Effects of age, breast density, ethnicity, and estrogen replacement therapy on screening mammographic sensitivity and cancer stage at diagnosis: review of 183,134 screening mammograms in Albuquerque, New Mexico.

Rosenberg, Robert D.; Hunt, William C.; Williamson, Michael; Gilliland, Frank D.; Wiest, Philip W.; Kelsey, Charles A.; Key, Charles R.; Linver, Michael N.

doi:10.1148/radiology.209.2.9807581

Cited by 341 publications

(200 citation statements)

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“…Although it is not a standard recommendation, many breast radiologists advocate the adjunct use of ultrasonography for such populations. [15][16][17] All six patients with interval disease had aggressive pathologic characteristics (Table 3), which are consistent with the findings of larger reviews involving BRCA mutation carriers. 18 -20 Again, these findings suggest that a shorter interval between breast …”

Section: Discussionsupporting

confidence: 84%

The development of interval breast malignancies in patients with BRCA mutations

Komenaka

Ditkoff²,

Joseph³

et al. 2004

Cancer

148

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BACKGROUNDAt present, there is no consensus regarding how frequently BRCA mutation carriers should be screened for malignancies using breast imaging techniques. An interval malignancy is defined as a malignancy that becomes evident during the period between annual screening mammography scans; the finding of such a malignancy indicates that the malignancy either went undetected by the last breast imaging scan or developed during the interval since that last scan.METHODSThe authors retrospectively reviewed the medical charts of all BRCA mutation carriers who were followed by the genetic counselor at the Columbia‐Presbyterian Comprehensive Breast Center (New York, NY) between September 1995 and September 2002.RESULTSThirteen BRCA mutation carriers elected to undergo close surveillance and thus were followed at our institution. Three of these 13 patients (23%) did not develop breast carcinoma, 4 (31%) developed breast carcinoma that was detected at the time of annual screening, and 6 (46%) developed palpable interval malignancies in less than 12 months. Among the six patients who developed interval malignancies, the mean time between the last screening mammogram and disease presentation was 5.1 months (range, 2–9 months); the average tumor size in this patient subgroup was 1.7 cm (range, 0.8–3 cm). Two of these six patients had ductal carcinoma in situ, whereas the remaining four had invasive breast carcinoma; three patients had positive lymph nodes at presentation. All six patients who developed interval disease exhibited dense breast tissue on the previous mammogram. Focused breast ultrasonography was able to identify the tumor mass in 3 of 4 patients (75%).CONCLUSIONSNearly half of all BRCA‐positive women who chose to undergo close surveillance in the current study developed malignant disease less than a year after exhibiting normal findings on screening mammography. Half of these interval malignancies were positive for lymph node involvement. These results suggest that strong consideration should be given to screening BRCA‐positive women at more frequent intervals and to using additional imaging techniques, such as breast ultrasonography and/or breast magnetic resonance imaging, as a part of this screening. Cancer 2004. © 2004 American Cancer Society.

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Section: Discussionsupporting

confidence: 84%

The development of interval breast malignancies in patients with BRCA mutations

Komenaka

Ditkoff²,

Joseph³

et al. 2004

Cancer

148

View full text Add to dashboard Cite

show abstract

“…Conventional mammography and (despite some progress) full-field digital mammography (MX) have limitations, particularly in dense [4] and treated breasts. Ultrasound is a complementary technique to mammography, especially for dense breasts [5] and is part of the standard of care in diagnostic procedures.…”

Section: Introductionmentioning

confidence: 99%

Dual-energy contrast-enhanced digital mammography: initial clinical results

Dromain

Thibault

Muller³

et al. 2010

Eur Radiol

242

158

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Objective To assess the diagnostic accuracy of Dual-Energy Contrast-Enhanced Digital Mammography (CEDM) as an adjunct to mammography (MX) versus MX alone and versus mammography plus ultrasound (US). Materials and methods 120 women with 142 suspect findings on MX and/or US underwent CEDM. A pair of low-and high-energy images was acquired using a modified full-field digital mammography system. Exposures were taken in MLO at 2 min and in CC at 4 min after the injection of 1.5 ml/kg of an iodinated contrast agent. One reader evaluated MX, US and CEDM images during 2 sessions 1 month apart. Sensitivity, specificity, and area under the ROC curve were estimated. Results The results from pathology and follow-up identified 62 benign and 80 malignant lesions. Areas under the ROC curves were significantly superior for MX+CEDM than it was for MX alone and for MX+US using BI-RADS. Sensitivity was higher for MX+CEDM than it was for MX (93% vs. 78%; p<0.001) with no loss in specificity. The lesion size was closer to the histological size for CEDM. All 23 multifocal lesions were correctly detected by MX+CEDM vs. 16 and 15 lesions by MX and US respectively. Conclusion Initial clinical results show that CEDM has better diagnostic accuracy than mammography alone and mammography+ultrasound.

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“…The sensitivity ranges between 63-87% depending on the degree of breast density and age (4)(5)(6). Thus, especially in dense breast tissue, further imaging methods are applied to improve the diagnostic accuracy.…”

mentioning

confidence: 99%

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

T¹,

G²,

Sezgin³

et al. 2016

Balkan Med J

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Background: Magnetic resonance imaging (MRI) has become a diagnostic and problem solving method for the breast examinations in addition to conventional breast examination methods. Diffusion-weighted imaging (DWI) adds valuable information to conventional MRI. Aims: Our aim was to show the impact of apparent diffusion coefficient (ADC) values acquired with DWI to differentiate benign and malignant breast lesions. Study Design: Diagnostic accuracy study. Methods: Forty-six women with 58 breast masses (35 malignant, 23 benign) were examined on a 1.5 T clinical MRI scanner. The morphologic characteristics of the lesions on conventional MRI sequences and contrast uptake pattern were assessed. ADC values of both lesions and normal breast parenchyma were measured. The ADC values obtained were statistically compared with the histopathologic results using Paired Samples t-Test. Results: Multiple lesions were detected in 12 (26%) of the patients, while only one lesion was detected in 34 (74%). Overall, 35 lesions out of 58 were histopathologically proven to be malignant. In the dynamic contrast-enhanced series, 5 of the malignant lesions were type 1, while 8 benign lesions revealed either type 2 or 3 time signal intensity curves (85% sensitivity, 56% spesifity Breast cancer is the most common cancer in females worldwide and the second main cause of cancer death following lung cancer. Approximately 12% of women will experience breast cancer during their lifetime (1). Therefore, breast cancer maintains its importance as a serious public health issue. The major risk factors comprise family history, genetic predisposition caused by the presence of a BRCA1 or BRCA2 gene mutation, and previously acquired breast lesions including fibrovascular papilloma, atypical ductal and lobular hyperplasia, and ductal and lobular carcinoma in situ (2,3).Imaging is crucial to diagnose and evaluate the stage and extent of breast cancer. Therefore, three types of radiologic techniques, including mammography, ultrasonography (US) and breast magnetic resonance imaging (MRI), are implemented. As a basic breast cancer scanning method, mammography is highly available, with a short scanning time.

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Effects of age, breast density, ethnicity, and estrogen replacement therapy on screening mammographic sensitivity and cancer stage at diagnosis: review of 183,134 screening mammograms in Albuquerque, New Mexico.

Cited by 341 publications

References 0 publications

The development of interval breast malignancies in patients with BRCA mutations

The development of interval breast malignancies in patients with BRCA mutations

Dual-energy contrast-enhanced digital mammography: initial clinical results

Value of Apparent Diffusion Coefficient Values in Differentiating Malignant and Benign Breast Lesions

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