Effects of Alcohol and Cholesterol Feeding on Lipoprotein Metabolism and Cholesterol Absorption in Rabbits

Latour, M. A.; Patterson, Bruce W.; Kitchens, Robert Thomas; Ostlund, Richard E.; Hopkins, Daniel T.; Schonfeld, Gustav

doi:10.1161/01.atv.19.3.598

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…Already, the triglycerides levels were significant for the [GRF2] group, decreasing by 36% in relation to the control (p<0.05) and increasing levels in [ALC2] compared to [GRF2] (p<0.05). The increase in cholesterol levels at 13.98 mg.dL -1 in the [ALC1] group may reflect the increased absorption of dietary cholesterol or the induction of cholesterol absorption by alcohol (Latour et al, 1999). These findings were consistent with previous studies indicating that alcohol affected lipid metabolism (Toffolo et al, 2012) with increased cholesterol levels in rats treated with alcohol (Silva et al, 2015).…”

Section: Resultssupporting

confidence: 90%

Evaluation of the toxic effects of the bottled medicine (garrafada) containing the Echinacea purpurea, Annona muricata, Tabebuia avellanedae, Pterodon emarginatus and Uncaria tomentosa in rats

Indras¹,

Marek²,

Penteado³

et al. 2020

J. Med. Plants Res.

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This study evaluated if the oral administration of a bottled medicine containing Echinacea, Graviola, Purple Ipe, Sucupira and Cat's claw could cause changes in biochemical, coagulation, hematological and histopathological parameters in rats. This study arised after a report to Ceatox of a patient who used a bottled medicine and developed hematological, renal and histopathological changes. The bottled medicine possesses 4.32 mg alcohol.mL-1 and by the phytochemical screening and UV/Scan tests showed some classes of secondary metabolites. In experiments using Wistar rats, two treatments were performed, single dose and 30 days, administering water, alcohol and bottled medicine by gavage. In the single dose treatment, alterations of uric acid, cholesterol, creatinine, alkaline phosphatase, iron and glucose (p<0.05) were found. Already in the 30 days treatment were alterations of uric acid, total and indirect bilirubins, creatinine, alkaline phosphatase, glucose, triglycerides, erythrocytes and leukocytes (p<0.05), and hepatic sinusoidal dilatation. The data showed that the alcohol present in the bottled medicine can alter biochemical, hematological parameters and cause liver damage in rats. The bottled medicine, although not showing alterations in important biochemical and hematological parameters, had more pronounced liver histopathological alterations.

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Section: Resultssupporting

confidence: 90%

Evaluation of the toxic effects of the bottled medicine (garrafada) containing the Echinacea purpurea, Annona muricata, Tabebuia avellanedae, Pterodon emarginatus and Uncaria tomentosa in rats

Indras¹,

Marek²,

Penteado³

et al. 2020

J. Med. Plants Res.

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“…Component changes within lipoproteins (e.g., addition or depletion of CE or TG) may indicate poor assembly or removal [19]. As shown in the current study, VLDL particles were altered in terms of components, i.e., lower CE:PRO and TG:PRO ratios for ducklings originating from 24-week-old breeders.…”

Section: Discussionsupporting

confidence: 60%

The Circulating Levels of Lipoproteins in Embryos and Newly Hatched Ducklings Change with Parental Age<sup>1</sup>

2002

Self Cite

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The purpose of this study was to investigate the effects of duck breeder age on circulating very low density lipoprotein (VLDL) and low-density lipoprotein (LDL) levels in embryonic (day 25 of incubation) and newly hatched ducklings (hatch and 1, 2, 3, and 5 days after hatch). In this study, embryos and ducklings from one breeder flock were monitored at breeder ages 24 weeks (young breeders), 31 weeks (mature breeders and near peak egg production), and 47 weeks (after peak egg production). Embryos and newly hatched ducklings from young breeders (24 weeks of age) displayed lower levels of VLDL and LDL. The composition of VLDL was affected by breeder age such that embryos and ducklings from young breeders had less cholesterol ester/protein and triglyceride/protein ratios. Even though the overall levels were suppressed in embryos and newly hatched ducklings from 24-week-old breeders, the overall percentage of triglyceride within VLDL and LDL particles was higher. These data would suggest that breeder age affects concentration and composition of both VLDL and LDL in embryos and newly hatched ducklings.

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“…The increase of cholesterol levels by approximately 20 mg·dL −1 in the [EP10] and [Alc10] groups may reflect increased absorption of dietary cholesterol or altered protein metabolism. Some authors have reported a relationship between alcohol and both increased cholesterol levels and protein metabolism; this reflects channeling of peripheral amino acids to hepatic protein synthesis [ 25 ] and induction of cholesterol uptake [ 26 ] by alcohol. The mechanisms involved in the reduction of cholesterol levels by pterocarpans include acyl-CoA cholesterol acyltransferase (ACAT) inhibition.…”

Section: Discussionmentioning

confidence: 99%

Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function

Silva

Souza

Reichert

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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This study evaluated the influence of the alcohol present in a formulation of the antiophidic phytotherapic tincture, Específico-Pessôa, on rat blood biochemical and hematological parameters, and on organ histology. Three groups of rats were treated orally for 10, 15, or 30 days; one group received the tincture, the other received alcohol alone, and the third was a control group. The results of this study indicated that cholesterol levels were significantly increased after 10 days in the alcohol and tincture groups, although these decreased after 30 days in the tincture group. Triglyceride levels were significantly reduced after 15 days in the tincture group and after 30 days in the alcohol and tincture groups. A higher creatinine level was observed in the alcohol and tincture groups after 15 and 30 days. The uric acid levels in these groups were reduced at 10 and 30 days, although this metabolite was elevated at 15 days in the alcohol group. Hydropic multifocal degeneration with lymphohistiocytic infiltration and some polymorphonuclear cells was observed in the livers of rats treated with either the tincture or alcohol. These data demonstrate the importance of considering the potential actions of the alcohol present in pharmaceutical formulations.

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Effects of Alcohol and Cholesterol Feeding on Lipoprotein Metabolism and Cholesterol Absorption in Rabbits

Cited by 13 publications

References 19 publications

Evaluation of the toxic effects of the bottled medicine (garrafada) containing the Echinacea purpurea, Annona muricata, Tabebuia avellanedae, Pterodon emarginatus and Uncaria tomentosa in rats

Evaluation of the toxic effects of the bottled medicine (garrafada) containing the Echinacea purpurea, Annona muricata, Tabebuia avellanedae, Pterodon emarginatus and Uncaria tomentosa in rats

The Circulating Levels of Lipoproteins in Embryos and Newly Hatched Ducklings Change with Parental Age<sup>1</sup>

Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function

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