Effects of air pollution on the respiratory health of asthmatic children living in Mexico City.

Romieu, Isabelle; Meneses, Fernando; Ruiz, Sonia E.; Sienra, J.J.; Huerta, J.; White, Mary C.; Etzel, Ruth A.

doi:10.1164/ajrccm.154.2.8756798

Cited by 287 publications

(213 citation statements)

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“…Health effects attributed to the presence of fine and coarse particulates have been studied previously in Mexico City (Castillejos et al, 1992(Castillejos et al, , 1995Romieu et al, 1996Romieu et al, , 1997Romieu et al, , 2002aHolguin-Molina et al, 2003;Loomis and Kromhout, 2004); however, these studies did not take into account personal exposure assessment.…”

Section: Introductionmentioning

confidence: 99%

Relationship between indoor, outdoor, and personal fine particle concentrations for individuals with COPD and predictors of indoor-outdoor ratio in Mexico city

Cortez‐Lugo

Moreno-Macías

Holguin-Molina

et al. 2007

J Expo Sci Environ Epidemiol

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Section: Introductionmentioning

confidence: 99%

Relationship between indoor, outdoor, and personal fine particle concentrations for individuals with COPD and predictors of indoor-outdoor ratio in Mexico city

Cortez‐Lugo

Moreno-Macías

Holguin-Molina

et al. 2007

J Expo Sci Environ Epidemiol

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“…18 Another panel study of children in the Netherlands found that only the group with bronchial hyperresponsiveness and relatively high concentrations of serum total IgE appeared susceptible to air pollution. 19 These observations suggest interactive effects between air pollutants and allergic responses.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Distance from Major Roads and Adolescent Health in Japan.

Miyake

Yura

Iki

2002

Journal of Epidemiology

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A relationship between distance from major roads and the prevalence of allergic disorders and general symptoms among junior high school students was assessed, separating the effects of distance of residence and school from the roads. Study subjects were 5,652 students aged 12 to 15 years. This study used diagnostic criteria from the International Study of Asthma and Allergies in Childhood. The questionnaire also asked about symptoms of headache, stomachache, tiredness, and cough and the shortest distance from residence to major roads. Distance from school to the nearest major road was measured on a map. Adjustment was made for gender, grade, the number of older siblings, smoking in the household, and maternal history of allergy. A shorter distance between residence and major roads was associated with an increased prevalence of headache, stomachache, tiredness, and cough. There was a marginally significant positive association between residence facing major roads and the prevalence of allergic rhinoconjunctivitis. Residence within 100 m of major roads showed a tendency for a positive relationship with the prevalence of wheeze and atopic dermatitis. There was no apparent relationship between distance of school from major roads and allergic disorders or the general symptoms. The findings suggest that proximity of residence, not school, to major roads may be associated with an increased prevalence of allergic disorders, headache, stomachache, and tiredness among Japanese adolescents. Further investigations with more precise and detailed exposure and health outcome measurements are needed to corroborate the relationship between traffic related factors and allergic disorders and general symptoms. Another study in Germany reported an association between the maximum traffic counts in the school districts and childhood respiratory symptoms. A small increase in odds ratio was observed for respiratory infections and the prevalence of wheezing in this study, while there were no differences in the prevalence of asthma and hay fever. 7 A British case-control study showed a significant positive association between road traffic and risk of hospital admission for asthma in children younger than 5 years of age.8However the association was not found in a case-control study of UK children aged 5-14 years. 9 A study in East and West Germany found a significant positive association between residence closer than 50 m from a busy road and the prevalence of atopic eczema. 10In Japan, the prevalence of general symptoms such as headache and tiredness has been increasing among schoolchildren.11 It is hypothesized that changes in the living environment and disordered diet and life style may be responsible for the increase of these symptoms.12 To our knowledge, no studies have examined the effect of road traffic on such symptoms.Schoolchildren spend much of their time at or near their home and school addresses. We assessed the relationship between the distance from major roads and the prevalence of allergic disorders and general symptoms in ...

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“…It is not possible to evaluate whether interactions with allergens also played a role in these effects as relevant data were not reported. There is some evidence that exposure to the smaller fraction of particulate matter (PM2.5), may be more important than that to PM10 for acute respiratory symptoms [23] and even for death from respiratory diseases [24]. Unvented domestic gas appliances may contribute to NO 2 exposure [25].…”

Section: Discussionmentioning

confidence: 99%

Short-term exposure to air pollution in a road tunnel enhances the asthmatic response to allergen

Svartengren¹,

Strand²,

Bylin³

et al. 2000

Eur Respir J

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The aim of this study was to assess whether air pollution in road tunnels would promote asthmatic reactions in persons with mild allergic asthma.Twenty volunteers with mild allergic asthma were exposed, inside a car, for 30 min in a Stockholm city road tunnel. As a control, the subjects were exposed to much lower pollution levels in a suburban area. Four hours after the exposure, the subjects inhaled a low dose of allergen. Asthmatic reaction during the early phase was measured as the increase in specific airway resistance 15 min after allergen inhalation and during the late phase as the decrease in lung function forced expiratory volume in one second 3±10 h after allergen inhalation. Asthma symptoms and drug use were monitored up to 18 h after allergen inhalation.The median nitrogen dioxide level during exposure was 313 mg . m -3 (range 203± 462). The median levels of particles with 50% cut-off aerodynamic diameters of 10 (PM10) and 2.5 mm (PM2.5) were 170 (range 103±613) and 95 (range 61±218) mg . m -3 , respectively. Subjective symptoms during tunnel exposure were not pronounced. However, subjects exposed to tunnel NO 2 levels of $300 mg . m -3 had a significantly greater early reaction, following allergen exposure, as well as lower lung function and more asthma symptoms during the late phase, compared to control. Also, subjects with PM2.5 exposure $100 mg . m -3 had a slightly increased early reaction compared to control.In conclusion, exposure to air pollution in road tunnels may significantly enhance asthmatic reactions to subsequently inhaled allergens. Eur Respir J 2000; 15: 716±724.

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Effects of air pollution on the respiratory health of asthmatic children living in Mexico City.

Cited by 287 publications

References 0 publications

Relationship between indoor, outdoor, and personal fine particle concentrations for individuals with COPD and predictors of indoor-outdoor ratio in Mexico city

Relationship between indoor, outdoor, and personal fine particle concentrations for individuals with COPD and predictors of indoor-outdoor ratio in Mexico city

Relationship between Distance from Major Roads and Adolescent Health in Japan.

Short-term exposure to air pollution in a road tunnel enhances the asthmatic response to allergen

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