Effects of aging on the human motor cortical plasticity studied by paired associative stimulation

Fathi, Dina; Ueki, Yoshino; Mima, Tatsuya; Koganemaru, Satoko; Nakagawa, Takashi; Tawfik, Amal; Fukuyama, Hidenao

doi:10.1016/j.clinph.2009.07.048

Cited by 143 publications

(140 citation statements)

References 31 publications

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“…Although advancing age is related to decline of motor cortical plasticity and mechanisms involved in encoding new motor memories (Sawaki et al, 2003;Fathi et al, 2010), behavioural studies indicate that older subjects may improve motor sequence performance during the early acquisition phase to a degree comparable to that of young subjects (King et al, 2013;Fogel et al, 2014). However, consolidation appears to be prominently impaired in older adults (Spencer et al, 2007;Brown et al, 2009;Fogel et al, 2014;Roig et al, 2014).…”

mentioning

confidence: 93%

Enhancement of motor consolidation by post-training transcranial direct current stimulation in older people

Rumpf

Wegscheider

Hinselmann

et al. 2017

Neurobiology of Aging

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mentioning

confidence: 93%

Enhancement of motor consolidation by post-training transcranial direct current stimulation in older people

Rumpf

Wegscheider

Hinselmann

et al. 2017

Neurobiology of Aging

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“…Other intrinsic differences in protocols used to induce cortical plasticity in humans, e.g., stimulation mode or pulse frequency (Ziemann, 2004), may additionally contribute to differential findings between studies. We chose the PAS protocol (Stefan et al, 2000) for the present study as a frequently used and sensitive tool to investigate cortical plasticity and its relation to age and cognitive function in healthy subjects and neurological patients (Morgante et al, 2006;Weise et al, 2006;Frantseva et al, 2008;Muller-Dahlhaus et al, 2008;Castel-Lacanal et al, 2009;Fathi et al, 2010;Zeller et al, 2010;List et al, 2011List et al, , 2012.…”

Section: Bdnf Val66met and Brain Stimulationmentioning

confidence: 99%

Interaction of BDNF and COMT Polymorphisms on Paired-Associative Stimulation-Induced Cortical Plasticity

Witte¹,

Kürten²,

Jansen³

et al. 2012

J. Neurosci.

101

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The common single-nucleotide polymorphism (SNP) brain-derived neurotrophic factor (BDNF) valine-to-methionine substitution at codon 66 (Val66Met) has been associated with differences in memory functions and cortical plasticity following brain stimulation. Other studies could not confirm these results, though, and potential interactions of BDNF carrier status with other learning-relevant SNPs are largely unknown. The present study aimed to evaluate the effects of BDNF Val66Met genotype on paired associative stimulation (PAS)-induced motor cortex plasticity, while additionally taking catechol-O-methyltransferase (COMT) Val158Met and kidney and brain (KIBRA) rs17070145 carrier status into account. Therefore, a cohort of 2 ϫ 16 age-and education-matched healthy young females underwent transcranial magnetic stimulation using an excitatory PAS 25 protocol to induce cortical plasticity. Cognitive performance was assessed using implicit grammar-and motor-learning tasks and a detailed neuropsychological test battery. While BDNF carrier status alone did not significantly influence PAS-induced cortical plasticity, we found a significant BDNF ϫ COMT interaction, showing higher plasticity immediately following the PAS 25 protocol for the BDNF Val/Val vs Met genotype in COMT Met homozygotes only (ANOVA, p ϭ 0.027). A similar advantage for this group was noted for implicit grammar learning (ANOVA, p ϭ 0.021). Accounting for KIBRA rs17070145 did not explain significant variance. Our findings for the first time demonstrate an interaction of BDNF by COMT on human cortical plasticity. Moreover, they show that genotype-related differences in neurophysiology translate into behavioral differences. These findings might contribute to a better understanding of the mechanisms of interindividual differences in cognition.

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“…A number of these identified factors contribute to inter-subject response variability, such as age (Fathi et al 2010;Muller-Dahlhaus et al 2008;Tecchio et al 2008;Todd et al 2010), genetics (Cheeran et al 2008), and motor cortical physiology (Hamada et al 2013). However, several factors have been identified that could contribute to both inter-and intra-subject response variability, such as an individual's history of physical activity (Cirillo et al 2009) and levels of the stress hormone cortisol (Clow et al 2014;Sale et al 2008).…”

mentioning

confidence: 99%

Inter- and intra-subject variability of motor cortex plasticity following continuous theta-burst stimulation

et al. 2015

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Effects of aging on the human motor cortical plasticity studied by paired associative stimulation

Cited by 143 publications

References 31 publications

Enhancement of motor consolidation by post-training transcranial direct current stimulation in older people

Enhancement of motor consolidation by post-training transcranial direct current stimulation in older people

Interaction of BDNF and COMT Polymorphisms on Paired-Associative Stimulation-Induced Cortical Plasticity

Inter- and intra-subject variability of motor cortex plasticity following continuous theta-burst stimulation

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