Effects of aging on the differentiation and proliferation potentials of cells of the immune system

Makinodan, Takashi; Adler, William H.

doi:10.1007/978-1-4684-2631-1_29

Cited by 23 publications

(29 citation statements)

References 29 publications

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“…The diminution of this titer following treatment of the serum with ME further supports the conclusion that the titer in saline can be attributed to an IgM antibody. The titer of this antibody was generally low in the tested sera, ranging from 2 to 64, in agreement with results reported for sera of aged people by Thomsen and Kettel [10] and Somers and Kuhns [9], The low level of IgM antibody in the aged, which decreases progressively from a peak in late adolescence, has been considered to be related to a gradual loss of immunological responsivity with age [4], In contrast to the low titer of IgM antibody, however, we have found that a rather high proportion of the tested sera contained IgG antibody to the A and B determinants. Furthermore, the incidence of the IgG antibody appeared to vary inversely with the titer of the IgM antibody, having been significantly more frequent among sera with a low (2-4) IgM antibody titer (63%) than among those with a higher (16-64) titer (17%).…”

Section: Discussionsupporting

confidence: 77%

High Frequency of IgG Anti-A and -B Antibody in Old Age

Baumgarten¹,

Kruchok²,

Weirich³

1976

Vox Sanguinis

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The titer of anti-A and -B IgM antibody was tested in 57 sera from patients aged 65 years or more. 31 of these sera were also titered for the occurrence and titer of IgG antibody. All sera were found to have a low titer (2-64) of IgM antibody but 14 sera contained IgG antibody. However, only two of 12 sera with a higher IgM antibody titer (16-64) exhibited the IgG antibody in contrast to 12 of 19 sera with a low titer of IgM antibody (2-4). The difference was statistically significant (p = 0.014).

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Section: Discussionsupporting

confidence: 77%

High Frequency of IgG Anti-A and -B Antibody in Old Age

Baumgarten¹,

Kruchok²,

Weirich³

1976

Vox Sanguinis

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“…Thymus-dependent antibody responses, mitogenic responses to phytohemagglutinin and Concanavalin A and responses to allogeneic cells in mixed lymphocyte cultures decline at approximately the same rate with time after puberty (54,55). However, the decline of T cell functions have been primarily detected in the spleen.…”

Section: Lymphoid Systemmentioning

confidence: 99%

“…There appears to be a relative increase in phagocytic accessory cells in spleens of old mice and this could lead to the observed inability to respond to low doses of antigenic stimulation (54,58). Accessory cells do not lose the capacity to interact with T and B cells in antibody responses with age (60).…”

Section: Lymphoid Systemmentioning

confidence: 99%

Effect of Age on Immune Function in Terms of Chemically Induced Cancers

Bennett¹

1979

Environmental Health Perspectives

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Neonatal, fetal, and very old animals are particularly sensitive to chemical carcinogenesis. Reasons for this increased sensitivity could be due to increased susceptibility of "target" organs or cells, peculiar hormonal levels at these age groups, relatively deficient immune functions, or combinations of these and/or other factors. During the late fetal and first three weeks of neonatal life, the immune system is rapidly maturing, is relatively incompetent, and its diverse components are developing at different rates. Gonadotrophic hormones of the pituitary or placenta are high during pregnancy, the early neonatal period, after the menopause, and in a large fraction of men over 60 years of age. These and other hormones are immunosuppressive and could theoretically facilitate carcinogenesis. The particular immune cell type, if any, responsible for resistance to chemically induced tumors has not been determined. One can only state that susceptibility to chemical carcinogenesis is associated with a relative dysfunction of the immune system and that age is an important factor.

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“…The immunological changes which are linked to the process of aging have been the subject of recent re search [1][2][3][4][5]: reports on abnormalities of cell- [6][7][8][9][10] and antibody-mediated immune responses [11][12][13][14][15][16] in both humans and mice, although often contradictory, suggest a decline in T cell function as a major hall mark of the immunopathology of aging. Very little is known about the status of the different cell-mediated effector mechanisms (CMI) in the aged and its possi ble influence in adaptation and survival in the last de cades of life.…”

Section: Introductionmentioning

confidence: 99%

Cell-Mediated Effector Mechanisms in Aging Humans

Marcano¹,

Rivas²,

Figarella³

et al. 1982

Int Arch Allergy Immunol

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Specific and nonspecific cell-mediated effector mechanisms have been simultaneously assayed in 15 aged humans. 8 were female and 7 male, including a 114-year-old male in remarkably good health. Proliferative response to alloantigens, the generation of T killer cells and the ability to express cell-mediated lympholysis as well as the presence of natural cell-mediated cytotoxicity against K562 tumor cell line and the capacity to mount an ADCC response to RhD+ human red blood cell sensitized with anti-D antisera, revealed that in the human aged, while T function significantly declines, nonspecific cell-mediated effector mechanisms are operative.

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Effects of aging on the differentiation and proliferation potentials of cells of the immune system

Cited by 23 publications

References 29 publications

High Frequency of IgG Anti-A and -B Antibody in Old Age

High Frequency of IgG Anti-A and -B Antibody in Old Age

Effect of Age on Immune Function in Terms of Chemically Induced Cancers

Cell-Mediated Effector Mechanisms in Aging Humans

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