Effects of AIF on Knee Osteoarthritis Patients: Double-blind, Randomized Placebo-controlled Study

Park, Sunghoon; Kim, Seong-Kyu; Shin, Im-Hee; Kim, Hyunggun; Choe, Jung‐Yoon

doi:10.4196/kjpp.2009.13.1.33

Cited by 26 publications

(34 citation statements)

References 16 publications

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“…This study did not show any significant differences in clinical values between the AIF and control groups; this result is in contrast to results of a previous clinical trial performed in human patients in which the same treatment was used (Park et al, 2009). One possible explanation for the discrepancy is the difference in species of study subjects; there are limitations to detecting pain in horses compared to humans.…”

Section: Discussioncontrasting

confidence: 56%

“…A prospective placebo-controlled clinical trial on human patients with idiopathic osteoarthritis showed significant pain alleviation and improvements in stiffness and physical function in a group treated with AIF twice daily for 6 weeks compared to the control group. This study also showed no significant differences in the incidence of adverse events between the group treated with AIF and the control group (Park et al, 2009).…”

Section: Introductionmentioning

confidence: 59%

“…The three herbs used in this study have been widely used as anti-inflammatory and anti-pyretic drugs in human herbal medicine in eastern Asia for over 2000 years, and their therapeutic dosages and safety have been demonstrated (Park et al, 2009). Panax notoginseng stimulates blood flow, has hematopoietic, anti-inflammatory, and analgesic effects, and has been used for the treatment of cardiovascular diseases and contusions (Li and Chu, 1999;Yoshikawa et al, 2001;Chang et al, 2005;Chang et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have revealed that the mixed extract of these three herbs (AIF) synergistically inhibits the inflammatory process and cartilage destruction, and has disease modifying effects in mouse and rat osteoarthritis models (Chang et al, 2005;Chang et al, 2008). A clinical trial demonstrated that AIF has symptom modifying effects without causing any adverse effects in human patients (Park et al, 2009). The present study demonstrated that, in an experimentally induced osteoarthritis model in horses, AIF has a disease modifying effect and no apparent association with adverse events.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the therapeutic effects of a water extract from three herbs, Panax Notoginseng, Rehmanniae Radix and Acanthopanacis cortex (AIF), on osteoarthritis have been investigated (Chang et al, 2005;Chang et al, 2008;Park et al, 2009). Previous studies have shown that AIF has a protective effect on the progression of arthritis in rat and mouse models (Chang et al, 2005;Chang et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Mixed Extract of Panax Notoginseng, Rehmanniae Radix and Acanthopanacis Cortex (AIF) on Experimentally Induced Osteoarthritis

Park¹,

Kim²,

Ahn³

et al. 2010

Biomolecules and Therapeutics

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-The objective of the present study was to evaluate the effect of a mixed extract of three herbs, Panax Notoginseng, Rehmanniae Radix and Acanthopanacis cortex (AIF), for the treatment of horses with experimentally induced osteoarthritis. Twelve healthy male horses were included in this study. Horses were assigned to one of two groups: the AIF group (n=6) or the control group (n=6). Osteoarthritis was induced in all horses by intraarticular injection of sodium monoiodoacetate (0.12 mg/kg). Horses in the AIF group received 3 g of AIF with food daily, and those in the control group received food only. Treatment began on the day of intraarticular injection. Clinical and radiographic evaluations were performed every 2 weeks. At week 12, horses were euthanatized, and postmortem gross pathologic and histologic examinations of the middle carpal joint were performed. There were no significant differences in clinical values between the two groups. Radiographic evaluation revealed that the percentages of narrowness of joint space width in the control group were significantly higher than those in the AIF group (p＜0.02). On gross pathologic examination, the mean total dimensions of articular cartilage erosions and fibrillations in the control group (101.5 ± 41.5 mm 2 ) were significantly wider than those in the AIF group (29.3 ± 39.7 mm 2 ; p＜0.01). On histopathologic evaluation, significantly higher grades of staining intensity and lower empty lacunae (EL) ratios were found in the AIF group (p＜0.03). The present study revealed that AIF had significant disease modifying effects in horses with experimentally induced osteoarthritis.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Mixed Extract of Panax Notoginseng, Rehmanniae Radix and Acanthopanacis Cortex (AIF) on Experimentally Induced Osteoarthritis

Park¹,

Kim²,

Ahn³

et al. 2010

Biomolecules and Therapeutics

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Oral herbal therapies for treating osteoarthritis

Cameron

Chrubasik

2014

Cochrane Database of Systematic Reviews

104

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Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials

et al. 2016

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Herbal drugs have become a popular form of healthcare, raising concerns about their safety. This study aimed to characterize the adverse effects of herbal drugs through a systematic review of results reported in randomized controlled trials (RCTs). Using eight electronic databases including PubMed, the Cochrane library and six Korean medical databases, the frequency of reported toxicity was recorded based on drug composition and indication. Among 4957 potentially relevant articles, 242 papers comprised of 244 studies met our inclusion criteria; these included 111 studies of a single herb and 133 of multiple herbs. These studies accounted for a total 15 441 participants (male = 5590; female = 9851; 7383 for single and 8058 for multiple herb studies). There were 480 cases (3.1%) of adverse events (344 for single, 136 for multiple herb studies; p < 0.01). A total of 259 cases reported blood test abnormalities, including five cases of abnormality in hepatic functional enzymes. The most frequently reported adverse event was digestive symptoms (44.3%), followed by nervous system symptoms (17.3%) and behaviors such as loss of appetite (16.3%). This is the first systematic review of adverse effects of herbal drugs among clinical studies, and the results indicate that herbal drugs are relatively safe. Copyright © 2016 John Wiley & Sons, Ltd.

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Effects of AIF on Knee Osteoarthritis Patients: Double-blind, Randomized Placebo-controlled Study

Cited by 26 publications

References 16 publications

Effect of Mixed Extract of Panax Notoginseng, Rehmanniae Radix and Acanthopanacis Cortex (AIF) on Experimentally Induced Osteoarthritis

Effect of Mixed Extract of Panax Notoginseng, Rehmanniae Radix and Acanthopanacis Cortex (AIF) on Experimentally Induced Osteoarthritis

Oral herbal therapies for treating osteoarthritis

Systematic Review of Adverse Effects from Herbal Drugs Reported in Randomized Controlled Trials

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