Effects of AlCl3 on toad skin, human erythrocytes, and model cell membranes

Suwalsky, Mario; Ungerer, Brigitte; Villena, Fernando Pardo-Manuel de; Norris, Beryl; Cárdenas, Hernán; Zatta, Paolo

doi:10.1016/s0361-9230(01)00505-6

Cited by 24 publications

(8 citation statements)

References 26 publications

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“…[7][8][9][10][11][12] No biological function of the element has been identified, whereas some aspects of its toxicity have been described. 7,[13][14][15][16] Daily consumed dose of Al by food and beverages is 2.5 to 13 mg, where drinking water can contribute to 0.2 to 0.4 mg of Al daily. Drugs can contribute with increased levels of Al.…”

Section: General Informationmentioning

confidence: 99%

Genotoxic effects of aluminum, iron and manganese in human cells and experimental systems: A review of the literature

et al. 2011

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There is considerable evidence indicating an increase in neurodegenerative disorders in industrialized countries. The clinical symptoms and the possible mutagenic effects produced by acute poisoning and by chronic exposure to metals are of major interest. This study is a review of the data found concerning the genotoxic potential of three metals: aluminum (Al), iron (Fe) and manganese (Mn), with emphasis on their action on human cells.

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Section: General Informationmentioning

confidence: 99%

Genotoxic effects of aluminum, iron and manganese in human cells and experimental systems: A review of the literature

et al. 2011

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“…[9,10,11]. Aluminimum is known to affect the erythrocyte membrane integrity [20,21] and lowers haemoglobin levels interfering with haemoglobin synthesis. ), this high affinity to form Al(III)-phosphate compounds could disrupt key processes of the cell metabolism.…”

Section: Introductionmentioning

confidence: 99%

Aluminum interaction with 2,3-diphosphoglyceric acid. A computational study

et al. 2015

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The interaction of aluminum with 2,3-diphosphoglyceric acid (2,3-DPG) is thought to be one of the strongest interactions of aluminium with a biophosphate molecule. In this article, the affinity energies for a family of Al-(2,3-DPG) complexes are calculated at the DFT level of theory. The study includes a total of 26 structures that vary from 1:1 complexes, 1:2 stoichiometry and ternary complexes with citrate, considering different coordination modes and protonation states. Our results demonstrate that in the case of 1:1 complexes, 2,3-DPG ligand could compete with citrate for complexation with aluminum, at physiological pH. However, for the rest of the complexes there is a clear preference for Al(Citr)2 > Al(2,3-DPG)(Citr) ternary complex > Al(2,3-DPG)2 complexes. For each of these groups the charge of the ligand determines the affinity but at a lower extent that the nature of the Citr/2,3-DPG ligand. In summary, our results point to a high variety of possible complexation modes of 2,3-DPG to aluminum, showing higher preference towards the formation of ternary complexes.

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“…Aluminium (Al) is one of the most abundant elements in the biosphere and causes adverse effects on various organs (Suwalsky et al 2001;Reinke et al 2003). Human population is constantly exposed to Al through various sources such as Al cooking utensils, certain beverages and drinking water (Gupta et al 2005;Ochmanski and Barabasz 2000).…”

Section: Introductionmentioning

confidence: 99%

Potential of lithium to reduce aluminium-induced cytotoxic effects in rat brain

2009

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The present study was aimed to explore the potential of an antidepressant drug lithium (Li) in reducing aluminium (Al) induced neurotoxicity. To carry out the investigations, Al was administered orally (100 mg AlCl(3)/Kg b wt/day) whereas, Li was administered through diet (1.1 g Li(2)CO(3)/Kg diet, daily) for a total duration of 2 months. Al treatment resulted in a significant increase in the activity of enzyme nitric oxide synthase and the levels of L-citrulline which, however, were decreased appreciably following lithium supplementation. Al treatment also revealed an increase in DNA fragmentation as evidenced by an increase in number of comets. Interestingly, Li supplementation to Al treated rats reduced the damage inflicted on DNA by Al. Ultrastructural studies revealed an increase in chromatin condensation with discontinuity in nuclear membrane in both the cerebrum and cerebellum of Al treated rats which showed improvement following Li supplementation. Alterations in the structure of synapse and mitochondrial swelling were also seen. The present study shows the potential of Li in containing the damage inflicted by Al on rat brain.

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Effects of AlCl3 on toad skin, human erythrocytes, and model cell membranes

Cited by 24 publications

References 26 publications

Genotoxic effects of aluminum, iron and manganese in human cells and experimental systems: A review of the literature

Genotoxic effects of aluminum, iron and manganese in human cells and experimental systems: A review of the literature

Aluminum interaction with 2,3-diphosphoglyceric acid. A computational study

Potential of lithium to reduce aluminium-induced cytotoxic effects in rat brain

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