Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders

Costa, Lucio G.; Cole, Toby B.; Dao, Khoi; Chang, Yu‐Chi; Coburn, Jacki; Garrick, Jacqueline M.

doi:10.1016/j.pharmthera.2020.107523

Cited by 297 publications

(141 citation statements)

References 325 publications

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“…Air pollutants may play a role in the etiology of psychiatric disorders including depression, anxiety disorders, suicidal behavior and psychoses due to their toxicity on the central nervous system [24][25][26]. For example, exposure to PM 2.5 has been associated with an increased risk of depressive symptoms in older women without prior history of depression or cognitive impairment [27] and with both depressive and anxiety symptoms in community-dwelling older adults [28].…”

Section: Air Pollution and Mental Healthmentioning

confidence: 99%

Physical activity in an air-polluted environment: behavioral, psychological and neuroimaging protocol for a prospective cohort study (Healthy Aging in Industrial Environment study – Program 4)

et al. 2021

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Background Air pollution has been linked to increased mortality and morbidity. The Program 4 of the Healthy Aging in Industrial Environment study investigates whether the health and wellbeing benefits of physical activity (PA) can be fully realized in individuals living in highly polluted environments. Herein, we introduce the behavioral, psychological and neuroimaging protocol of the study. Methods This is a prospective cohort study of N = 1500 individuals aged 18–65 years comparing: (1) individuals living in the highly polluted, industrial region surrounding the city of Ostrava (n = 750), and (2) controls from the comparison region with relative low pollution levels in Southern Bohemia (n = 750). Quota sampling is used to obtain samples balanced on age, gender, PA status (60% active runners vs. 40% insufficiently active). Participants are screened and complete baseline assessments through online questionnaires and in-person lab-based assessments of physiological, biomechanical, neuroimaging and cognitive function parameters. Prospective 12-month intensive monitoring of air pollution and behavioral parameters (PA, inactivity, and sleep) follows, with a focus on PA-related injuries and psychological factors through fitness trackers, smartphones, and mobile apps. Subsequently, there will be a 5-year follow-up of the study cohort. Discussion The design of the study will allow for (1) the assessment of both short-term variation and long-term change in behavioral parameters, (2) evaluation of the incidence of musculoskeletal injuries and psychological factors impacting behavior and injury recovery, and (3) the impact that air pollution status (and change) has on behavior, psychological resilience, and injury recovery. Furthermore, the integration of MRI techniques and cognitive assessment in combination with data on behavioral, biological and environmental variables will provide an opportunity to examine brain structure and cognitive function in relation to health behavior and air pollution, as well as other factors affecting resilience against and vulnerability to adverse changes in brain structure and cognitive aging. This study will help inform individuals about personal risk factors and decision-makers about the impact of environmental factors on negative health outcomes and potential underlying biological, behavioral and psychological mechanisms. Challenges and opportunities stemming from the timing of the study that coincided with the COVID-19 pandemic are also discussed.

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Section: Air Pollution and Mental Healthmentioning

confidence: 99%

Physical activity in an air-polluted environment: behavioral, psychological and neuroimaging protocol for a prospective cohort study (Healthy Aging in Industrial Environment study – Program 4)

et al. 2021

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“…The PM 10 fraction (particles with aerodynamic diameter less or equal to 10 μm), and especially the PM 2.5 fraction (particles with aerodynamic diameter less or equal to 2.5 μm), are the main cause of such effects. PM can penetrate deeply into human lungs and cause cardiovascular, respiratory and neurodegenerative disorders (Boda et al, 2020;Burnett et al, 2014;Costa et al, 2020;Middleton et al, 2008). Metals are considered one of the most challenging and toxic elements present in PM because they cannot degrade biologically or chemically and they tend to bioaccumulate (Chen et al, 2013;Li et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Assessment of metals in PM10 filters and Araucaria heterophylla needles in two areas of Quito, Ecuador

Mancheno

Žalakevičiūtė

González

et al. 2021

Heliyon

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“…(Liu et al, 2012;Han et al, 2017;Lomonaco et al, 2020). The recognition that poor air quality will affect human health and productivity was a realization and major social concern of the twentieth century (Costa et al, 2020). Most of the air decontamination studies that have been conducted to date are focused on SO x , NO x, and VOCs as the main causes of the greenhouse effect, (Xiong et al, 2019;Liu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Photocatalytic Activity of SnO2-TiO2 and ZnO-TiO2 Tandem Structures Toward Indoor Air Decontamination

Eneşca

2020

Front. Chem.

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ZnO-TiO2 and SnO2-TiO2 tandem structures were developed using the doctor blade technique. It was found that by employing organic hydrophilic and hydrophobic as additives into the precursor it is possible to tailor the film density and morphology with direct consequences on the photocatalytic activity of the tandem structures. The highest photocatalytic efficiency corresponds to ZnO-TiO2 and can reach 74.04% photocatalytic efficiency toward acetaldehyde when a hydrophilic additive is used and 70.93% when a hydrophobic additive is employed. The snO2-TiO2 tandem structure presents lower photocatalytic properties (61.35 % when the hydrophilic additive is used) with a constant rate reaction of 0.07771 min−1.

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Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders

Cited by 297 publications

References 325 publications

Physical activity in an air-polluted environment: behavioral, psychological and neuroimaging protocol for a prospective cohort study (Healthy Aging in Industrial Environment study – Program 4)

Physical activity in an air-polluted environment: behavioral, psychological and neuroimaging protocol for a prospective cohort study (Healthy Aging in Industrial Environment study – Program 4)

Assessment of metals in PM10 filters and Araucaria heterophylla needles in two areas of Quito, Ecuador

Enhancing the Photocatalytic Activity of SnO2-TiO2 and ZnO-TiO2 Tandem Structures Toward Indoor Air Decontamination

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