Effects of aging on hematopoietic stem and progenitor cells

Cell cycle regulation in hematopoietic stem cells

“…Furthermore, it should be emphasized that these pathways may also act as critical regulators of HSC cell cycle mice (Rossi et al, 2005). However, whether this is a result of a true change in self-renewal versus a clonal change in the composition of the HSC compartment is currently debated (Cho et al, 2008;Waterstrat and Van Zant 2009;Beerman et al, 2010a).…”

Regeneration, Stem Cells, and Aging in the Tunicate Ciona

“…Conboy and Rando, 2005;Sharpless and Schatten, 2009;Waterstrat and Van Zant, 2009). It is remarkable that all stages in the life and function of adult stem cells, from their initial formation during metamorphosis (or perhaps even during embryogenesis) to their possible depletion or decay during old age, are accessible for study in Ciona.…”

Effect of aged bone marrow microenvironment on mesenchymal stem cell migration

“…Many studies have focused on the effect of the microenvironment on HSC aging and indicated that HSCs from older mice have a significantly lower cycling activity and a reduced lymphoid differentiation potential than those isolated from young mice (de Haan et al 1997;Li et al 2001;Donnini et al 2007;Zhu et al 2007). Additionally, in the BM microenvironment, aged BM progenitors produce greater numbers of myeloid than lymphoid lineage cells as compared to young BM progenitors (Morrison et al 1996;Sudo et al 2000;Waterstrat and Van Zant 2009;Zediak et al 2007). Min et al found that the number of common lymphoid progenitors (CLPs), pro-B cells, and pre-B cells in BM from aged mice was significantly less than that in BM from young mice (Min et al 2006).…”