Effects of aging on coronary flow reserve in patients with no evidence of myocardial perfusion abnormality

Erasta, Ramandika; Kurisu, Satoshi; Nitta, Kazuhiro; Hidaka, Takayuki; Utsunomiya, Hiroto; Ishibashi, Ken; Ikenaga, Hiroki; Fukuda, Yukihiro; Kihara, Yasuki; Nakano, Yukiko

doi:10.1007/s00380-020-01643-8

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…21,22 Aging is further associated with decreased coronary blood velocity and impaired coronary flow reserve. 23,24 However, the upslope cor of young adults with TS decreased more significantly compared with that of normal controls in this work. In addition, the myocardial signal intensity took too long to reach the maximum in the young adult group, suggesting that myocardial microvascular dysfunction was aggravated with age in the early stages of TS and clinicians should be alert to reduced myocardial microcirculation in them.…”

Section: Discussioncontrasting

confidence: 59%

“…With aging, the vasodilatory function of coronary resistance arteries and arterioles is impaired 21,22 . Aging is further associated with decreased coronary blood velocity and impaired coronary flow reserve 23,24 . However, the upslope cor of young adults with TS decreased more significantly compared with that of normal controls in this work.…”

Section: Discussionmentioning

confidence: 50%

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Evaluation of coronary microvascular dysfunction and risk factors in children and youth with Turner syndrome by magnetic resonance myocardial perfusion imaging

Bai

Huang

et al. 2022

Clinical Endocrinology

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Objective Turner syndrome (TS) has an increased predisposition to ischaemic heart disease and the status of coronary microcirculation in TS is largely unknown. This study aims to evaluate myocardial microvascular function in TS using first‐pass magnetic resonance perfusion imaging and determine significant risk factors contributing to microvascular dysfunction in the early stage. Design Perspective cohort study. Patients The study cohort consisted of 67 children and youth with TS and 32 age‐ and gender‐matched controls. Measurements Clinical characteristics, left ventricle (LV) volume and function and cardiovascular magnetic resonance‐derived myocardial perfusion parameters were assessed. Univariable and multivariable linear regression analyses were performed to assess the potential risk factors for microvascular dysfunction. Result Microvascular perfusion decreased in TS in global and segmented myocardium as reflected in the lower upslopecor and maximum signal intensity (MaxSI) of LV myocardium compared to controls. Multivariable linear regression analysis indicated that age (β = −0.107, 95% confidence interval [CI] = −0.201 to −0.013, p = .026) and being overweight/obese (β = −1.155, CI = −2.134 to −0.176, p = .021) were independent impact factors of microvascular dysfunction. Subgroup analysis showed the upslopecor of older patients with TS decreased more significantly compared with that of normal controls. Upslopecor and MaxSI were lower in overweight/obese patients with TS than in patients with normal body mass index (BMI) and controls. Conclusion Myocardial microvascular dysfunction can occur in children and youth patients with TS. Age and overweight/obesity were the independent risk factors of microvascular dysfunction, which imply the importance of lowering BMI for the prevention of coronary heart disease in young TS population.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 50%

Evaluation of coronary microvascular dysfunction and risk factors in children and youth with Turner syndrome by magnetic resonance myocardial perfusion imaging

Bai

Huang

et al. 2022

Clinical Endocrinology

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“…Older people develop cardiac dysfunction, characterized by impaired left ventricular relaxation and contractility, coronary artery thickening and stiffness, and dysfunctional endothelium resulting in reduced coronary flow reserve. [1][2][3][4][5] Structural and functional alterations are documented in cardiomyocytes, endothelial cells, and fibroblasts, 6 and associated with microvascular rarefaction. 7 Moreover, recent experimental evidence indicates pericyte (PC) coverage is reduced, and the cross-talk with neighbor cells is weakened in the heart and other organs of old mice.…”

Section: Introductionmentioning

confidence: 99%

The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy

Cattaneo

Beltrami

Thomas

et al. 2023

Cardiovascular Research

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Aims The aging heart naturally incurs a progressive decline in function and perfusion that available treatments cannot halt. However, some exceptional individuals maintain good health until the very late stage of their life due to favourable gene-environment interaction. We have previously shown that carriers of a longevity-associated variant (LAV) of the BPIFB4 gene enjoy prolonged health spans and lesser cardiovascular complications. Moreover, supplementation of LAV-BPIFB4 via an adeno-associated viral vector improves cardiovascular performance in limb ischemia, atherosclerosis, and diabetes models. Here, we asked if the LAV-BPIFB4 gene could address the unmet therapeutic need to delay the heart’s spontaneous aging. Methods and Results Immunohistological studies showed a remarkable reduction in vessel coverage by pericytes in failing hearts explanted from elderly patients. This defect was attenuated in patients carrying the homozygous LAV-BPIFB4 genotype. Moreover, pericytes isolated from older hearts showed low levels of BPIFB4, depressed pro-angiogenic activity, and loss of ribosome biogenesis. LAV-BPIFB4 supplementation restored pericyte function and pericyte-endothelial cell interactions through a mechanism involving the nucleolar protein nucleolin. Conversely, BPIFB4 silencing in normal pericytes mimed the heart failure pericytes. Finally, gene therapy with LAV-BPIFB4 prevented cardiac deterioration in middle-aged mice and rescued cardiac function and myocardial perfusion in older mice by improving microvasculature density and pericyte coverage. Conclusions We report the success of the LAV-BPIFB4 gene/protein in improving homeostatic processes in the heart’s aging. These findings open to using LAV-BPIFB4 to reverse the decline of heart performance in older people.

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“…In addition, as described in previous reports [26] age-related comorbidity and a higher bleeding risk could conditioned a lower use of new antiplatelet agents in the elderly group. This fact along with that age by itself can lead to an impaired coronary microcirculation state [27] , could explain this higher rate of TIMI flow grade < 3 after PCI, and in turn, could also influence the outcomes.…”

Section: Discussionmentioning

confidence: 99%

“Impact of age on management and prognosis of resuscitated sudden cardiac death patients”

Roselló

Vidal-Burdeus

Loma-Osorio

et al. 2022

IJC Heart & Vasculature

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Effects of aging on coronary flow reserve in patients with no evidence of myocardial perfusion abnormality

Abstract: Effects of aging on coronary flow reserve in patients withno evidence of myocardial perfusion abnormality.

Cited by 7 publications

References 28 publications

Evaluation of coronary microvascular dysfunction and risk factors in children and youth with Turner syndrome by magnetic resonance myocardial perfusion imaging

Evaluation of coronary microvascular dysfunction and risk factors in children and youth with Turner syndrome by magnetic resonance myocardial perfusion imaging

The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy

“Impact of age on management and prognosis of resuscitated sudden cardiac death patients”

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