, response bias and phonological priming, and MdLF microstructure more strongly related to response bias. These findings suggest that pathways of the perisylvian region contribute to speech processing abilities, with relatively distinct contributions for the AF (sensitivity) and MdLF (response bias), indicative of a complex contribution of both phonological and cognitive processes to age‐related speech perception decline. These results provide new and important insights into the roles of these pathways as well as the factors that may contribute to elderly speech perception deficits. They also highlight the need for a greater focus to be placed on studying the role of WM microstructure to understand cognitive aging.

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Effects of age and spectral shaping on perception and neural representation of stop consonant stimuli

Cited by 66 publications

References 24 publications

Electrophysiologic correlates of intensity discrimination in cortical evoked potentials of younger and older adults

Electrophysiologic correlates of intensity discrimination in cortical evoked potentials of younger and older adults

Age-related differences in sensitivity to small changes in frequency assessed with cortical evoked potentials

The role of the arcuate and middle longitudinal fasciculi in speech perception in noise in adulthood

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