Effects of aging on slowing of motor-response generation

Falkenstein, Michael; Yordanova, Juliana; Kolev, Vasil

doi:10.1016/j.ijpsycho.2005.08.004

Cited by 125 publications

(116 citation statements)

References 39 publications

(38 reference statements)

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“…Despite socioeconomic homogeneity of our current study participants, we found that educational attainment was related to timed- Consequently, timed-based measurements may detect the common factor of age-related slowing in motor response [35].…”

Section: Discussioncontrasting

confidence: 55%

Predicting hand function in older adults: evaluations of grip strength, arm curl strength, and manual dexterity

et al. 2016

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Section: Discussioncontrasting

confidence: 55%

Predicting hand function in older adults: evaluations of grip strength, arm curl strength, and manual dexterity

et al. 2016

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“…Recent EEG studies have already indicated that information processing related to anticipation and preparation of a motor response changes during healthy aging (Golob et al 2005;Sterr and Dean 2008). Even though evidence suggests that older adults need stronger (amplitude enhancement) and longer (prolongation of the motor-related potential) activation of the contralateral motor cortex to trigger motor responses (Falkenstein et al 2006;Yordanova et al 2004), it still remains unclear whether these observations reflect deficits in movement preparation or response-generation processes or both. The present study aimed to bridge this gap.…”

Section: Discussionmentioning

confidence: 99%

“…Recent EEG studies have shown that brain activity related to anticipation, preparation, and/or generation of motor responses is changed in healthy aging (Falkenstein et al 2006;Golob et al 2005;Roggeveen et al 2007;Sailer et al 2000;Sterr and Dean 2008;Yordanova et al 2004). More specifically, Sterr and Dean (2008) showed that increased negativity of contingent negative variations (CNVs) in younger individuals during the preparatory period of a precued choice reaction time (CRT) task was associated with higher recruitment of the frontal brain network and lateralized activation over motor regions, whereas these trends were not seen in older individuals.…”

mentioning

confidence: 99%

“…More specifically, Sterr and Dean (2008) showed that increased negativity of contingent negative variations (CNVs) in younger individuals during the preparatory period of a precued choice reaction time (CRT) task was associated with higher recruitment of the frontal brain network and lateralized activation over motor regions, whereas these trends were not seen in older individuals. Observations from studies using lateralized readiness potentials (LRPs) and/or event-related potentials (ERPs) have suggested that behavioral slowing is mainly due to slower response generation, rather than response selection and stimulus processing (Falkenstein et al 2006;Roggeveen et al 2007;Yordanova et al 2004). Specifically, behavioral slowing in elderly individuals may be due to an enhanced and prolonged activity in the contralateral motor cortex during response generation (Falkenstein et al 2006;Yordanova et al 2004).…”

mentioning

confidence: 99%

“…Observations from studies using lateralized readiness potentials (LRPs) and/or event-related potentials (ERPs) have suggested that behavioral slowing is mainly due to slower response generation, rather than response selection and stimulus processing (Falkenstein et al 2006;Roggeveen et al 2007;Yordanova et al 2004). Specifically, behavioral slowing in elderly individuals may be due to an enhanced and prolonged activity in the contralateral motor cortex during response generation (Falkenstein et al 2006;Yordanova et al 2004).…”

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confidence: 99%

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Age-related differences in corticospinal excitability during a choice reaction time task

Cuypers

Thijs

Duqué

et al. 2012

AGE

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Age-related declines in central processing may affect corticospinal (CS) excitability that underlies the emergence of voluntary responses to external stimuli. We used single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex to explore the evolution of CS excitability in 14 young and ten elderly healthy right-handed participants. Motor-evoked potentials (MEPs) were elicited in the right or left first dorsal interosseus (FDI) during the preparatory and premotor periods of a choice reaction time (CRT) task, which required selection of left or right index finger responses. Both age groups showed significant suppression of CS excitability in the preparatory period. However, suppression was generally less pronounced in older than in young adults. Moreover, our data indicated that a reduced suppression in the right FDI during the preparatory period was associated with longer reaction times (RTs) in older adults only. In the premotor period, both age groups demonstrated comparable facilitation levels towards movement onset. Our findings indicate that increased RTs among older individuals could be directly associated with declines in preparatory processes.

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Exploring the impact of chronic high‐altitude exposure on visual spatial attention using the ERP approach

Zhang

Huang

et al. 2018

Brain and Behavior

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IntroductionPrevious studies have reported the slowing of reaction times to attentionally demanding tasks due to a reduction in cognitive resource as a result of chronic high‐altitude exposure. However, it is still largely unknown whether this reaction slowness can be attributed to the attentional allocation change and/or response patterns.MethodsTo clarify this issue, this study investigated attention‐related (N2pc and N2 cc) and response‐related (MP and RAP) event‐related potentials (ERPs) to identify the performance of a visual search task by individuals who had lived in high‐altitude areas for three years compared with those living at sea level.ResultsThis study showed that the reaction times in response to a visual search task were significantly longer in the high‐altitude subjects than in the sea level subjects. Corresponding to this behavioral observation, we found a significantly lower N2pc amplitude and a larger N2 cc amplitude in the high‐altitude subjects, suggesting a reduction in spatial attention allocation to the target (N2pc) in these subjects, indicating they need to work harder to preclude cross‐talk between response selection and attention direction (N2 cc). Moreover, we also discovered higher MP amplitudes and longer RAP latencies in the high‐altitude subjects, which further indicated that these subjects were slower and required greater cortical activation while preparing and executing correctly selected responses (MP and RAP).ConclusionNevertheless, this study collectively provided new insights into the attention reaction slowness from high‐altitude exposure.

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Effects of aging on slowing of motor-response generation

Cited by 125 publications

References 39 publications

Predicting hand function in older adults: evaluations of grip strength, arm curl strength, and manual dexterity

Predicting hand function in older adults: evaluations of grip strength, arm curl strength, and manual dexterity

Age-related differences in corticospinal excitability during a choice reaction time task

Exploring the impact of chronic high‐altitude exposure on visual spatial attention using the ERP approach

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