Effects of albendazole against larval and adult Angiostrongylus cantonensis in rats

Lakwo, Tomson T; Ishih, Akira; Terada, Mamoru; Sano, M.

doi:10.1016/s1383-5769(98)00032-4

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…ABZ kills parasites such as the nematode A. cantonensis by blocking the absorption of glucose by the larvae (Hwang and Chen, 1988 ; Lakwo et al ., 1998 ). Thus far, the drug has shown good results for the treatment of angiostrongyliasis (Hwang and Chen, 1991 ).…”

Section: Discussionmentioning

confidence: 99%

Calycosin attenuatesAngiostrongylus cantonensis-induced parasitic meningitis through modulation of HO-1 and NF-κB activation

Chen

Kuo

et al. 2022

Parasitology

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Angiostrongylus cantonensis causes a form of parasitic meningitis in humans. Albendazole (ABZ) kills nematode larvae in the brain. However, dead larvae can trigger a severe inflammatory response, resulting in brain damage. Accumulating evidence suggests that calycosin represents a potential anti-inflammatory therapeutic candidate. In this study, we investigated the combined effects of ABZ and calycosin in angiostrongyliasis caused by A. cantonensis in BALB/c mice. Inflammatory mediators (such as phospho-nuclear factor-κB, cyclooxygenase-2, matrix metalloproteinase-9, tumour necrosis factor-α and interleukin-1β) are associated with the development of meningitis and immune inflammatory reactions. We found that A. cantonensis significantly induces inflammatory mediator production and increases the blood–brain barrier (BBB) permeability. However, co-administration of both ABZ and calycosin markedly suppressed meningitis and inflammatory mediator production and decreased the BBB permeability compared to treatment with a single drug. Furthermore, calycosin and ABZ plus calycosin treatment facilitated production of the antioxidant haem oxygenase-1 (HO-1). Moreover, co-therapy with ABZ and calycosin failed to mitigate angiostrongyliasis in the presence of tin-protoporphyrin IX, an HO-1-specific inhibitor. This finding suggests that the beneficial effects of ABZ plus calycosin treatment on the regulation of inflammation are mediated by the modulation of HO-1 activation. The present results provide new insights into the treatment of human angiostrongyliasis using co-therapy with ABZ and calycosin.

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Section: Discussionmentioning

confidence: 99%

Calycosin attenuatesAngiostrongylus cantonensis-induced parasitic meningitis through modulation of HO-1 and NF-κB activation

Chen

Kuo

et al. 2022

Parasitology

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“…The in vivo efficacy of albendazole based on larva/worm recovery has been studied in various animal models such as mice (Hwang and Chen, 1988;Lan et al, 2004;Tu and Lai, 2006), and rats (Lakwo et al, 1998). These studies have found albendazole to be efficacious against A. cantonensis by reducing worm burden and histological signs of inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, clinical reports have indicated that the use of anthelmintics is associated with negative outcomes (Bowden, 1981;Hidelaratchi et al, 2010), and in one case, the use of an anthelmintic was proven to be ineffective (Kliks et al, 1982). In contrast, several studies and clinical reports on neuroangiostrongyliasis have shown the use of an anthelmintic to be associated with positive outcomes (Cuckler et al, 1964;Bisseru et al, 1972;Lakwo et al, 1998;Jitpimolmard et al, 2007;Li et al, 2008;Wang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

In vitro efficacy of anthelmintics on Angiostrongylus cantonensis L3 larvae

et al. 2020

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Angiostrongylus cantonensis is the leading cause of eosinophilic meningitis worldwide, with life-threatening complications if not managed correctly. Previous in vitro studies have utilized change in motility patterns of adult female worms to assess the efficacy of anthelmintics qualitatively. However, it is the third stage larvae (L3) that are infectious to humans. With differential staining using propidium iodide penetration as the indicator of death, we can distinguish between dead and live larvae. This assay has enabled us to quantify the in vitro efficacy of nine clinically established anthelmintics on A. cantonensis L3. All drugs were tested at a 1 mm concentration. Piperazine and niclosamide were ineffective in inducing larval death; however, albendazole sulfoxide, pyrantel pamoate, diethylcarbamazine, levamisole and praziquantel were effective as compared to unexposed controls (P < 0.05). Ivermectin and moxidectin did not induce significant levels of mortality, but they considerably reduced larval motility almost immediately. This study indicates the need for further in vivo studies to determine the optimal dose and time frame for post-infection treatment with anthelmintics that demonstrated efficacy.

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“…Our results echo those of Hwang and Chen (1988), who documented a total eradication of worms 14 days following the administration of the same dose of albendazole in mice inoculated with 50 larvae. In contrast, in rats inoculated with fewer larvae (15), albendazole was more effective at 7 days than at 14 days (Lakwo et al 1998). The possible reasons for the variation between these two observations are the variation in the host species and the number of inoculated larva.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis

et al. 2004

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Matrix metalloproteinase 9 (MMP-9) is involved in the pathogenesis of parasitic meningitis caused by the nematode Angiostrongylus cantonensis. The present study evaluated the efficacy of albendazole therapy in BALB/c mice infected with the third stage larvae of this nematode. Albendazole showed a pronounced larvicidal activity. Eosinophil numbers significantly increased in infected mice but decreased upon administration of albendazole. Densitometric scanning indicated that albendazole reduced gelatinolytic activity detected by gelatin-substrate zymography. In the cerebrospinal fluid, albendazole reduced the lytic area intensity of the 94 kDa MMP-9 band by 46.5% within 7 days, and by 51.5% by day 14. Examination of brain tissue revealed a similar pattern of decrease (48.6% by day 7, and 53.9% by day 14). Albendazole may thus be an effective compound for the treatment of angiostrongyliasis through its larvicidal activity and facilitation of an improved inflammatory response via the reduction of MMP-9 activity.

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Effects of albendazole against larval and adult Angiostrongylus cantonensis in rats

Cited by 7 publications

References 19 publications

Calycosin attenuatesAngiostrongylus cantonensis-induced parasitic meningitis through modulation of HO-1 and NF-κB activation

Calycosin attenuatesAngiostrongylus cantonensis-induced parasitic meningitis through modulation of HO-1 and NF-κB activation

In vitro efficacy of anthelmintics on Angiostrongylus cantonensis L3 larvae

The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis

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